Daisy Spark

Postdoctoral researcher @TheFlorey // Bridging preclinical and clinical development of drugs for neuropsychiatric disorders

[Daisy Spark @DaisyLSpark]

Very excited to see this review finally out – a look into the past, present, and future of schizophrenia drug discovery with a focus on improving preclinical to clinical translation. Thanks to ⁦@gdstewart82⁩ ⁦@chrislangmead⁩ ⁦@AFornito⁩ https://t.co/8deDt7WWv6

[Daisy Spark @DaisyLSpark]

Thanks to Michela Vermeulen, @roailim, @CJHatzipantelis, Patricia Rueda, Tara Sepehrizadeh, Michael De Veer, Clotilde Mannoury la Cour, @AFornito, @monica_langiu, @gdstewart82, @jess_nithi and @chrislangmead

[Daisy Spark @DaisyLSpark]

New paper from a collaborative effort in delineating the role of GPR88 in motivational behaviour (and the surprising absence of striatal dopamine dysfunction)
https://t.co/93NebDriCc

[Kate Merritt @drkatemerritt]

Are there glutamate subtypes in schizophrenia? (eg treatment resistant vs responders).
If so, we'd expect to see increased glutamate variability in patients compared to healthy volunteers.

This is what we looked at in this meta-analysis (1/)

https://t.co/x6LBHw55Ux

[Mark Zylka @MarkZylka]

Important study for neurosci field. Shows that the push to study males and female rodents (of a single strain) is misguided, and arguably leads entire fields to draw erroneous conclusions about sex differences. Sex differences in C57Bl/6 mice do not generalize to other strains.

[Daisy Spark @DaisyLSpark]

Rebranding as Dr Spark

[BryanRoth @zenbrainest]

" to accelerate development of targeted therapeutics ... regulatory agencies and the pharmaceutical industry must embrace ...trials focused on pathophysiologic pathways that impact specific symptom domains in subsets of patients, agnostic to diagnosis.'
https://t.co/cYj8OK5mD9

[Alex Fornito @AFornito]

Final version of @kristinasabr 's fab review on the role of cortico-striatal circuitry in psychosis, w/ J Tiego, now out in @BiologicalPsyc1:
https://t.co/kG4Fk2nwXT

[Jaan Aru @jaaanaru]

A game changer for neuroscience: MRI with millisecond precision.

Out now in @ScienceMagazine

https://t.co/ksUst1oxGa

[Valerio Zerbi @Valerio_Zerbi]

📢📢NEW PAPER from the lab! Combining #optogenetics and #fMRI is opening up new avenues for research into polysynaptic functional networks. Here we openly share our most detailed protocols and step-by-step instructions for doing opto-fMRI in rodents! https://t.co/eHj2qoiPEr

[Alessandro Gozzi @Gozzi_Ale]

Online today @BiologicalPsyc1 a perspective I co-authored with @Valerio_Zerbi 👏on the use of rodents to model & study brain dysconnectivity
➡️https://t.co/aAsHdjA5OL
This is part of upcoming special issue on biological mechanisms of human brain dysconnectivity (more soon!)

[BryanRoth @zenbrainest]

WOW!!
'Our data show that exposure to male versus female experimenters’ scents induces differential behavioral responses and alters responses to antidepressant-relevant doses of KET in mice.'
https://t.co/knXYgEP4eU

[Matthew Nour @Matt_Nour]

I'm pleased to share our Perspective on 'Functional Neuroimaging in Psychiatry', out today in
@NeuroCellPress, with @YunzheNeuro and Ray Dolan,
@MPC_CompPsych.

We reflect on progress and impasses over 3 decades' research.

https://t.co/ql2IjMXJhO

https://t.co/JsYKkF1D1Y

[Dr. Jill Becker @women_neurosci]

Female mice are less variable than male mice once again! https://t.co/nhbOidFIut

[Rob_McCutcheon @rob_mccutcheon]

New open access paper out in @molpsychiatry using PET-MR to investigate relationships between glutamate, dopamine, & cortical gray matter. With Antoine Rogeau, @sameerjauhar and @Matt_Nour.
https://t.co/S2nqdvJWjq 🧵1/n

[Daisy Spark @DaisyLSpark]

@KynaConn @gdstewart82 @chrislangmead @AFornito Thank you!!!

[Daisy Spark @DaisyLSpark]

Very excited to see this review finally out – a look into the past, present, and future of schizophrenia drug discovery with a focus on improving preclinical to clinical translation. Thanks to ⁦@gdstewart82⁩ ⁦@chrislangmead⁩ ⁦@AFornito⁩ https://t.co/8deDt7WWv6

[Daisy Spark @DaisyLSpark]

Proud to have spent my undergrad and postgrad at @MonashPharm (also hi mum & dad I'm famous) | Monash ranks number one in Pharmacy and Pharmacology - 2022 QS World Uni... https://t.co/JmztX68MhM via @YouTube

[Daisy Spark @DaisyLSpark]

@NilushiKarunar2 @gdstewart82 @chrislangmead @AFornito Thanks Nel! Of course – very fitting for their latest assignment

[Daisy Spark @DaisyLSpark]

@sim_scientist @gdstewart82 @chrislangmead @AFornito Thanks Sim!