Ben Perry

Drug discovery, music, mountains. Views my own.

[Medicxi @medicxi]

We’re proud to announce the launch of Alys Pharma, an immuno-dermatology focused company backed with $100m financing by @medicxi and led by world leading scientific experts dedicated to developing transformative medicines for dermatology patients worldwide https://t.co/q1Rh1HZC3d

[Ben Perry @MrBenGP]

@keefstuart 1 is (possibly) Fatal Frame / Project Zero?

[Ben Perry @MrBenGP]

@demishassabis More focus on solving actual societal problems rather than rendering the world increasingly soulless would be nice.

[Ben Perry @MrBenGP]

@juderogers

[Ben Perry @MrBenGP]

@IanDunt Lord of the Flies? 11 is just about old enough, and it’s basically the founding text for Fortnite.

[Ben Perry @MrBenGP]

@JamesParrish Congratulations buddy!

[Ben Perry @MrBenGP]

Michigan summer, 1/2 marathon training day #1 @runningpunks

[Ben Perry @MrBenGP]

@BShoichet @pwk2013 Agree that these should be considered as different issues. Speaking of which, will Aggregator Advisor ever be back online?

[ASAP Discovery @asap_discovery]

The next Antiviral Drug Discovery Open Science Forum on Dec 21 focuses on Dengue, with talks from Neelika Malavige (@GMalavige) of @DNDi and Pei-Yong Shi of @utmbhealth!

Register here to join:
https://t.co/NoRTDBrvDA

[Ben Perry @MrBenGP]

@JamesParrish That @THEBETHS album… so, so good.

[Ben Perry @MrBenGP]

@jchodera @cdsouthan @covid_moonshot @BindingDb @GuidetoPHARM @DNDi Ultimately we decided to prioritise openness up to the point that it doesn't jeopardise path to registration. As @jchodera mentioned this is still very much an experiment in progress.

[Ben Perry @MrBenGP]

@jchodera @cdsouthan @covid_moonshot @BindingDb @GuidetoPHARM This entire approach was thoroughly researched @DNDi , after many discussions with hypothetical downstream stakeholders, e.g. multinationals that would consider leading the registration and holding market authorization on an IP-free NCE.

[Ben Perry @MrBenGP]

@cdsouthan @jchodera @covid_moonshot @BindingDb @GuidetoPHARM It's a concern about well-intentioned but poorly executed experiments being run on a candidate molecule rather than scooping or willful harm. The regulatory path would still have to account for any experiments or data produced out of moonshot control.

[Ben Perry @MrBenGP]

@KRHornberger (Literally) Group. Of. Death.

[Keith Hornberger @KRHornberger]

It's here... #SynthesisSaturday special edition:

REAGENT ACRONYM BATTLE ROYALE

PLAY-IN LIGHTNING ROUND... 70 entries need to be culled to 64, so there are 6 play-in votes. Polls in the thread. Just 6 hours to vote!

Like, RT, let's go!

[Matthieu Schapira @mattschap]

CACHE challenge #3 is open for applications. Use receptor- or ligand-based approaches to predict molecules targeting the MACRO domain of SARS-CoV-2 Nsp3. We will test your compounds experimentally and release the data publicly. https://t.co/oNmbULlhUo @thesgconline @target2035

[Ben Perry @MrBenGP]

@runningpunks swag turned up! #unknowntrails of the Jura

[Ben Perry @MrBenGP]

@curiouswavefn Pi (Aranofsky)

[Ed Tate @TateScience]

Fantastic and unique long-term position for synthetic medicinal chemists interested in research supervision, #training, #education and #innovation in #medicinalchemistry and #drugdiscovery. Based in @TateScience @imperialcollege White City Campus. https://t.co/BcxX7Y1zDX

[Ben Perry @MrBenGP]

@MatToddChem @EnamineLtd @OSantibiotics @thesgconline similar to the reactivity seen for compound 12 , fig 2 on this excellent PAINS summary https://t.co/CZ9JAfN0l7

[Ben Perry @MrBenGP]

@MatToddChem @EnamineLtd @OSantibiotics @thesgconline Be careful with those molecules, pretty sure those are known nuisance compounds / PAINS via indiscreet reactivity with cysteines (diverse cysteine attack at the electrophilic CH2 adjacent to the carbonyl, with the thiotriazole as leaving group).