Our dear @KateDicker4 is leaving for a new adventure. Despite a pandemic & a lab move from @BiochemOxford to the @CVRinfo , she completed an excellent PhD and discovered a cellular protein that regulates HIV particle formation (stay tuned for the paper). We will miss you! ๐๐ฅฒ๐ฅ
๐งตWe also elucidated the interactome of #Rev in HIV infected T cells. We show that many of the proteins that are packaged with the #HIV genome interact with Rev in the nucleus, likely remaining associated with the viral RNP until they are assembled into virions.
New preprint from the @castello_lab, showing that #HIV packages its genome with over 100 cellular #RBPs into viral particles. These proteins can play critical roles, e.g., PURA and PURB binds to key elements in HIV genome and enhances virion infectivity https://t.co/XWFV9GAnVc
Congratulations to @KateDicker4 that defended her PhD thesis on the discovery of new regulators of HIV infection, working in the @castello_lab and Sattentau lab ๐๐ฅณ๐ฅณ๐ฅณ. Time to celebrate ๐ป๐ป
Great talk by @KateDicker4 from the @castello_lab on host RBPs that are encapsidated with the HIV genome! Unanticipated associations with interesting mechanisms that govern viral pathogenesis @RNASociety#RNA2022
An article I wrote on how yeast is being used to fight global health challenges has been published by @oxsci ๐ here's the link if you'd like to give it a read: https://t.co/r6MtYrshac