Real-world use of terlipressin for HRS-AKI in the US here.
➡️16-center (n=243 patients)
🔹 Overall Response: 55.1% 🔹 HRS Reversal: 30.9% 🔹 90-day mortality: 40.5%
➡️50% Extended Criteria (presence of ≥1 FDA warning) mostly 2/2 ACLF grade 3.
https://t.co/LTZqBjdTkK
To all new Ferrari fans ‼️
A quick reminder that these little moments of hope during testing could very well be the best moments of our year.
We drink the Holy Hopium. We rejoice in our capable drivers.
For next year is always our year.
Love,
A Ferrari fan for 35+ years
When used wisely albumin can help patients with cirrhosis says the best meta-analysis on this in @HepCommJournal
https://t.co/wKMh5zoXHw
But these trials are small and misuse - SO COMMON - outside of trials is harmful. How to thread the needle?
@JoeCullaro , our ⭐️ hepatologist (nephrologist in another life?), presenting his research on cystatin c's role in mortality prediction in patients with cirrhosis #livertwitter#GItwitter#TLM25
How common is ambulatory AKI (AKI occurring in an outpatient setting) in cirrhosis?
✅It’s common➡️1 in 8
✅Underrecognized➡️42%
✅Key precipitants➡️hypovolemia 2/2 diuretics & GI losses, & nephrotoxin medication exposure
✅Deadly➡️1 in 8 ☠️at 90d
🔥🔥https://t.co/imehINk3wv
Original Article
The relationship between mean arterial pressure and terlipressin in hepatorenal syndrome-acute kidney injury reversal: a post hoc analysis
Cullaro et al.
#LiverX
https://t.co/4ZWM6z63LX
What is the relationship btwn terlipressin & MAP
From the genius of @JoeCullaro
https://t.co/wjtcnR9oWR
🔥post-hoc analysis, patient-level data from REVERSE and CONFIRM.
🔥In a time dependent model, 5 mmHg ⬆️ in MAP was associated with 1.17x the hazard of HRS-AKI reversal.
@yuvalpatelMD@KavishPatidar11@ebtapper Agreed on all fronts, issue is 5L is not the same for all; definitely low MAP predispose to incident AKI, and so added protection in that group seems reasonable.
Learn to conduct clinical research with past AASLD presidents, lectures and sit down in round table discussions with Drs. Anna Lok, Vijay Shah, Jorge Marrero, and Gaudalupe Garcia-Tsao Monday at 2pm, 2 sessions! #TLM2024@AASLDtweets@JoeCullaro@BlaneyMD@Mironova_MD@DrLoomba