MakeChange

Make change.

[Al Haddrell @ukhadds]

When it comes to far-UVC, there are lots of knowns, some unknowns, and a lot of concerns that may not be warranted (and a few that might be). Like all things aerosol, it’s complicated. Hopefully the video will help you make sense of it.

[PsyPost.org @PsyPost]

A systematic review of 49 imaging studies highlights how COVID-19 affects the human brain. Researchers found widespread structural and functional changes in areas responsible for memory, emotion, and attention, providing insight into enduring… https://t.co/MfYUJiTq72

[tern @1goodtern]

It's curious watching people in denial about covid moan about people in denial about climate change.

[tern @1goodtern]

For the last four years I've been tracking the *unusual outbreaks* that have been happening since almost everyone chose to get repeatedly infected with Covid.

Covid infections make you more vulnerable to other infections.
It's simple science.
Here's the latest dramatic one:

[tern @1goodtern]

Covid infections don't *create* the other outbreaks.

But covid infections do weaken your body's systems that help you fight off a pathogen or a parasite, and also they weaken your body's systems that help prevent *spreading* a pathogen or parasite.

[Hiroshi Yasuda (保田浩志) @Yash25571056]

From a cohort study of 142 neonates born to women with SARS-CoV-2 infection in pregnancy,
"At one month, most infants had no medical concerns..
At 12 months, median ASQ and CSBS scores were above standardized cut-offs for development across all developmental domains..
At 22 months.., twenty-three (52%) infants presented with developmental impairment (score <85); 13 (30%) in motor, 17 (39%) in language, and 13 (30%) in cognitive domains.
Nine (20%) infants were below cut-off for all three domains..
[In conclusion,] Developmental delay at 22 months may be identified among infants with in utero exposure to SARS-CoV-2, despite typical developmental progress at 12 months..
Of those with developmental diversity, language delay was most common."

The target of Omicron is the next generation of human beings.

'The association of in utero SARS-CoV-2 exposure on neurodevelopmental outcomes at 12 and 22 months'
https://t.co/hJKDpfIBwp

[Harry Spoelstra @HarrySpoelstra]

Understanding neuroinflammation in post-COVID-19 syndrome: biological mechanisms, diagnostic biomarkers, and therapeutic prospects

🚨Long COVID is not “in your head,” it’s chronic brain inflammation that can outlive the virus itself!

➡️This now peer-reviewed expert review argues that chronic neuroinflammation is a central driver of post-COVID-19 syndrome (PCS)/LongC0vid,

➡️Sustained microglial and astrocyte activation, blood-brain barrier (BBB) disruption, and aberrant cytokine signalling (IL-6, TNF-α, IFN-γ) produce long-term brain dysfunction, explaining persistent cognitive, psychiatric, fatigue, and sleep symptoms,

➡️SARSCoV2 can reach the CNS via olfactory, neural, or haematogenous routes, infecting glia and neurons,

➡️Viral remnants persist in skull bone marrow and meninges, fuelling ongoing immune activation,

➡️Additional amplifiers include autoimmunity (molecular mimicry), reactivation of endogenous retroviruses (HERV-W/K) and latent viruses (EBV, HHV-6), neurovascular injury, impaired vagus-nerve anti-inflammatory signalling, and mast-cell histamine release,

➡️Diagnostic biomarkers converge: elevated fluid markers (GFAP, sTREM2, S100β) and neuroimaging signatures (increased TSPO-PET binding in limbic/frontal regions, elevated myo-inositol/choline on MRS, free-water increases on diffusion MRI, choroid-plexus enlargement),

➡️These point to low-grade glial reactivity and network instability,

➡️The authors propose a multiscale model in which neuroinflammation triggers local sleep intrusions, impairs memory reconsolidation, and destabilises fronto-limbic circuits, accounting for the fluctuating, heterogeneous nature of PCS.

➡️Targeted therapies (glial modulators, antihistamines, vagus-nerve stimulation, BBB stabilisers) are highlighted as possible promising avenues to follow,

➡️Review focuses exclusively on biological pathways after acute SARSCoV2 infection (glial activation, viral persistence in meninges/skull marrow, BBB disruption, autoimmunity, HERV reactivation, etc.) without addressing multiple infections or any vaccine-related factors,

‼️So, if I may summarise correctly, this post-COVID-19 syndrome phenotype is not residual fatigue or psychosomatic fog, it is chronic, self-sustaining neuroinflammation that continues to damage glial networks, breach the blood-brain barrier, and destabilise brain circuits long after the virus is gone. Without urgent, mitigation and mechanism-targeted interventions, this silent immune battle inside the brain will leave millions with permanent neurological injury.
#AvoidSars2 #AvoidReinfections #CleanAir #VaccinationUpdates
👏Thank you @DaniBeckman et al.
https://t.co/2ixjyAFsUz

[Mike Hoerger, PhD MSCR MBA @michael_hoerger]

New this week: The US federal government used keyword searches to target topics of research grants to defund.

