Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟

Stay up-to-date in Infectious Diseases, Clinical Pharmacist, Antibiotics #IDXposts AKA #IDTwitter T🌟P influencer,@Wiki_Guidelines ,#Interstellar,#Dune,🌹❤️Misk

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🔥🔥Wow. Our article is published! @BradSpellberg 🎉🔥🔥

A journey that started with a simple question: What’s in a name?

Today, I’m incredibly grateful to see our article published in @CMIComms :

“What’s in a Name? The Rise of Klebsiella pneumoniae: From Friedländer to Klebs”

This is my first publication as first author, and having this journey with my mentor, co-author, and friend, Dr. Spellberg, makes this milestone even more special.

K. pneumoniae is an organism I deal with almost every day—often as a notorious MDR pathogen. Writing this article gave me the opportunity to step back from the daily clinical challenge and explore the fascinating story behind its name.

From Friedländer → Klebs → K.pneumoniae.

Alhamdulillah. 🤲🏻

EnJoy!

#IDXposts
https://t.co/uDB9UsL53S

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

@BradSpellberg @DrKullab10 Or chloramphenicol if you have
@DrToddLee

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Well, in the era of ceftaz avi and other BLBIs, I'm not sure whether Chloramphenicol has a role to play. Maybe folks in CA disagree! @DrToddLee @sebpoule
🆕️⚡️LTE Chloramphenicol activity against carbapenemase producing Enterobacterales #IDXposts
https://t.co/ZdFGCIytvA

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💥🟢External validation of the PACTO risk score for infective endocarditis in patients with coagulase-negative staphylococcal bacteremia: a multicenter cohort study #idxposts #IEWiki https://t.co/m9bJxnkQ6A

[Brad Spellberg @BradSpellberg]

@JulienPrvost5 @DiorIzzy @JulianVentres @ABsteward @DrToddLee I almost never discharge on IV. Almost all patients can be switched to oral. Every now and then you find a patient who doesn’t meet the five criteria for oral switch (eg, gut doesn’t work, resistant to all oral options, etc).

[Brad Spellberg @BradSpellberg]

@JulienPrvost5 @DiorIzzy @JulianVentres @ABsteward @DrToddLee The clock starts in 2019 with OVIVA/POET. So we're only 7 years in. 10 more years until the battleship has fully turned. Ive been doing oral for osteo and bacteremia since 2006. For endocarditis later. But, I do think 10 years is realistic. Until then, Just...Keep...Swimming.

[Brad Spellberg @BradSpellberg]

@JulianVentres @ABsteward @DrToddLee First, clunk their heads together like Mo to Curley and Shemp. Second, no IV lead-in for the Heldman S. aureus endocarditis RCT. Third, 12 RCTs of bacteremia show oral effective. Fourth, the bug doesn't know if you give the drug IV or po. Only that enough gets there to kill it.

[Anil Makam @AnilMakam]

SSC is a repeat offender of bad guidelines. we should collectively all just stop following them

but too bad CMS adopted SEP1. lousy process measures rebranded as "quality improvement" which is not supported by evidence. lactate is a really bad biomarker of perfusion. never been established that giving fluids to lower it helps. in fact it is worse when compared to a perfusion focused strategy

[Austin Akers, MD @apakers11]

@ABsteward Anecdotally it’s way more than one-third

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

CRAB causes severe respiratory infections with limited therapeutic options and high mortality. Although rifabutin exhibits potent activity against A. baumannii, oral administration results in low bioavailability and variable exposure. An intravenous formulation (BV100) was developed to overcome these limitations. #IDXposts

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

💥Very interesting!!👀
An exiting option for CRAB!
Intravenous rifabutin (BV100) achieves pulmonary exposures substantially exceeding plasma concentrations, providing a strong pharmacological rationale for further clinical evaluation of BV100 in severe CRAB pneumonia
💥First human data on lung penetration of IV rifabutin (BV100).
•Lung exposures exceed plasma 35-fold (ELF) and 311-fold (alveolar macrophages).
•Active metabolite25-O-deacetyl-rifabutin shows similar lung accumulation #idxposts
https://t.co/Qjv7K6Kpot

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

@BradSpellberg ICYMI

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

💥Very interesting!!👀
An exiting option for CRAB!
Intravenous rifabutin (BV100) achieves pulmonary exposures substantially exceeding plasma concentrations, providing a strong pharmacological rationale for further clinical evaluation of BV100 in severe CRAB pneumonia
💥First human data on lung penetration of IV rifabutin (BV100).
•Lung exposures exceed plasma 35-fold (ELF) and 311-fold (alveolar macrophages).
•Active metabolite25-O-deacetyl-rifabutin shows similar lung accumulation #idxposts
https://t.co/Qjv7K6Kpot

[Brad Spellberg @BradSpellberg]

@AnilMakam Petition to change clinical guideline process is coming soon! Everyone get ready to sign!

[Apu Akkad @ApuAkkad1]

Important to note this. “Bilateral lower extremity cellulitis” - very commonly said. Also Cellulitis not responding to antibiotics unlikely to be infectious unless other issues (ie peripheral vascular disease etc) .

[Johan Courjon MD PhD @johan_CNice]

@ABsteward Nice paper on this subject in 2018 with this RCT

https://t.co/Yoxuafl6xJ

[Todd C. Lee @DrToddLee]

@ABsteward A $35 off the shelf IR thermometer allowed differentiation of cellulitis from pseudocellutiits based on ID consultant as "gold standard"

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

@DrToddLee Thanks, can you please explain it briefly

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Misdiagnosis of cellulitis is common! Approximately one-third of hospitalized patients diagnosed with cellulitis may have a non-infectious diagnosis.
🆕💥🔴Mimics of Lower Extremity Cellulitis: An Approach to the Red Leg #idxposts
https://t.co/bwNTNhwtYw

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💥🟢 Development of a rapid diagnostic test for the cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus: Cefinase disk direct (CDD) test
The proposed CDD test demonstrated satisfactory diagnostic performance for the detection of blaZ type A-harboring MSSA isolates #idxposts
https://t.co/5WQJfGalsI

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕💥🔴Phase III clinical trial evaluated Silevimig, a bispecific anti-rabies monoclonal antibody targeting antigenic sites I and III, as a substitute for human rabies immunoglobulin (HRIG) in post-exposure prophylaxis. Silevimig is safe and effective alternative for passive rabies post-exposure prophylaxis #idxposts https://t.co/EeCvXGoJc6

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🔥🔥Back online🔥🔥
IDSA/ESCMID 2026 Guidelines on Staphylococcus aureus Bacteremia: Risk Stratification, Diagnostic Evaluation, and Management of Adults and Children Part-1
#IDXposts
https://t.co/X1kOKsrVfg