Jose A. Meade, MD

IM Res @BUMedicine - Incoming PCCM fellow @MayoClinic @MayoPCCM | Interests include but not limited to PCCM, #POCUS, meded and autoimmunity #RheumCrit 🩺⚕️

[Papa Heme @Papa_Heme]

Today's trainees pale in comparison

Dr Harrington, a fellow at WashU, thought ITP was due to a blood factor that caused destruction of platelets

To test hypothesis he took 500 cc 🩸 from a pt with ITP, injected it into himself, ended up hospitalized with severe thrombocytopenia

[Jose A. Meade, MD @JoseMeadeMD]

Congratulations for the next step from the MENTOR trial, the MAJESTY trial @fervenzaf

[NEJM @NEJM]

Presented at #ERA26:

In this 104-week trial involving patients with primary membranous nephropathy, the type II anti-CD20 antibody obinutuzumab was superior to the calcineurin inhibitor tacrolimus in inducing complete remission. Full phase 3 MAJESTY trial results: https://t.co/T3Z8pTEARK

@ERAkidney

[NephroPOCUS @NephroP]

Very interesting image of IVC!
Any guesses on what the red flow is? (clue: congenital anomaly) - See thread for source/full case.
#POCUS #echofirst #FOAMed

[NEJM @NEJM]

Figure 2 from a new Review Article shows the spectrum of extramuscular involvement in the four main groups of idiopathic inflammatory myopathy. 🔗 https://t.co/ZeCKdNe87v

Shown are the most common types of tissue involvement in idiopathic inflammatory myopathy. For each subgroup of myositis, the frequency of tissue involvement is shown on a bar chart. Respiratory involvement (nonspecific interstitial pneumonia or organized pneumonia) and skin lesions (erythematous) are the most common manifestations. The most common dermatological manifestations (erythematous or not) are heliotrope rash (dermatomyositis [DM]), Gottron’s papules (DM), shawl sign (DM), holster sign (DM), Raynaud’s phenomenon (DM, antisynthetase syndrome [ASyS], and overlap myositis), mechanic’s hands (ASyS), and calcinosis (skin damage). Digestive involvement is dominated by dysphagia. The presence of cancer of any type is common. Symptomatic cardiac involvement is rare and may be associated with ventricular dysfunction, arrhythmias, or conduction disorders. IBM denotes inclusion-body myositis, and IMNM immune-mediated necrotizing myopathy.

Learn more about inflammatory myopathies: https://t.co/ZeCKdNe87v

[Orlando RPN @OrlandoRPN]

Nuestro último estudio publicado: https://t.co/K8IXZ1tp0p

En pacientes con obesidad sometidos a anestesia general, programar el Vt por peso ideal (OMS) o por peso predicho, no generaron diferencias significativas en la Driving Pressure

Estudio comandado por @DiegoEscarraman

@vm_aventho #AVENTHO 🫁

[NephroPOCUS @NephroP]

Pathophysiology of right-sided heart failure.
#FOAMed #Nephpearls

[Juan Manuel Mejía @Meyaix]

With the results of BAXHTN study published in @NEJM (https://t.co/UWEcGjtRxv). Baxdrostat (aldosterone synthase inhibitor - ASI) is now FDA approved for the management of hypertension. https://t.co/lsXWZFtl4a Ongoing studies (BaxDuo Arctic and Pacific) for chronic kidney disease

[Jose A. Meade, MD @JoseMeadeMD]

Muchas gracias por la invitación 🙌🏻
Nos vemos este viernes en el 1er congreso latinoamericano de cuidados intensivos!!

[Orlando RPN @OrlandoRPN]

Posiblemente la persona que sabe más de enfermedades autoinmunes en pacientes críticos en todo Latinoamérica, Médico Internista en Boston 🇺🇸, investigador de la Clínica Mayo, con múltiples estudios al respecto y reportes de Casos Ratos, además de una revisión sistemática de hemorragia alveolar difusa por Sx Antifosfolípidos y otra sobre hemorragia suprarrenal, el Dr. José Antonio Meade-Aguilar hablará sobre Hemorragia Alveolar Difusa, abordaje y tratamiento

@JoseMeadeMD

[Sanjeev Sethi @SethiRenalPath]

Unusual presentation of MPO and pANCA-vasculitis, this week.

Typical presentation is a pauci-immune necrotizing & crescentic glomerulonephritis.

However, none of 20+ glomeruli in biopsy sample showed crescents.

But= Massive necrotizing arteritis in one core (got lucky), plus granulomatous interstitial nephritis.

Diagnosis: Necrotizing arteritis, likely associated with pANCA/MPO vasculitis.

The findings are unusual- more likely to see this lesion in PR3/cANCA vasculitis.

History: 70 year-old man with rapidly progressive renal failure.  Serum creatinine 5.5. Positive MPO and p-ANCA titers.

[Papa Heme @Papa_Heme]

Sad I have to remind some doctors that shared decision making does NOT mean present them with a bunch of options and have the patient choose.

[Jose A. Meade, MD @JoseMeadeMD]

@MayoClinicNeph @OscarGarciaMD Congratulations, Oscar!

[Gianrico Farrugia @GFarrugiaMD]

Rosa Rademakers, PhD, has received the 2026 Breakthrough Prize in Life Sciences for work carried out at Mayo Clinic, one of the most prestigious awards in science. Read more: https://t.co/g49gqbXO14

[NephroPOCUS @NephroP]

Latest post on https://t.co/5dIBLwYhWN -
“Not Every Dilated IVC or Pulsatile Portal Vein Is Pathological”
#POCUS #Nephpearls #echofirst
🔗 https://t.co/p6zEzOhuel

[Keith Siau @drkeithsiau]

3D Endoscopy is here 😍😎

[Tony Breu @tony_breu]

1/14
Why can't you use direct oral anticoagulants (DOACs) in patients with mechanical valves (MVs)?

DOACs have been one of the most important advances in my career. And yet, the presence of a MV is one of the few contraindications.

The reason highlights the unique nature of thrombus formation in those with a MV and provides insights into the evolution of human hemostasis.

[Eric Topol @EricTopol]

At @JAMA_current today, 2 radiologists publish what should be the consent form for a total body MRI in healthy people
Note: "no major medical society recommends whole-body MRI screening in the general population because it is unproven, and the harms likely outweigh the benefits."
https://t.co/TRSkxDwb6K

[Jose A. Meade, MD @JoseMeadeMD]

Bradykinin is an amazing molecule. Intersection between inflammation cascade, coagulation cascade, complement system AND RAAS system!
Imagen generated with GPT.

[ANDROMEDA-SHOCK @AndromedaShock]

ANDROMEDA-SHOCK-2 selected by JAMA as trial of the year 😍😍😍😍😍😍😍😍😍😍😍 https://t.co/OlGeofxTpu

[Eric Topol @EricTopol]

On the lack of compelling evidence that medical AI is improving patient care, and what to do about it, a @NatureMedicine editorial https://t.co/kQiN6L2ai7

[Bishal Gyawali, MD, PhD, FASCO @oncology_bg]

A MUST-READ!

This is probably one of my most important papers where I try to teach how to fish rather than offer fish.

How I Read a Clinical Trial Report?

BG’s primer for Busy Clinicians.

Thank you @JCOOP_ASCO @EthicsdoctorP for the kind invitation. I hope the readers will find this useful.

https://t.co/HJhZlsBpU2