qPCR allowed us to measure transcripts, but just once, destructively, and only in post-mortem tissues. Here, we show we can record transcript level history in vivo and recover this information with a blood test to make a "noninvasive qPCR". https://t.co/fe6yjsrdGr
Excited to share that our AzoTag paper is now out in @NatureChemistry! 🥳
We demonstrate de novo chemo-optogenetics through the rational design of photoresponsive small molecules and selection of their artificial protein binding pairs.
https://t.co/Rtjc3irDS3
📢 Our new paper has been published in Journal of Biomedical Optics!
The collaborative research team, including our group (School of Science, Kitasato), Dr. Toshihide Matsumoto (School of Allied Health Science, Kitasato), and Prof. Takahiro Kuchimaru (Jichi Medical University), has experimentally demonstrated the optical detection of cancerous cells (dysplasia) beneath a healthy layer using the circularly polarized light scattering (CiPLS) method.
This method utilizes the optical scattering phenomena of circularly polarized light.
This innovative approach could significantly enhance early detection and treatment strategies for cervical cancer, potentially improving patient outcomes.
Their findings were recently published in the Journal of Biomedical Optics on February 6th, 2026, and the scientific illustration of the study was selected as a cover artwork in this journal.
Circularly polarized light scattering imaging of a cancerous layer creeping under a healthy layer for the diagnosis of early-stage cervical cancer
https://t.co/Xc0n2UtUNY
Full press release available here: https://t.co/PS0XYyzGJz
And the scientific illustration of the study was selected as a cover artwork in this journal.
#KitasatoUniversity #JichiMedicalUniversity
#BiomedicalOptics #CircularlyPolarizedLight #CervicalCancer #CIN #Biophotonics #EarlyDetection #CancerDiagnosis #OpticalBiopsy
I am excited to share our latest preprint, in which we demonstrate that systemic hypoxia suppresses solid tumor growth.
This has been a tremendous collaborative effort in the labs of @IshaHJain and @Genophoria at @GladstoneInst, @ArcInstitute, and @UCSF.
https://t.co/bzsPY2nWVs
Check out our platform for studying energy metabolism in cardiology! We've established a murine cardiac fibroblast stably expressing GO-ATeam2, a genetically encoded FRET ATP sensor. If you’re interested in this cell line, please feel free to contact me. https://t.co/MYtRbe7Td1
I am deeply saddened by the sudden news of Dr.Yoshihiro Ohmiya. His pioneering work on bioluminescence imaging— BRET design to immuno BLI, as well as the identification of many lucierases such as Cypridina luc and Emerald luc—has been a profound source of inspiration for me.
Excited to share our paper on 'MT-Bundler' that induces intracellular #microtubule bundling on bioRxiv!
https://t.co/nywOZ4T2ij
MT-Bundler, consisting of microtubule-binding motifs and a tetrameric protein, cross-linked microtubules and conferred marked stability and acetylation.
Our new work with Kyoto University is out in Angewandte Chemie: microcondensates enable LNP-free mRNA delivery and achieve in vivo protein expression for the first time. A new direction for mRNA therapeutics.
https://t.co/zru9OzUWss