George Liperis

Consultant Embryologist | Senior Lecturer University of Sydney | ESHRE certified Senior Embryologist | Views my own

[Dr. Georges Raad @Dr_Georges_Raad]

@SCobanMune @OmarRawi89 @GLiperis @Repro_Fertility @zaliheyarkiner @berilyuksel @marcos

[George Liperis @GLiperis]

https://t.co/YvqnGLJLzy

@OmarRawi89 @juanjo_fraire @NoemiSalme30386 @AttilioDGM7 @DKalaitzopoulos @Saara_riibeiro @MairaCasalechi Julie LABROSSE
#ESHRE

[George Liperis @GLiperis]

🎉 Scientific Speed Dating returns at #ESHRE2026 in London!

👩🏼‍🔬 Junior professionals don’t miss this chance to connect with leading experts.

💡 Exchange ideas, spark collaborations&discover opportunities.

👥 Secure your spot !

Co-organised by the #ESHREjc&young talent group

[George Liperis @GLiperis]

🌟 Conclusion
The oocyte cortex is a biomechanical decision-making layer controlling fertility, genome stability, and embryo survival and a powerful future tool for non-invasive IVF diagnostics. #ESHREjc

[George Liperis @GLiperis]

🧬 The Oocyte Cortex: Fertility’s Hidden Control Layer

To find out join #ESHREjc on Friday 29th of January starting at 17:00 CET.
@paolavigano @rvassena Enrica Bianchi and authors Giovanni Cotichio and Danilo Cimadomo

Paper ➡️ https://t.co/HEoVua7jhs

🧵 #bluetorial 👇🏻

[George Liperis @GLiperis]

💉 ICSI = A Cortical Stress Test
Injection funnel shape & persistence reflect cortical health and predict fragmentation, blastocyst quality, and pregnancy outcomes. #ESHREjc

[George Liperis @GLiperis]

📊 IVF Insight

Mechanical tests show:
Cortical stiffness predicts blastulation better than morphology alone.

Biomechanics > embryologist grading
#ESHREjc

[George Liperis @GLiperis]

🎯 Cortex Stiffness Tunes Chromosome Fidelity
Too stiff?
Too soft?
→ Both cause spindle failure and aneuploidy.
There is a narrow “Goldilocks zone.” #ESHREjc

[George Liperis @GLiperis]

⚡ Fyn Kinase = Cortical Master Regulator
Loss of Fyn → defective actin cortex, failed polar body extrusion, abnormal zona pellucida, chromosome errors → subfertility. #ESHREjc

[George Liperis @GLiperis]

🧱 Actomyosin Engineers the Cortex

ERM proteins+actin+myosin sculpt polarity, actin caps, and spindle migration.

Disruption = misalignment, meiotic arrest, aneuploidy.

#ESHREjc

[George Liperis @GLiperis]

⚖️ Mechanical Polarity
• Low-tension microvillar domain → sperm fusion
• High-tension amicrovillar domain → spindle anchoring
A 2.5× tension difference controls asymmetric division. #ESHREjc

[George Liperis @GLiperis]

🌀 Meiosis Triggers Cortical Remodelling
TZPs retract → cortex reorganises → asymmetric forces reposition the spindle → polar body extrusion becomes possible.
Bad cortex = poor embryos. #EHSREjc

[George Liperis @GLiperis]

🔁 Bi-directional Signalling
Through the cortex:
• CC → oocyte: metabolites, meiotic arrest
• Oocyte → CC: BMP15, GDF9
→ Oocyte competence depends on cortical signalling. #ESHREjc

[George Liperis @GLiperis]

🦄 Oocytes Are Different
Typical cell cortex: 50–400nm
Oocyte cortex: ++ Thick
➡️ Thickness: Specialised functions.

🤝 Cortex: Communication Hub
Hosts transzonal projections (TZPs): actin bridges that connect cumulus cells&oocyte, delivering nutrients and signals. #ESHREjc

[George Liperis @GLiperis]

🧶 The oocyte cortex is not just a membrane lining. It’s a specialised micromechanical command centre that controls meiosis, fertilisation, embryo integrity, and IVF success. #ESHREjc

[George Liperis @GLiperis]

🚨 Is the oocyte cortex the hidden key to egg quality, fertilisation, and embryo development?

Join us for the next #ESHREjc
🗓 30–31 January
⏰ 17:00 CET start
📍 on @ESHRE

https://t.co/XRzhcI0492

Experts 👉🏻 @RitaVassena @PaolaVigano3

[George Liperis @GLiperis]

The new channel for science dissemination. Dont miss our #ESHREjc discussions also being hosted on bluesky 🦋 from ➡️ January 2026

[ESHRE @ESHRE]

Hello Bluesky friends! 💙🦋
We’re settling in nicely and enjoying every new connection.
If you haven’t said hi yet, drop by @eshre.bsky.social - our door is always open.
#ESHRE #WeAreOnBluesky #ReproductiveHealth #FertilityScience #NewToBlueSky #MedicalResearch #Infertility

[Kalaitzopoulos Dimitrios Rafail @DKalaitzopoulos]

@GLiperis @ESHRE @OmarRawi89 @juanjo_fraire @NoemiSalme30386 @juliauraji @AttilioDGM7 @FabrizzioHorta I totally agree with you @GLiperis. The problem is that the alternatives do not appear to be less harmful than paracetamol. I think the main rule for paracetamole should be "use the lowest effective dose in the shorter time" and for sure not prophylactic #ESHREjc

[Kalaitzopoulos Dimitrios Rafail @DKalaitzopoulos]

@juanjo_fraire @catiamalinina @Kristensen8511 @OmarRawi89 @ESHRE @juliauraji @AttilioDGM7 @GLiperis @Saara_riibeiro @NoemiSalme30386 I believe that, from a design perspective, it should not be difficult to conduct a retrospective clinical study examining the effect of paracetamol exposure during ovarian stimulation or embryo transfer, in order to obtain clinical evidence.

[George Liperis @GLiperis]

@catiamalinina @juanjo_fraire @OmarRawi89 @DKalaitzopoulos @ESHRE @NoemiSalme30386 @juliauraji @AttilioDGM7 @FabrizzioHorta 💯