Marco Sciacovelli

Tenure Track Fellow (Group Leader) at @LivUniISMIB. Studying cancer metabolism, mitochondria, metabolite signalling. Views are my own.

[Dylan Ryan @RyanLab_TCD]

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️

https://t.co/ER96q8gQbk

Interesting finding:

Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke

[Nature Metabolism @NatMetabolism]

RESEARCH | Yao, Shao, Shan, Wu et al. (Zhejiang U)

A distinct lipid-laden subset of monocyte-derived macrophages regulates hepatocyte proliferation and liver regeneration in injured livers, via CD36-mediated signalling.

https://t.co/QI3b4LJyZX

[Nature Metabolism @NatMetabolism]

Often forgotten but essential: long-chain acyl-CoAs in metabolic control https://t.co/cCt8Dp6lht

[Dylan Ryan @RyanLab_TCD]

📢 Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️

https://t.co/2EUxbvHJqY

Interesting finding:

Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis

[Sofia Costa @ASofiaHCosta]

Happy Sunday! Here are the most recent issues of bims-metlip, chock-full of new analytical and computational methods for #metabolomics and #lipidomics

https://t.co/ktn0e18Jim

https://t.co/DPG6tqgUdr

Brought to you in collaboration with @Bims_BiomedNews

[Nature Metabolism @NatMetabolism]

#NatMetabPicks | In @Nature led by RK Jain, @geochurch & @mvh_lab (@Harvard)

This work highlights the complexity of metabolic dependencies in metastatic site selection.

https://t.co/yQSY9ZxxAc

[Cell Press @CellPressNews]

An update to the Hallmarks of Cancer framework for understanding (and researching) what causes human cancers. https://t.co/3d6pYrcAJ5

Douglas Hanahan
@CellCellPress

[Dylan Ryan @RyanLab_TCD]

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️

https://t.co/FelTgrn2SC

Interesting finding:

Spatiotemporal regulation of energetic charge dictates T cell function @NatureComms

[Jason R. Cantor @JasonRCantor]

For nearly a century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @NatMetabolism, led by @thebioKIMist! Leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q 🧵

[Dylan Ryan @RyanLab_TCD]

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️

https://t.co/zkvlIKD2s8

Interesting finding:

Albumin orchestrates a natural host defence mechanism against mucormycosis

[CRUK Scotland Inst @CRUK_SI]

🆕Paper in @NatureGenet from Georgios Kanellos in @owen_sansom's lab: Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation https://t.co/Ht4RFtdv9W

[Cancer Discovery @CD_AACR]

Now online: The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer https://t.co/WGiHTZgEn2

[Molecular Cell @MolecularCell]

Online Now: Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria https://t.co/dQW1geDuw7

[Nature Metabolism @NatMetabolism]

RESEARCH | F Kaluba, EC Lien et al. (@VAInstitute):

Cancer cells can reroute ketones to produce cytosolic acetyl-CoA and support tumour growth.

https://t.co/y0uGLJZD3O

[Dylan Ryan @RyanLab_TCD]

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️

https://t.co/uRFtpjz39g

Interesting finding:

Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation

[Dylan Ryan @RyanLab_TCD]

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️

https://t.co/hMdfwUKac6

A huge collection inside!

Interesting finding:

Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity

[Dylan Ryan @RyanLab_TCD]

📢Last 2 weeks of #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️

https://t.co/u7ZQxQZUxi
https://t.co/s6dLENtnyE

Exciting to have a paper in the collection!

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice

[Marco Sciacovelli @MSciacovelliLab]

Great work from Suzan Ber and Alessandro Esposito regarding the metabolic reprogramming driven by different KRAS mutation in colorectal cancer. Thank you for involving me in this cool project! https://t.co/OHG0Ip0IBb

[Dylan Ryan @RyanLab_TCD]

Last week's #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️

https://t.co/RV8ljlg5yQ

Interesting finding:

Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses

[Nature Metabolism @NatMetabolism]

Reawakening cAMP signalling in cancer cachexia https://t.co/GS63rSquZI