JAMA Neurology

JAMA Neurology is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.

[JAMA Neurology @JAMANeuro]

In 2 clinical trials, once-daily #tevapadon improved symptoms in patients with #ParkinsonDisease, increasing daily good on time in those taking levodopa and improving motor scores in early disease vs placebo.

📖 Read the full article to learn more: https://t.co/cQzOihIPBD

[JAMA Neurology @JAMANeuro]

Female sex, smoking, and family history were independent risk factors for de novo #IntracranialAneurysm formation after #AneurysmalSubarachnoidHemorrhage, and #SmokingCessation was associated with lower risk.

https://t.co/sCyRGgOmxa

[JAMA Neurology @JAMANeuro]

💬 Editorial: A shared #TDP43 disease framework could improve cross-specialty research, but heterogeneity in pathology, phenotype, and coexisting proteinopathies may limit how broadly it can be applied. https://t.co/TR6yoR5ygt

[JAMA Neurology @JAMANeuro]

This JAMA Neurology #Review proposes #TDP43-associated #neurodegenerative disease as a staging framework that links presymptomatic biology with later clinical phenotypes and could support earlier mechanism-based treatment development.

https://t.co/Aw6XXHzPtN

[JAMA Neurology @JAMANeuro]

Performance of the FDA-cleared Lumipulse plasma #biomarker for amyloid pathology detection in #AlzheimerDisease varied by site and reagent lots, highlighting need for local assay verification and ongoing quality control. https://t.co/7wNTRhICR1

[JAMA Neurology @JAMANeuro]

Quantile aggregation may artificially inflate amyloid-cognition associations in #AlzheimerDisease trials, highlighting need for causally interpretable methods when assessing surrogate endpoints. https://t.co/NF8glwRPup

[JAMA Neurology @JAMANeuro]

Delayed onset of hemichorea and dystonia can occur after cortical temporal #Stroke, even when imaging reveals small acute ischemic lesions and routine blood tests are normal. https://t.co/S1T9ce3kox

[JAMA Neurology @JAMANeuro]

#CavernousSinus dural arteriovenous fistula can present with proptosis, conjunctival injection, and ophthalmoplegia; endovascular embolization achieved complete occlusion and rapid symptom resolution in this case. https://t.co/zxUXY3mVVX

[JAMA Neurology @JAMANeuro]

📑 JAMA Neurology #Review: Gene delivery platforms for #Glioblastoma include viral vectors, lipid nanoparticles, and nanocarriers, with oncolytic HSV gaining approval and new nonviral approaches entering early clinical trials in #NeuroOncology. https://t.co/VjHIrKa57s

[JAMA Neurology @JAMANeuro]

Integrating genetic and pathological data increased diagnostic accuracy and identified ancestry-related differences in #ParkinsonDisease, supporting biologically informed diagnostic tools and future pathology-targeted therapeutic trials. https://t.co/Qfy5ah3PYK

[JAMA Neurology @JAMANeuro]

💬 Viewpoint: For inflight #Epilepsy emergencies, nasal and buccal benzodiazepines may provide practical rescue options, supporting updated airline medical kit requirements and standardized crew training. https://t.co/aGRcNndgx1

[JAMA Neurology @JAMANeuro]

A reperfusion-guided systolic blood pressure strategy improved functional outcomes and reduced hemorrhagic transformation for patients with acute #Stroke after endovascular therapy compared with guideline-recommended management. https://t.co/t6jh4ezXBQ

[JAMA Neurology @JAMANeuro]

Among patients with idiopathic #Myelopathy, screening for anti-CD320 antibodies with metabolic confirmation of central nervous system–restricted #VitaminB12 deficiency may help clarify diagnosis and guide treatment evaluation.

https://t.co/i3yV726oJa

[JAMA Neurology @JAMANeuro]

Among adults with #Epilepsy receiving direct oral anticoagulants, antiseizure medication selection was associated with different risks of thromboembolic events, major bleeding, and all-cause mortality.

https://t.co/IyCiV9DvrK

[JAMA Neurology @JAMANeuro]

Among patients with familial or sporadic #FrontotemporalDementia, cerebrospinal fluid TMEM106B levels were lower with greater disease severity, progression, smaller brain volumes, and in carriers of the protective rs1990622 genotype. https://t.co/IT97T25btS

[JAMA Neurology @JAMANeuro]

Among patients with acute ischemic stroke due to large-vessel occlusion, standard-dose tenecteplase resulted in greater early reperfusion vs low-dose alteplase, with comparable functional and safety outcomes. https://t.co/8z0MlyRMPI

[JAMA Neurology @JAMANeuro]

Among veterans with prior #TraumaticBrainInjury, the plasma p-tau217/Aβ42 blood test for #AlzheimerDisease missed over half of brain amyloid-positive cases, indicating reduced diagnostic accuracy in this population. https://t.co/2Syotw5ja9

[JAMA Neurology @JAMANeuro]

Randomized clinical trial indicates middle meningeal artery embolization with n-butyl cyanoacrylate plus standard care reduced #SubduralHematoma recurrence and need for surgery vs standard care alone, with comparable safety profile. https://t.co/dkr7ZN65in

[JAMA Neurology @JAMANeuro]

Among adult #Ebola survivors, neurological symptoms such as memory loss, headaches, and depression remained common even 7 years post-infection, although most improved over time.

https://t.co/dmbTI4Y548

[JAMA Neurology @JAMANeuro]

A patient with isolated peripheral nerve vasculitis developed reversible bilateral hypoglossal palsy and tongue atrophy, with resolution of bulbar symptoms following immunosuppressive therapy and reinnervation, a rare neurological outcome.

https://t.co/fqd2FuKw0s