Leeds Integrative Membrane Biology

An interdisciplinary research theme in the School of Biomedical Sciences at the University of Leeds, focussing on membrane proteins in health and biotechnology.

[Pliotas Group @PliotasGroup]

In our latest article we found structural correlation between pocket modification and tension activation in the MscL channel using pulsed EPR, HDX and MD: https://t.co/ROpCECbiXb
@Bolin83814396 @95bjl @anton_calabrese @FrankSobott @KalliGroup @EPR_ESR @RSC_ESR @AstburyCentre

[Pliotas Group @PliotasGroup]

Check out our new preprint: Mechanical and molecular activation lead to structurally analogous MscL states https://t.co/xvlHHLQOrw
Great effort by @Bolin83814396 & @95bjl, @FrankSobott @anton_calabrese @KalliGroup at @AstburyCentre @ScienceLeeds @LeedsIMB @MassSpecLeeds

[Stephen Muench @stemuench]

Took a while to get around the preferred orientation of HSPD1 but good to see the hard work of @DavidKlebl and the team @MatthewFeasey @HeskethEmma @RSBon_Lab @naranson @FrankSobott finally out. https://t.co/rHq4O7Lh45

[Jannik Strx @Jannik_Strx]

So excited to see IMPROvER finally published!!! First first authorship together with @Steve_Harborne and @JessicaJCB_ 🍾 Give it a go and stabilise your most loved/hated membrane protein :)
https://t.co/TxBw6idvot

[Biophysical Journal @BiophysJ]

#OPENACCESS: "In-Lipid Structure of Pressure-Sensitive Domains Hints Mechanosensitive Channel Functional Diversity" by Charalampos Kapsalis et. al. https://t.co/Yrf86SZGFp @PliotasGroup @Bela_Bode @mayue3691 @LeedsIMB @AstburyCentre @ScienceLeeds @StAndrewsBSRC

[Stephen Muench @stemuench]

It started out as a 10 week rotation project looking at particle behaviour in the ice, over 1 year later we finished it! Thanks to lots of people @DavidKlebl @Bex_16 @MDarrow7 @Molly_Gravett @michkouros @DCFMonteiro and more.. https://t.co/P66lWAM9cL

[Jon Lippiat @DrJonLippiat]

It's published! #ionchannels #kcnt1 #epilepsy @Beth_aimee_cole @RachelJ9908 @jeff_dddd @FishwickGroup @stemuench

[Robin Bon @RSBon_Lab]

Very proud to share the first #CryoEM studies by our @UoL_LICAMM @AstburyCentre #TRPC team: Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site. https://t.co/gzbiuDU6P3

[Goldman Lab @GoldmanLab]

We’ve got an exciting #postdoc opportunity working on #membraneprotein #structuralbiology in close collaboration with @LarsJeuken @PliotasGroup and Dr Antreas Kalli!

Check it out here and please encourage anyone that could be interested to apply:
https://t.co/k4vMoMXwv5

[Goldman Lab @GoldmanLab]

Excited to announce that the Goldman Lab will be coming to Public Engagement Events Near You in March 2020 #AstburyConversation20 #BeCurious20

[Leeds Integrative Membrane Biology @LeedsIMB]

A cryo-EM grid preparation device for time-resolved structural studies https://t.co/YQkKKpqFwJ

[Leeds Integrative Membrane Biology @LeedsIMB]

New publication from Integrative Membrane Biology by @PliotasGroup and @DrJonLippiat

[Pliotas Group @PliotasGroup]

Pleased to see our study in @NatureComms. We show the high threshold mechanosensitive channel could be allosterically modulated
https://t.co/4Ywm3cpr84

@AstburyCentre @LeedsIMB @IonChannelLeeds @Bela_Bode @DrJonLippiat @StAndrewsBSRC @ScienceLeeds @SchoolofBiology @news_RSE

[Pliotas Group @PliotasGroup]

Great cover image by Dario de Vecchis and @antreaskalli group for their study on Band3 featured in Biophysical Journal @AstburyCentre @LeedsIMB

[Goldman Lab @GoldmanLab]

our final year @wellcometrust phd student ROTOR thesis!! Congratulations @brendanfarrell #thesistheend

[Leeds Integrative Membrane Biology @LeedsIMB]

New #preprint from our Integrative Membrane Biology group.

[Jon Lippiat @DrJonLippiat]

First #preprint alert. Are cryo-EM structures any good in virtual HTS for ion channel modulators? #KCNT1 #ionchannels #epilepsy @beth_aimee_cole @RachelJ9908 @stemuench @jeff_dddd @FishwickGroup @AutifonyLtd

https://t.co/1chJpoGhvr