Adrian Isaacs

Investigating frontotemporal dementia and motor neuron disease at the UK Dementia Research Institute and UCL Queen Square Institute of Neurology

[Adrian Isaacs @isaacs_adrian]

A day in the life of our superstar tech Yash! recorded for @DHSCgovuk
https://t.co/rjwtfRkPjL
@UKDRI @UCLBrainScience @in2scienceUK

[Adrian Isaacs @isaacs_adrian]

Our open access opinion in @Brain1878 on the disappointing C9 ASO trials and next steps to deliver an effective treatment for C9ALS/FTD co-written with @AlexCammack @RubikaBalendra @UKDRI @UCLIoN https://t.co/A4kgL7j5bA

[UK Dementia Research Institute @UKDRI]

A study led by @isaacs_adrian (UK DRI at @UCLIoN) reveals a protective response in cells to early changes in ALS & FTD🧠

The research provides important insight that could lead to new therapeutic avenues to treat FTD & ALS👉https://t.co/hX5WoXQ2Bo

[Alzforum @alzforum]

New knock-in #ALS/#FTD mice express less normal C9ORF72 along with repeat dipeptides. They feature a protective collagen response. @UCL https://t.co/L4PiKuyI4b

[Adrian Isaacs @isaacs_adrian]

Delighted to see our study led by @milioto_carmelo revealing a neuroprotective ECM signature in C9FTD/ALS published! Thanks to @mndassoc @UKDRI and many others! https://t.co/WOMA0Q2KLd

[Adrian Isaacs @isaacs_adrian]

Brilliant to see former lab member Emma Clayton blazing her own trail!

[UK Dementia Research Institute @UKDRI]

Happy @WomenScienceDay!!🥳 🎉 🙌

Don't miss our new feature with UK DRI Emerging Leader Dr Emma Clayton. In the piece, Dr Clayton discusses her career path, the importance of representation and her passion for public engagement👏 👉https://t.co/XlHap2qoLs

#WomenInScience

[Adrian Isaacs @isaacs_adrian]

We have a new @lifearc1 funded post-doc position to follow up this work, applications close Feb 6th:
https://t.co/aDNgGHgvbr

[Adrian Isaacs @isaacs_adrian]

After failure of ASO trials targeting C9orf72 sense repeats also targeting antisense repeats is now vital. Our new preprint shows a potential approach using CRISPR-CasRx @UKDRI @UCLIoN @AlexCammack https://t.co/Sosm0dO9Po

[Adrian Isaacs @isaacs_adrian]

After failure of ASO trials targeting C9orf72 sense repeats also targeting antisense repeats is now vital. Our new preprint shows a potential approach using CRISPR-CasRx @UKDRI @UCLIoN @AlexCammack https://t.co/Sosm0dO9Po

[Adrian Isaacs @isaacs_adrian]

Taken together this suggests that getting PUFAs to neurons is important for their beneficial effect. Interventions that can boost neuronal lipid desaturation could therefore provide benefit in FTD/ALS 9/9

[Adrian Isaacs @isaacs_adrian]

Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by @AshlingGiblin and @AlexCammack https://t.co/NIm2FmGZV5 1/9

[Adrian Isaacs @isaacs_adrian]

Feeding C9 flies PUFAs was beneficial but neuronally over-expressing fatty acid desaturase enzymes was much more effective, and the same fatty acid desaturase also reduced stressor-induced toxicity in C9 iPSC-neurons 8/9

[Alzheimer's Research UK @AlzResearchUK]

.@isaacs_adrian shares his optimism for new dementia treatments.

He & his team of researchers @UKDRI are studying the underlying causes of dementia that will one day lead to new treatments for people with diseases like Alzheimer’s.

His vital work will help us change the ending.

[UCL Queen Square Motor Neuron Disease Centre @UCLQSMNDCentre]

We are pleased to announce that the Fourth UCL Queen Square Motor Neuron Disease Centre International Symposium (hybrid event) will take place on Friday 8th September 2023.

To register for this exciting meeting - https://t.co/0TCKxAFtYm

[Adrian Isaacs @isaacs_adrian]

Excited to be presenting unpublished work at the Lipids in Brain Diseases Symposium @LipidsInBrain in September. Hoping to learn a lot and still time to register: https://t.co/0gP5yuHfrT