COVlD was among the highest-priority banned topics.

(Link next)

[Mike Hoerger, PhD MSCR MBA @michael_hoerger]

Influenza is low across the board. COVlD is high in many places, and handwashing does nothing to prevent one from breathing virus deep into the lungs.

[MakeChange @2021MakeChange]

@michael_hoerger @CyFi10 Considering the population density in NY, it’s unacceptable that NY only has limited coverage per CDC.

[Mike Hoerger, PhD MSCR MBA @michael_hoerger]

NEJM: 1 in 38 patients in US hospitals are infected as a result of their medical care.

Most hospital-acquired infections are not from a specific device or procedure.

Perhaps, laissez faire masking policies are woefully inadequate? 😷

[Laura Miers @LauraMiers]

1994: “Cyclospora infection is common in Haitian patients with HIV infection, responds to trimethoprim-sulfamethoxazole therapy, and has a high recurrence rate that can be largely prevented with long-term trimethoprim-sulfamethoxazole prophylaxis.” https://t.co/IER9nDmRoc

[Mike Hoerger, PhD MSCR MBA @michael_hoerger]

PMC COVlD Update, Week of Jul 13, 2026 (US)

▪️1 in 250 Americans estimated actively infectious
▪️8 hot spots
▪️Texas and Guam outbreaks persist
▪️Florida outbreak worsens
▪️California Bay Area now with high levels

See Alt text for more detail.

THREAD 🧵1/3

[MakeChange @2021MakeChange]

@COVID19_disease Great news.
Now who’s going to develop it so ppl can get it?

[MakeChange @2021MakeChange]

@COVID19_disease @Threadreaderapp unroll

[Harry Spoelstra @HarrySpoelstra]

Implications of RNA virus persistence for post-acute sequelae and chronic inflammatory syndromes

🚨Textbooks are obsolete. I was right again!

The bad news SarsCoV2 brought for all those rooted ID/Virologists, their textbooks of acute RNA viruses is dead according to this new review!

➡️This new and very interesting review synthesizes evidence that many RNA viruses long considered strictly acute (SARSCoV2, influenza, RSV, measles, CHIKV, EBOV, etc.) can leave behind persistent viral products like replication-competent genomes, proteins, mutated forms, and non-standard viral genomes (nsVGs), even months to years after infectious virus is cleared.

➡️Study main findings:
- Persistence occurs in diverse reservoirs: tissue macrophages, dendritic cells, ILC2s, fibroblasts, neurons, and immune-privileged sites (brain, testes, joints, gut),

- Pathogen-Associated Molecular Patterns(PAMP’s) products continuously stimulate innate sensors driving chronic low-grade inflammation and tissue dysfunction,

- Documented links include longC0VID (SARSCoV2), subacute sclerosing panencephalitis (measles), persistent arthralgia (CHIKV), post-Ebola syndromes, and virus-driven asthma-like disease (Sendai virus model),

- nsVGs and immune-evasion tactics (IFN suppression, MHC downregulation, antigenic variation) help viruses or their remnants survive in host cells,

- Animal models show that removing specific persistently infected immune cells reduces chronic inflammation, proving a causal role,

➡️The review challenges the classical view that acute RNA virus infection reliably ends in complete clearance and durable protective immunity(= classic textbooks!),

➡️Reinfection impact is not directly addressed, the authors focus on post-acute/chronic sequelae rather than susceptibility to new infections.

‼️So, the comfortable assumption that acute RNA virus infections are self-limiting events followed by some kind of "sterilizing immunity" is outdated. Persistent viral products can instead establish a smouldering inflammatory state that drives debilitating chronic disease. For SARSCoV2 and similar viruses, this means the real long-term cost may not be (re)infection itself but the failure to ever fully resolve the first encounter, leaving behind reservoirs that keep the immune system chronically engaged and the host at risk of progressive organ damage. It just became a lot more complicated!
TEXTBOOKS OUT….#MITIGATION and #CLEANAIR IN!
https://t.co/lez6TzJ7iS

[Zdenek Vrozina @ZdenekVrozina]

The study in Clinical Ophthalmology - LISTEN, 595 people with long COVID.
57% report new ocular symptoms - blurred vision, dry eyes, floaters or flashes. The headline isn’t really about the eyes🧵

[Mike Hoerger, PhD MSCR MBA @michael_hoerger]

COVlD has been circulating at high/very high levels in Central/SE Texas. The Houston Chronicle has shared the PMC warning.

The situation in Houston is extremely uncertain and may be very bad -- will update soon.

(Link in next)

H/T @SHEMBR

[Al Haddrell @ukhadds]

Far-UVC is rapidly being recognised as an effective way to reduce the amount of infectious pathogens in indoor air

Given the importance of player's health when it comes to their performance, it's not surprising to see NFL teams utilising this new tech

https://t.co/ecf0UCLnPf

[Ivan l'Africain @AlterIvan1]

You'll see the same pattern in the news across EU countries, but so far only in Spain has anyone said it like it is 💀