DNA samples and extensive health records of 20% of the adult population of Estonia (212,000 individuals), applied in 100s of international research projects.
Research Briefing: An investigation of the Estonian Biobank and the UK Biobank has identified more than 88,000 associations between more than 8,000 genomic regions and metabolic traits.
https://t.co/BviVoEPDOt
✨ A new star allele was born! Excited to share our first in vivo pharmacokinetic recall study involving 114 participants from @ESTbiobank with previously uncharacterised variants in CYP2C19 and CYP2D6:
https://t.co/tmIhdnuuFA #Pharmacogenomics#PharmVar#ClinPGx
Mõnikord peetakse geenivaramut ekslikult tervishoiuasutuseks. Millist rolli täidab geenivaramu tegelikult Eesti tervishoiu innovatsioonis? https://t.co/EdSOVZAXPq
🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
🔗https://t.co/wnag6TiWWo
Great news! Our Associate Professor of Neuropsychiatric Genomics, Kelli Lehto, has been selected to receive the European Research Council grant!
💐Congrats on that outstanding achievement!
👉https://t.co/oVmN9UgXvn
A study of genetic effects on adverse events from antidepressants in the Estonian Biobank: CYP2C19 and polygenic risk scores.
@ESTbiobank@MilaniLili@HannaKariis
https://t.co/L2yawUEZPO
🚨 Our parent-of-origin study is out in @Nature ! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗https://t.co/OWW6vGxGYI
Highlights below!
🎉 Excited to share that our latest paper is now published!
We investigated genetic factors linked to antidepressant side effects in 13,000 individuals from the @ESTbiobank, leveraging data from questionnaires and clinical notes using NLP.
https://t.co/Easbg4XDet
A study in @NatureMedicine provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses. https://t.co/Kd3Fu1fYXd 🔒
Excited to share our recently published overview of the @ESTbiobank 🧬
We highlight the unique features of the biobank and the conducted scientific research, including the many recall studies that have been carried out over the years:
https://t.co/q7k7f2CuS8
💡Can we use real world drug purchase data to study the genetics of medication dosing?
We explored this by analyzing 20 years of digital drug dispensing data linked to the @ESTbiobank which hosts 212,000 genotyped participants. 🧵
📄 https://t.co/4AfF6KxwAw
A new study provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses. @genomicstartu#ReproductiveHealth
https://t.co/JoenfG1rim
🧬🧠Recent research @ESTbiobank@genomicstartu revealed that high genetic liability to #ADHD raises risks for 80 health conditions like #COPD (+70%), #obesity (+60%) & type 2 diabetes #T2D (+45%) - even without an ADHD diagnosis. Better screening & awareness for adults is needed!
Delighted to accompany President Dr. @MMuizzu on his visit to the @unitartu Institute of Molecular and Cell Biology, today.
We were warmly welcomed by Professor @MilaniLili, Head of Estonian Biobank & Professor of Pharmacogenomics and had an inspiring exchange on advancing digital health and genetic research.
@ESTbiobank@genomicstartu
This is what happens when you return research results to biobank participants:
✅The 2nd most googled “How to…?” question in Estonia 2024: “How to become a biobank participant?”
✅"Estonian Biobank" among Top10 search terms.
Huge thanks to all at @ESTbiobank & @genomicstartu ✨
In @Laboratorynews, I discuss the role of biobanks in revolutionising precision medicine. 🧬
I explain how the @ESTbiobank is using genomic insights to better understand the factors influencing public health and disease.
Read more, here 👉https://t.co/Ct24EkYsLI
#Biobanks