lka_

Hematology and medical oncology fellow at Thomas Jefferson University Hospital.

[lka_ @lka_]

@erastourticks How are people in a queue

[lka_ @lka_]

#ASCO14

[lka_ @lka_]

#ASCO14

[lka_ @lka_]

4% improvement in 5 yr OS in exemestane +OFS arm vs tamoxifen +OFS in premenopausal women with early breast cancer #ASCO14

[lka_ @lka_]

Including testing for 10 SNPs associated with breast cancer to GAIL model increases predictive value. Dr. Yang. #KCCBreast14

[lka_ @lka_]

Dr. Simone reports radiation therapy more effective when done with caloric restriction in mouse model. #KCCBreast14

[lka_ @lka_]

Highest incidence of breast cancer is age 45 in Korea. #KCCBreast14

[lka_ @lka_]

Dr. Klassen talks about the changing epidemiology of cancer, with greater increases in incidence in developing countries. #KCCBreast14

[lka_ @lka_]

AA women present at younger age, have more advanced stage rumors at presentation and more biologically aggressive rumors. #KCCBreast14

[lka_ @lka_]

Dr. Mitchell: disparities in cancer; AA women have a lower incidence of cancer but higher cancer death rate than white women #KCCBreast14

[lka_ @lka_]

Dr. Thakur describes over-testing assoc with abnormal mammograms with $30 billion cost to health care system.#KCCBreast14

[lka_ @lka_]

Dr. Woodward describes phase I trial of parp inhibitor w/ RT after mastectomy, she notes parp inhibitors are radio-sensitizers #KCCBreast14

[lka_ @lka_]

Dr. Avery discusses history of parp inhibitors and importance of choice of chemotherapy backbone. #KCCBreast14

[lka_ @lka_]

Dr. Avery discusses similarities btwn triple negative and BRCA assoc. breast cancers which leads to treatment similarities. #KCCBreast14

[lka_ @lka_]

Dr. Pestell describes presence of CCR5 in oncogene transformed prostate cancer and use of blockade of this receptor with HIV drug in mice.

[lka_ @lka_]

@lka_ CCR5 ligand and receptor

[lka_ @lka_]

Dr. Pestell's study demonstrated CCR5 inhibitors blocks basal breast cancer mets in preclinical models. #KCCBreast14

[lka_ @lka_]

Dr. Pestell describes increased ligand and receptor production in breast cancer, may be a target for therapy. #KCCBreast14

[lka_ @lka_]

Dr. Fatatis' project with CX3CR1 inhibitor reduces seeds for potential metastasis, demonstrating fewer bone mets in mice model #KCCBreast14

[lka_ @lka_]

Dr. Fatatis working on a project injecting labeled CTC-like cells, watching their migration and proliferation. #KCCBreast14