Ion Channels @Leeds

Ion channel research at the University of Leeds.
Tweeting our publications and updates from our laboratories.

[Ion Channel Library @ionchannellib]

Upcoming Webinar - Tuesday 29th June at 14.00 BST

@DrJonLippiat will talk about the discovery of KNa1.1 (KCNT1, SLACK, Slo2.2) channel inhibitors using virtual screening and CryoEM structures.

If interested, register here: https://t.co/by9bJEMpn3

#ionchannels @Metrion_Biosci

[Jon Lippiat @DrJonLippiat]

Any channel-lovers looking for a job? We have a postdoc position available on a project to characterise our next set of novel KCNT1 potassium channel inhibitors. Deadline 28 April. #KCNT1 #ionchannels #epilepsy https://t.co/QKm6zJdA85

[Pliotas Group @PliotasGroup]

In our new RSC review we accumulated DEER/PELDOR studies of membrane proteins over 15 years ABC/Multidrug/Secondary transporters, to GPCRs, SEC transloc, Photosynth. & Mitochondr, OMPs, ion channels et al, combined with multiple lipid mimics and MD tools : https://t.co/0QisgCl6gd

[Robin Bon @RSBon_Lab]

Proud that our work on understanding small-molecule modulation of #TRPC channels by #CryoEM has now been published in @CommsBio. Great work driven by @scidave with @chmkjs @RachelJ9908 @profdbeech @stemuench from @UoL_LICAMM @AstburyCentre @Astbury_BSL. https://t.co/3rg1NweGyg

[Ion Channels @Leeds @IonChannelLeeds]

Another collaboration between Leeds ion channel and virology groups.

[Jon Lippiat @DrJonLippiat]

New publication: TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection https://t.co/E09n6ilUjP #ionchannels

[Jian Shi @JianShi_Leeds]

Delighted to share our latest work published today in @CellReports on how intrinsically rapidly-inactivated PIEZO1 channels sense sustained mechanical force such as blood flow in endothelium. Thanks to our team in @unileedscardio and Toulouse. https://t.co/W3gxWNxYI0

[👋[email protected]👋 @RichardBJ1]

Patch-clamp: Long shot; anyone know a patcher in the Liverpool area up for some short term/part time single-channel WORK on a great but easy project!? Even PhD student as part-time casual OK if can patch!! #ionchannels
@Channelomics
@RainbowLabUoL
@ClaireMemimo
@david_colquhoun

[Pliotas Group @PliotasGroup]

@Bela_Bode @mayue3691 @LeedsIMB @IonChannelLeeds @AstburyCentre @ScienceLeeds @EPR_ESR @Channelomics

[Sam Dobson @samjdobson]

Please to announce my first first author paper is out now in Antiviral Research! Looking at the role of ion channels during the entry of the polyomaviruses SV40 and MCPyV

https://t.co/Ro8KXWJzLX

[Ion Channels @Leeds @IonChannelLeeds]

Local Ca2+ signals couple activation of TRPV1 and ANO1 sensory ion channels https://t.co/KplicZmD7O

[Jon Lippiat @DrJonLippiat]

It's published! #ionchannels #kcnt1 #epilepsy @Beth_aimee_cole @RachelJ9908 @jeff_dddd @FishwickGroup @stemuench

[Jian Shi @JianShi_Leeds]

I am delighted to join the editorial board of The Journal of Physiology (the most prestigious and leading journal on physiology since 1878) as an editorial board fellow. Look forward to working with you @JPhysiol to serve the whole community.

[Robin Bon @RSBon_Lab]

Very proud to share the first #CryoEM studies by our @UoL_LICAMM @AstburyCentre #TRPC team: Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site. https://t.co/gzbiuDU6P3

[Ion Channels @Leeds @IonChannelLeeds]

We're delighted that @RohacsTibor is visiting us today. He will be delivering his seminar on "Regulation of TRPM Channels by G-proteins and phosphoinositides" at 2pm in RSLT23.

[Ion Channels @Leeds @IonChannelLeeds]

New #ionchannels publication from Leeds researchers @PliotasGroup and @DrJonLippiat featuring PELDOR/DEER spectroscopy and patch clamp of reconstituted mechanosensitive channels.

[Pliotas Group @PliotasGroup]

Pleased to see our study in @NatureComms. We show the high threshold mechanosensitive channel could be allosterically modulated
https://t.co/4Ywm3cpr84

@AstburyCentre @LeedsIMB @IonChannelLeeds @Bela_Bode @DrJonLippiat @StAndrewsBSRC @ScienceLeeds @SchoolofBiology @news_RSE

[Ion Channels @Leeds @IonChannelLeeds]

New research posted as a #preprint from our Ion Channel and Membrane Protein structural biology teams @LeedsIMB

[Jon Lippiat @DrJonLippiat]

First #preprint alert. Are cryo-EM structures any good in virtual HTS for ion channel modulators? #KCNT1 #ionchannels #epilepsy @beth_aimee_cole @RachelJ9908 @stemuench @jeff_dddd @FishwickGroup @AutifonyLtd

https://t.co/1chJpoGhvr

[Ion Channels @Leeds @IonChannelLeeds]

#PLOSCompBio: Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entra ... https://t.co/bDEPi5cPrj

[Ion Channels @Leeds @IonChannelLeeds]

#PLOSNTDs: Chikungunya virus requires cellular chloride channels for efficient genome replication https://t.co/trniOJECQ3

[Ion Channels @Leeds @IonChannelLeeds]

A Mechanism for Statin-Induced Susceptibility to Myopathy https://t.co/bW55QeWXl4

[Ion Channels @Leeds @IonChannelLeeds]

A cytoplasmic Slo3 isoform is expressed in somatic tissues @drjonlippiat https://t.co/2LAWfQBJvF