Handling patients is very interesting. You offer patients drugs or rather administer all drugs in time n fail to listen to them, you end up being the patient's problem
🔲MONTELUKAST REVIEW.
What is Montelukast?
🔶Montelukast is used in the maintenance treatment of asthma. It's also used to treat allergic rhinitis. It is not useful for acute asthma attacks.
🔶It works as a leukotriene D4 inhibitor in the lungs, resulting in decreased inflammation and relaxation of smooth muscle.
🔶Common side effects include abdominal pain, cough, and headache. Less commonly, montelukast can cause eosinophilia and anaphylaxis.
🔶Taken by mouth.
⚠️BLACK-BOX WARNING.
Montelukast has a black-box warning due to its risk of causing serious neuropsychiatric effects.
🟣Pharmacokinetics.
🔸Bioavailability: 63–73%
🔸Protein binding: 99%
🔸Metabolism: Liver, primarily CYP 2C8
🔸Elimination half-life: 2.7 – 5.5 hours
🔸Excretion: biliary
🛒Brand: Singulair ®
⚫️Non-Selective Beta-Blockers and Asthma.
Non-selective beta-blockers are avoided in patients with asthma due to the risk of life-threatening bronchospasm.
Examples:
🔸 carvedilol
🔹 labetalol
🔸 nadolol
🔹 penbutolol
🔸 propranolol
🔹 pindolol
🔸 sotalol
🔹 timolol
Schematic drawing of the three-neuron oculosympathetic pathway. Do you know the most common lesions affecting these regions?
Credits: Sung-Hee Kim
#MedTwitter
Infantile Hemangioma
Etiology and Pathogenesis:
Infantile hemangioma is a benign vascular tumor that occurs in infants.
The exact cause of hemangiomas is not well understood, but it is believed to involve abnormal growth of blood vessels.
It is thought to be a result of genetic factors and hormonal influences during pregnancy.
Clinical Features:
Infantile hemangiomas typically appear as raised, red or purplish lesions on the skin.
They can vary in size and shape and often have a rubbery texture.
Hemangiomas commonly occur on the face, scalp, trunk, or extremities.
They tend to grow rapidly during the first few months of life and then gradually shrink and disappear over time.
Some hemangiomas may cause complications if they occur in certain locations, such as near the eyes, nose, or mouth.
Treatment:
1. Observation: Many hemangiomas will naturally shrink and disappear without intervention.
2. Medications: Certain medications, such as beta-blockers or corticosteroids, may be prescribed to help shrink the hemangioma.
3. Laser therapy: Laser treatment can be used to reduce the size and color of the hemangioma.
4. Surgical removal: In some cases, surgical excision may be necessary if the hemangioma is large or causing significant complications.
FAQS:
1. Can infantile hemangiomas cause any complications? Infantile hemangiomas can sometimes cause complications if they occur in certain locations, such as near the eyes, nose, or mouth. They may affect vision, breathing, or feeding in such cases.
2. Will the hemangioma leave a scar after it resolves? In most cases, infantile hemangiomas do not leave a scar once they have completely resolved. However, if the hemangioma was large or required surgical removal, there may be a risk of scarring.
3. Can infantile hemangiomas recur after treatment? Recurrence of infantile hemangiomas is rare but can occur in some cases, especially if the treatment was not completely successful. Regular follow-up visits are important to monitor for any signs of recurrence.
4. Are there any long-term effects of having an infantile hemangioma? In most cases, infantile hemangiomas do not have any long-term effects on the child's health. However, if the hemangioma caused complications or required extensive treatment, there may be some residual effects.
5. Can infantile hemangiomas be prevented? There is currently no known way to prevent infantile hemangiomas. They are believed to occur due to genetic and hormonal factors during pregnancy.
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