The Journal of Immunology

The Journal of Immunology is an official journal of The American Association of Immunologists, Inc., @ImmunologyAAI.

[The Journal of Immunology @J_Immunol]

Data show Hup as a conserved CD4 T cell antigen target across bacterial species and that T cell polarization and pathogen lifecycle are critical considerations when designing pan-antibacterial vaccines targeting shared bacterial antigens. Learn more: https://t.co/3CQcFmKpfy.

[The Journal of Immunology @J_Immunol]

Data show that the GLT2 inhibitor dapagliflozin improves organ damage and inflammation in sepsis with diabetes by promoting macrophage M2 polarization through inhibition of the APOC1/HMGB1/TLR4 axis. Read more: https://t.co/vMgnRI9NbX.

[The Journal of Immunology @J_Immunol]

Researchers found that Qβ bacteriophage nanoparticles functioned as an adjuvant capable of eliciting long-term memory. These data support the use of bacteriophage-derived nanoparticles for conjugate vaccines against antibiotic-resistant bacteria.

🔗 https://t.co/aUJROVSpQ0

[The Journal of Immunology @J_Immunol]

Data identifies circNav1 as a conserved circRNA of murine macrophages that fine-tunes inflammatory gene expression by coupling HuR-dependent Cebpb mRNA stabilization to selective IL-6 transcription. Learn more: https://t.co/BP258vBdE9.

[The Journal of Immunology @J_Immunol]

New data show that IFN-α subtypes can stimulate unique responses and distinctly modulate both CD4 and CD8 T cells contributing to the growing body of evidence that IFN-α subtypes are not functionally redundant. Learn more: https://t.co/NbBPOZXuGw.

[The Journal of Immunology @J_Immunol]

November is #NationalDiabetesAwarenessMonth!

@J_Immunol invites submissions for our collection: Immunology of Diabetes, guest-edited by Barbara Nikolajczyk & Mary Markiwicz.

Submit original research on immune mechanisms in diabetes by Dec 31, 2027.

🔗 https://t.co/Ruk9tGdZRC

[The Journal of Immunology @J_Immunol]

Eager to get published fast? Don't fall for flashy email bait! Early-career researchers can easily slip into predatory publishing traps. AAI shares key tips to protect your hard-earned research: https://t.co/Tv5TNB9SHZ.

#PhDLife #PostdocLife #AcademicTwitter

[The Journal of Immunology @J_Immunol]

Data show the importance of macrophage high mobility group (HMG) nucleosome-binding proteins in maintaining tissue-specific gene expression and supporting inflammatory responses, providing clues to the phenotype of macrophages following alarmin secretion. https://t.co/0l57wJ3wGo.

[The Journal of Immunology @J_Immunol]

Early prostaglandin D2 (PGD2) production is associated with resistance to F. tularensis and B. pertussis in obese mice, suggesting PGD2 signaling may contribute to obesity-associated protection, helping identify novel host-directed therapeutic strategies https://t.co/fGCneCtQk2.

[The Journal of Immunology @J_Immunol]

Many peptide antigens are prone to form oxidation products. Researchers found oxidation resistant (OXR) antigens provide a strategy for eliminating sulfur oxidation products and improving the manufacturability and shelf-life of peptide-based vaccines. https://t.co/TF0UqBh765.

[The Journal of Immunology @J_Immunol]

Data show that T cell receptor-directed nanobodies with Vβ-restricted specificity enable cellular detection, inhibition of antigen-driven T cell activation, and immuno-PET/CT imaging of defined T cell populations in vivo. Learn how in The JI: https://t.co/poLJbPnMG9.

[The Journal of Immunology @J_Immunol]

Researchers develop a simple and effective gavage-fomite based method to generating “mice with natural microbiota.” Data supports broader use of these models in basic and translational immunological research across the field. Learn more: https://t.co/avKc5LN8Xn.

[The Journal of Immunology @J_Immunol]

Data establish the first allele-specific peptide-binding motif framework for canine MHC class II, providing a foundation for DLA-allele–informed CD4+ T-cell epitope discovery studies and antigen specific immune response characterization in dogs. https://t.co/Nn1icOUzzu.

[The Journal of Immunology @J_Immunol]

Researchers investigated the impact of TET2-driven clonal hematopoiesis of indeterminate potential on inflammatory bone loss and identified inflammatory bone loss associated with increased tissue infiltration of neutrophils, monocytes, and Th17cells. https://t.co/uIAGFo2B9d.

[The Journal of Immunology @J_Immunol]

Data reveal a previously unrecognized pathway in which the IL-33/ST2/SOCS1 axis suppresses NLRP3 expression to facilitate parasitic persistence during visceral leishmaniasis. Targeting this pathway is an opportunity for new therapeutics: https://t.co/ABMPGBOJZ5.

[The Journal of Immunology @J_Immunol]

Researchers identify Arid2 as a key regulator of peripheral B cell maturation and show that losing it produces stage-specific molecular and functional consequences that become more pronounced during hematopoietic reconstitution. Read more in The JI: https://t.co/JJ5GMS2XLG.

[The Journal of Immunology @J_Immunol]

A pilot clinical trial demonstrated that intravenous scopolamine, a muscarinic receptor antagonist, significantly improved #psoriasis by antagonizing elevated acetylcholine and blocking M1 receptor-mediated IL-23 release in dendritic cells. Learn more: https://t.co/DuPQ14yXM7.

[The Journal of Immunology @J_Immunol]

Data suggest that papaverine, an alkaloid, improves symptoms of #psoriasis through inhibition of proinflammatory cytokines and suppression of aberrant plasma cell differentiation, demonstrating its therapeutic potential. Learn more in The JI: https://t.co/3ZT7BouJCt.

[The Journal of Immunology @J_Immunol]

Data indicate that selenium is a promising immunomodulator adjunct that augments CD8+ T cell function and improves the response to anti-PD-1 therapy, suggesting it could be combined with immune checkpoint inhibitors for cancer treatment. Learn more: https://t.co/F2tM9Jit7k.

[The Journal of Immunology @J_Immunol]

Sublethal whole body irradiation impairs the kinetics, subset composition, and function of memory CD4 T cells, compromising their ability to mount effective recall responses to clear the infection, affecting patients with a history of radiation exposure. https://t.co/wqHEEZl5VM.