Hop in the Time Machine with me and let’s travel back 27 years to 1999, the last time the Knicks were in The Finals. I was 14 years old, and life was GOOD.
Eli Lilly released retatrutide Phase 3 data yesterday. 28% weight loss in 80 weeks. The most powerful obesity drug that’s ever been tested.
And today the cancer signal drops.
12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%). Breast cancer: 43% cut. Colon cancer five-year mortality in a separate study: 15.5% vs 37.1%.
Cancer joins a list that already includes heart disease (SELECT, 20% MACE reduction), kidney failure (FLOW, 24% slower decline), sleep apnea (SURMOUNT-OSA, FDA-approved), addiction (BMJ, 600K veterans, 18-25% reduction across substances), and liver disease (86% fat clearance).
Tumors express GLP-1 receptors. Activate them and NF-kB drops, apoptosis rises. The drug isn’t just shrinking fat. It’s talking directly to the cancer.
One drug class. Designed for blood sugar. The biology keeps finding uses the designers didn’t predict.
NEW: Youth sports is now costing parents as much as $25,000 a year.
Private equity and corporations are turning a childhood pastime into something only the wealthy can afford.
Youth sports has become a $40 billion industry, and the steep costs are crushing American families.
"Why three?" you ask. Great question by you. Because after you recite the first, people will go, "That's incredible, you've just casually memorized Shakespeare huh?" And then you'll go, "Oh no no, I can only recall a couple of his sonnets really." Then you recite the second. Then they'll say, "Wow, all I know is 'Shall I compare thee to a summer's day?'" And then you'll respond, "Haha yeah, that's a good one." Then you recite that full sonnet. After that, they'll assume you've committed to memory everything Shakespeare ever wrote and will forever speak your name in hushed and reverent tones.
Of course, for this to work, your third sonnet has to be Sonnet 18. That's crucial. I should've put that in the first tweet.
Anyway here are my three. Sonnet 29 for its beauty, Sonnet 130 to tease, and Sonnet 18 for the reasons explained above.
@quantian1 The Bosch dishwasher I have is so quiet I frequently open it mid-cycle without knowing it's on. GE fridge and stove have been pretty good, but I replaced the GE microwave with a whirlpool after the fuse blew 5 times, ymmv
NIXON: These goddamn… [garbled]… they call themselves incels. The hell does that even mean.
KISSINGER: I believe it stands for ‘involuntarily celebrate’, Mr. President
NIXON: Horrible. Shameful. That’s the worst thing i’ve ever heard. What does that make Bob?
HALDEMAN: [clearing throat] I’m a volcel…
KISSINGER: He’s a gooner, Mr. President.
NIXON: Don’t tell me what that is or I’ll slit your throat, Henry. If anyone here is a goddamn ‘gooner’ it’s you.
You can’t imagine how great it was to be a pizza delivery guy in 2005.
Entire families would celebrate your arrival like you were Santa Claus.
You’d have to navigate via map like a pirate.
Cops never messed with you. You’ve never seen a pizza delivery guy pulled over on the side of the road.
You got to carry around a wad of cash like a gangster.
Go back to the pizza shop and flirt with the waitresses. Chop it up with the cooks. Tease the new guy because he has a crush on a waitress (they later got married).
And they had just made a new classic rock radio station in NJ 105.7. So you could cycle between that, 104.3, and 92.3 and basically always have a banger on the radio.
Get off work and have more energy than when you went in.
Truly glorious.