TheNandadasaLab

Primary Cilia and Extracellular Matrix Lab at The University of Massachusetts Medical School -Department of Pediatrics

[TheNandadasaLab @LabNandadasa]

With special thanks to @AtukoralePU lab and the whole team for their efforts in completing this study, here we reveal that "Loss of ADAMTS9 results in Nephronophthisis like polycystic kidneys by disrupting ciliogenesis and ECM dynamics" https://t.co/MNNMnCPS91

[TheNandadasaLab @LabNandadasa]

Delighted to share the publication of our work related to TMEM67 cleavage today. This is the first of three related manuscripts on the topic, thanks to a great team of collaborators from UMass and Europe.
https://t.co/pGbgYSGqzG

[TheNandadasaLab @LabNandadasa]

3rd year graduate student Sydney Fischer being the flag bearer for the lab in Dublin at #Cilia2024

[TheNandadasaLab @LabNandadasa]

@KarenL_PhD Hope you got to meet Sydney representing the lab at the meeting!

[TheNandadasaLab @LabNandadasa]

Biologically validating a mass spec predicted cleavage of any protein using a novel mouse model is quite rare. However, what made this study extraordinarily unique is ciliopathy patients with TMEM67 variants of the cleavage residues identified, which we modeled in C elegans.

[TheNandadasaLab @LabNandadasa]

Vey excited to unveil our work identifying the TMEM67 extracellular domain cleavage site. This is the first ciliary structural protein cleavage site identified using N-terminomics and validated in humans, mice and C elegans. https://t.co/nI0SzwoIkE

[TheNandadasaLab @LabNandadasa]

Our latest work identifying novel ADAMTS9 substrates utilizing N-terminomics is now in press..
https://t.co/97f4RluDMG

[TheNandadasaLab @LabNandadasa]

Speaking of mega droughts and watering lawns, here is a perfectly manicured (and watered) #cilialawn.

[TheNandadasaLab @LabNandadasa]

@Missingh_Mukti @baldocklab Congratulations Dr. Singh! Where to next?

[TheNandadasaLab @LabNandadasa]

@ReiterLab Interesting RGD (SLiM) variant at 405. Wonder if this variant enhances integrin binding…

[eLife - the journal @eLife]

Researchers have tested how designer transmembrane proteins can control engineered receptors: https://t.co/PL9MkXGHFy

[TheNandadasaLab @LabNandadasa]

Excited to share our grant proposal with the @AtukoralePU lab to Develop a targeted mRNA encapsulated Lipid Nanoparticle for The Treatment of Polycystic Kidney Disease has been selected for funding supported by the NIH National Center for Advancing Translational Sciences. #Cilia

[TheNandadasaLab @LabNandadasa]

@KarenL_PhD Wanna move to US and continue to work on TMEM67? 🙂

[TheNandadasaLab @LabNandadasa]

@KarenL_PhD Happy holidays and merry Christmas to you (and Oliver as well)!

[TheNandadasaLab @LabNandadasa]

We are recruiting the following positions!
https://t.co/UDVZZjAhHd

[TheNandadasaLab @LabNandadasa]

@DebsSeifert @NIHFunding @UMassChan Thank you! Hope all is well in CLE

[TheNandadasaLab @LabNandadasa]

Delighted and rejoicing while humbly being thankful to all the past mentors, students, collaborators and colleagues whose contributions were invaluable to make this a reality. Thank you @NIHFunding @UMassChan #FirstR01

[TheNandadasaLab @LabNandadasa]

@ToobaQuidwai @NIHFunding @UMassChan Thank you Tooba! Hope we get to celebrate soon.

[TheNandadasaLab @LabNandadasa]

Some collaborations are more fruitful than others. Here’s our latest collaboration project with the Atukorale lab @AtukoralePU thanks to @umassmemorial

[TheNandadasaLab @LabNandadasa]

While being optimistically cautious, no words can ever describe the exhilaration the below numbers brought, when your first R01 gets reviewed as such. Thank you NIH and the NIDDK scientific reviewers for this moment!