Chaoyu Fu

Postdoc at Mechanobiology Institute, NUS.

[BowTiedBiotech 🧪🔬🧬 @BowTiedBiotech]

Degrader Tac-opedia

🔘PROTAC: E3 ligase-targeted proteolysis
🔘DUBTAC: Deubiquitinase stabilization
🔘LYTAC: Lysosome-targeted degradation
🔘Trivalent PROTAC: Multivalent E3 ligase
🔘AUTAC: Autophagy-targeted degradation
🔘RIBOTAC: RNA-targeted degradation
🔘RNA-PROTAC: RNA-binding E3 ligase
🔘BioPROTAC: Antibody/peptide proteolysis
🔘Aptamer-PROTAC: Aptamer proteolysis
🔘GlueTAC: Lysosomal traffic & degradation
🔘Peptide-PROTAC: Peptide-based E3 ligase
🔘NanoTAC: Nanobody-based E3 ligase

H/T: Donggeon Kim on the HR app!

[Berna Sozen @BernaSozen_]

Our latest out today @Nature!
We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬
https://t.co/mfx6Hk7nma

[Chaoyu Fu @ChaoyuFu]

@Ella_Maru Thank you Ella. Yes, it can control tissue morphogenesis. That's one of the ongoing project in the lab.

[Chaoyu Fu @ChaoyuFu]

It's a long journey, and the effort has made this true. We discovered a homeostatic feedback loop between E-cadherin and EGFR that regulates intercellular viscosity during collective cell migration. | PNAS https://t.co/QpwIR15vWN

[Chaoyu Fu @ChaoyuFu]

It's a long journey, and the effort has made this true. We discovered a homeostatic feedback loop between E-cadherin and EGFR that regulates intercellular viscosity during collective cell migration. | PNAS https://t.co/QpwIR15vWN

[Chaoyu Fu @ChaoyuFu]

I would like to thank my two supervisors, Prof. Virgile Viasnoff (@Viasnofflab) and Prof. Michael Sheetz, for their invaluable guidance. It has been a great collaboration with Florian Dilasser and the team from JF Rupprecht's lab (@JFRupprecht_OM).

[bioRxiv Cell Biology @biorxiv_cellbio]

E-cadherin-dependent phosphorylation of EGFR governs a homeostatic feedback loop controlling intercellular junction viscosity and ... https://t.co/uxBo1EATeH #biorxiv_cellbio

[Chaoyu Fu @ChaoyuFu]

@feyzanar @nartimsoole @EdouardHannezo @HeisenbergCPLab @ISTAustria Congrats! Feyza!

[Chaoyu Fu @ChaoyuFu]

Really happy to share this work. EGFR has a ‘magic’ to change cortical actin dynamics without affecting cortical tension. Our further work also follows this point.

[MBI Young Scientists Group @MBI_YSG]

Congratulations to @AArora88 and Chaoyu on this preprint! Read it to find out more about their study on the cooperative regulation of adherens junction elongation between doublets through EGFR activation! 🔬#ScienceTwitter

https://t.co/LPYiWzxNAo