Estonian Biobank

DNA samples and extensive health records of 20% of the adult population of Estonia (212,000 individuals), applied in 100s of international research projects.

[nature @Nature]

Research Briefing: An investigation of the Estonian Biobank and the UK Biobank has identified more than 88,000 associations between more than 8,000 genomic regions and metabolic traits.

https://t.co/BviVoEPDOt

[Lili Milani @MilaniLili]

✨ A new star allele was born! Excited to share our first in vivo pharmacokinetic recall study involving 114 participants from @ESTbiobank with previously uncharacterised variants in CYP2C19 and CYP2D6:
https://t.co/tmIhdnuuFA #Pharmacogenomics #PharmVar #ClinPGx

[Lili Milani @MilaniLili]

Mõnikord peetakse geenivaramut ekslikult tervishoiuasutuseks. Millist rolli täidab geenivaramu tegelikult Eesti tervishoiu innovatsioonis? https://t.co/EdSOVZAXPq

[Robin Hofmeister @Rbn_Hfmstr]

🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
🔗https://t.co/wnag6TiWWo

[genomicstartu @genomicstartu]

Great news! Our Associate Professor of Neuropsychiatric Genomics, Kelli Lehto, has been selected to receive the European Research Council grant!

💐Congrats on that outstanding achievement!

👉https://t.co/oVmN9UgXvn

[European Journal of Human Genetics @ejhg_journal]

A study of genetic effects on adverse events from antidepressants in the Estonian Biobank: CYP2C19 and polygenic risk scores.
@ESTbiobank @MilaniLili @HannaKariis

https://t.co/L2yawUEZPO

[Robin Hofmeister @Rbn_Hfmstr]

🚨 Our parent-of-origin study is out in @Nature ! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗https://t.co/OWW6vGxGYI

Highlights below!

[Hanna Maria Kariis @HannaKariis]

🎉 Excited to share that our latest paper is now published!

We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @ESTbiobank, leveraging data from questionnaires and clinical notes using NLP.
https://t.co/Easbg4XDet

[Nature Portfolio @NaturePortfolio]

A study in @NatureMedicine provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses. https://t.co/Kd3Fu1fYXd 🔒

[Lili Milani @MilaniLili]

Excited to share our recently published overview of the @ESTbiobank 🧬
We highlight the unique features of the biobank and the conducted scientific research, including the many recall studies that have been carried out over the years:
https://t.co/q7k7f2CuS8

[Lili Milani @MilaniLili]

💡Can we use real world drug purchase data to study the genetics of medication dosing?

We explored this by analyzing 20 years of digital drug dispensing data linked to the @ESTbiobank which hosts 212,000 genotyped participants. 🧵

📄 https://t.co/4AfF6KxwAw

[Estonian Biobank @ESTbiobank]

Tremendous work by @PujolGualdo @TLaisk and team! 👏🏼👏🏼👏🏼

[Nature Medicine @NatureMedicine]

A new study provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses. @genomicstartu #ReproductiveHealth
https://t.co/JoenfG1rim

[Tartu_Microbiome @TartuMicrobiome]

New paper out: microbiome and causal inference! Let us tell you a bit more:

[TIMESPAN @TIMESPAN_H2020]

🧬🧠Recent research @ESTbiobank @genomicstartu revealed that high genetic liability to #ADHD raises risks for 80 health conditions like #COPD (+70%), #obesity (+60%) & type 2 diabetes #T2D (+45%) - even without an ADHD diagnosis. Better screening & awareness for adults is needed!

[PGC Consortium @PGCgenetics]

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @CellCellPress.

https://t.co/5ZtpbzKLpx

A thread 🧵:

[Abdulla Khaleel @abkhaleel]

Delighted to accompany President Dr. @MMuizzu on his visit to the @unitartu Institute of Molecular and Cell Biology, today.

We were warmly welcomed by Professor @MilaniLili, Head of Estonian Biobank & Professor of Pharmacogenomics and had an inspiring exchange on advancing digital health and genetic research.

@ESTbiobank @genomicstartu

[Kelli Lehto @lehto_kelli]

We are delighted to contribute with Estonian Biobank data to this massive collaboration 🎉 So glad to see this work published!

[Lili Milani @MilaniLili]

This is what happens when you return research results to biobank participants:
✅The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?”
✅"Estonian Biobank" among Top10 search terms.
Huge thanks to all at @ESTbiobank & @genomicstartu ✨

[Kateryna Pantiukh 🇺🇦 @KPantiukh]

🦠 Excited to share our new collection of human gut #archaea species! 🎉
🇪🇪From @ESTbiobank, we present a dataset of 144 strains across 21 species, including 9 entirely new species!
A thread 🧵
#MAG #EstMB #TartuMicrobiome #microbiome #humangut

[Neil Ward @GenomicsUK]

In @Laboratorynews, I discuss the role of biobanks in revolutionising precision medicine. 🧬

I explain how the @ESTbiobank is using genomic insights to better understand the factors influencing public health and disease.

Read more, here 👉https://t.co/Ct24EkYsLI

#Biobanks