Keith Dredge

Drug Development Professional committed to translating science into tomorrow's medicine. Opinions are mine. 🇮🇪🇦🇺

[Keith Dredge @KeithDredge]

@AppleHelix Here in Aus, there is an exemption for FIH Ph1 trials relating to TGA manufacturing licence/inspection. GMP is not ignored & most align to PIC/S. A CMC advisory says all his Phase 1 clients made FIH batch under GMP. As for GLP tox, it’s same as US, but no SEND or IND, just IB

[Keith Dredge @KeithDredge]

@learnbiotech @McKinsey In 2011, precision medicine in oncology meant sales force almost obsolete https://t.co/QMIeqjopcm Rare disease is also high for precision med & has patient advocacy (investment not req’d for some). Are launches more successful for precision medicines in well defined populations?

[Life Sciences Queensland Ltd (LSQ) @LSQld]

Queensland Life Science Sector Survey - Closes 1 March 2023! LSQ has teamed up with @KnightFrank who are specialists in this real estate sector and are developing a tool that will assist the sector to bridge this gap. Read more https://t.co/nZm1llCrrI

[Keith Dredge @KeithDredge]

Great to see these data published @jitcancer

[Journal for ImmunoTherapy of Cancer @jitcancer]

New #JITC article: Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with MSS metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors https://t.co/80YzKxKa6C @KeithDredge

[Keith Dredge @KeithDredge]

Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors https://t.co/TPa3Hx1k1d

[Keith Dredge @KeithDredge]

Thanks to @diwakardavar for highlighting the ongoing clinical trial using #pixatimod @UPMCHillmanCC @sitcancer 2022

[Diwakar Davar, M.D. @diwakardavar]

Novel TLR9 agonist pixatimod with Nivo in multiple solid tumors ⁦⁦⁦@sitcancer⁩ 2022. ⁦@UPMCHillmanCC⁩ ⁦@ZuceroT⁩

[David Langsam @biotech_daily]

Dr Paul Kasian Replaces @ZuceroT Chair Dr Steffen Nock; Us Patent - subscribe to Biotech Daily https://t.co/4E9331THtC

[@gulleyj1 @gulleyj1]

"Never let a good crisis go to waste" Churchill. As quoted by Dr. Feltquate. Did you know the fastest time to trial activation is #Australia? Proud of those Aussies! And let's figure out how to improve efficiency here! https://t.co/9MtJx0fMrU

[Keith Dredge @KeithDredge]

@ProfPaulYoung Had ‘razor blade’ throat too a few months ago. So painful. Ended up in ED and had CT scan of throat, given dexamethasone and was much better 48 h later. Also no lower respiratory issues which kept me calm as vaccine was doing it job but that throat😫 get well soon

[Keith Dredge @KeithDredge]

@Caroline_Bartma Some good points made here https://t.co/L96TXTpw2x

[Keith Dredge @KeithDredge]

@marklewismd And regulators wouldn’t appreciate these drug claims now (from Scotland’s worst poet😉)

https://t.co/1Ejjral16f

[Keith Dredge @KeithDredge]

@CheckmatePharma @Regeneron Exciting news, congratulations!

[Keith Dredge @KeithDredge]

@pashtoonkasi @TheLancet Excellent work, thank you for sharing.

[Keith Dredge @KeithDredge]

A tremendous national and international effort to publish our exciting data on #pixatimod as a potential therapeutic for #COVID19 thanks to all our collaborators!

[Keith Dredge @KeithDredge]

@whereisdaz As someone developing a heparan sulfate mimetic, it was not a “crazy idea” to test heparin’s anti-viral properties. Very obvious. But some referenced preclinical data (& PK data!) would be nice to see in order to support the claims in a news piece! (Then there’s GLP tox)

[Journal for ImmunoTherapy of Cancer @jitcancer]

Dec @sitcancer #JITC Editor reading list Dr Melief @tronmainz #4 @CD_AACR Overcoming PD-1 Resistance w CpG-A TLR9 Agonist Vidutolimod in Melanoma @ToniRibas12 @ZakhariaYousef @diwakardavar @CampKatiee @RiyueSunnyBao @jasonlukemd @ArtKrieg @MelanomaIowa
https://t.co/8DPP3V2luU

[Dr Darren Saunders @whereisdaz]

I’ve seen this play out in the most distressing way. Disease is rarely determinant, bad luck has a lot to with it and implying otherwise to unwell people (deliberatley or accidentally) is un helpful and upsetting. Don't do it.
Big wellness has a lot to answer for...

[Keith Dredge @KeithDredge]

Our #pixatimod abstract @sitcancer #sitc2021 is now out! Proud to be involved in development of this Queensland/Australian technology @ZuceroT @LSQld @AusBiotech https://t.co/y8ArtvTsoA

[Keith Dredge @KeithDredge]

As an industry scientist, I agree 100% & such funding should available from ARC & NHMRC etc for academic basic science projects

[Dr Darren Saunders @whereisdaz]

Everyone is obsessed with “translational” and applied research, which have an important role. But without the discovery science, there’s nothing to translate or apply!