Marcin L Pekalski

life scientist: molecular biologist, immunologist,
cell ecologist, macrophage behaviorist, phage breeder and wild microbiome archivist;

[Marcin L Pekalski @MarcinPeka]

@assert_pub @ProfJohnATodd https://t.co/qfVaVysMDs
We propose #T1D is primarily caused by immune responses against microbial-enzyme transketolase which contains key insulin-epitope. Our findings link microbial metabolism of polysaccharides, dysbiosis and antigen-specific immune responses to insulin.

[Marcin L Pekalski @MarcinPeka]

@SciImmunology @washu_pathology What about the role of microbial chitinases from the airway/lung #microbiome? Can ,#lung_microbiome signatures of chitinase expression predict outcomes, which microbes are protective here?

[GutMicrobiota Health @GMFHx]

Microplastics are everywhere.

This timely editorial in @NatureMedicine calls for an urgent deeper understanding of the effects of these particles on human health:

https://t.co/vPLvMhFwIr

[Science Immunology @SciImmunology]

When it comes to #thymus protection against autoimmunity, producing normal thymic regulatory T cells is more important than deleting self-reactive T cells, @UZH_en researchers conclude from studies in mice.

Check out the 2021 research: https://t.co/0l7Mh9Yn7j #WeekendReads

[John Lukens @LukensJohnR]

Smoking changes adaptive immunity with persistent effects. 🚬 https://t.co/VY5BFtTOLl

[Department of Paediatrics @OxPaediatrics]

Get it while it's hot! The newest @NatureComms publication on thymic epithelial cells by @FabianJKlein from the Holländer lab at @IdrmOxford @UniofOxford is now online:
https://t.co/h0ngtGtdgc

[The Journal of Immunology @J_Immunol]

#CuttingEdge from @MelicharLab and John H. White @mcgillu | #Autoimmune regulator #Aire is a coactivator of the #VitaminDReceptor
#ReadTheJI #immunology 👉 https://t.co/1RGiSA0Ie4

[GutMicrobiota Health @GMFHx]

New research suggests antimicrobial used to promote livestock growth breeds bacteria more resistant to our natural defences.

These findings add to the current body of evidence on the negative impact of antibiotics beyond the gut:

https://t.co/kxGRIayUT2

[BLYSKAVKA @blyskavka_ua]

⚡️Residents of Kherson region, save your pets from drowning - the Ministry of Internal Affairs of Ukraine

"If you evacuate, take care of pets: unchain them, let them out of their cages or, if possible, take them with you. Give the furry ones a chance to be saved," the message says.

👉 Follow @Flash_news_ua

[Irina Stefana @irina_stefana]

Do you work in biomedical #research? Do you also question your #antibodies? Dodgy antibodies waste time & $$$ + drive the reproducibility crisis. Let's talk about it!

We've validated >50❗️Tau antibodies: https://t.co/KFbcYOoFUB

Here's what we learnt & why it matters

A 🧵 1/n

[Science Magazine @ScienceMagazine]

In Australia, the southern greater glider population’s habitat could be destroyed by logging.

"To protect this species, we must prevent further logging of Australia’s native forests," argues a new #LetterToScience. https://t.co/eDid9KkWFT

[biohub @biohub]

By 2050, an estimated 152 million people will affected by dementia globally. @uk_biobank ’s repeat imaging project could provide crucial information that may assist with diagnosis and treatment of #Alzheimers and related conditions https://t.co/6pRB77Qw5u

[Pádraic Fogarty @whittledaway]

We've been robbed

The wildlife we have today is merely a wisp of it should be

[Magdalena Skipper @Magda_Skipper]

Wax worm saliva can oxidise and depolymerise polyethylene, one of the most produced and sturdy polyolefin-derived plastics @NatureComms #plasticpollution https://t.co/x7HnO2Xd8G

[Vala Afshar @ValaAfshar]

Here is how Finland is designing the perfect school 🇫🇮

[Paul Lewis @paullewismoney]

Nick Newman in today’s Sunday Times

[eLife - the journal @eLife]

The tongue is a unique barrier organ constantly exposed to environmental pathogens. Researchers have mapped the immune cell network of the tongue during development, health, and disease. https://t.co/EC2YR5fq9q

[Science girl @sciencegirl]

In the Zagros mountains of Iran, perfectly blended into the gypsum and limestone rocks is a snakes entire body

but the tip of its tail which resembles a spider, luring insectivorous birds within striking range. This is the spider-tailed horned viper 1/🧵

[Everest Today @EverestToday]

Check out this incredible avalanche footage from the Tian Shan mountains in Kyrgyzstan. Luckily, everyone survived. Account: https://t.co/amo4Bh6z8I

[Science Immunology @SciImmunology]

A new study in mice suggests that a majority of IgA in the gut is selected to recognize and react to distinct gut bacterial species instead of demonstrating polyspecificity. @IcahnMountSinai @jeremiahfaith1

https://t.co/8I6Z1Rrmo9

[Marcin L Pekalski @MarcinPeka]

Very fascinating ecology of IL-2.

[Journal of Experimental Medicine @JExpMed]

New research from @LabListon investigates the #cytokine network of #IL2. Using a new genetic tool, the authors show that response to IL2 depends on the cellular source. This explains old mysteries of clinical adverse events and provides new targets https://t.co/Mm8vQiakwr