Leon Lagnado

We’re just biological speculation. Sitting here vibrating. We don’t know what we’re vibrating about. - George Clinton. My personal account.

[Leon Lagnado @neonsynapse]

@Neduszn8 Ray Kennedy

[Leon Lagnado @neonsynapse]

@AlasdairMSmith @waitrose What happens in Rutshire stays in Ruthshire!

[Leon Lagnado @neonsynapse]

@waitrose Re: ahistorical marketing. Tried new crisps, Steak Diane & Bloody Mary Prawn Cocktail. Quintessentially 1970s dishes yet marketed through the 1980s glam of Jilly Coopers bonkbuster "Rivals". But who saw Steak Diane at a Rutshire dinner party in the 1980s? Pas mois!

[Leon Lagnado @neonsynapse]

Lewes FC Veterans

[Max Stéph @maxstephhh]

Hey @Grok , switch Lionel Messi's jersey to the club you think he will retire with

[Leon Lagnado @neonsynapse]

At #MBL Visual Neuroscience course w/ Anna Jansson @anna_m_neuro, Angel Robles-Gomez & Leonor Afrima. Using 2P microscopy to image transfer of visual signals into & out of bipolar cells in retina of larval zebrafish. Great fun! Thanks to Directors @RichKramerLab & @SchwartzLabNU

[Leon Lagnado @neonsynapse]

@Garyfooballnut 5

[Leon Lagnado @neonsynapse]

@vblock James Beck

[Leon Lagnado @neonsynapse]

@HipsterUnionRep

[Leon Lagnado @neonsynapse]

This video doesn't do the pop-pop boat justice. Try it in your bathtub.

[Massimo @Rainmaker1973]

How a pop-pop boat works

[🎞️ Physics 4 Engineering]

[Leon Lagnado @neonsynapse]

@yaksi_emre @yesiamohyes @JosMoyaDaz1 @CurrentBiology Thanks!

[Leon Lagnado @neonsynapse]

The #retina, like other brain circuits, is under modulatory control.

@yesiamohyes and @JosMoyaDaz1 show that "Substance P and dopamine form a “push-pull” system that diurnally regulates retinal gain".

https://t.co/LYnsRmb8dR. @CurrentBiology

#zebrafish #neuroscience

👇1/

[Leon Lagnado @neonsynapse]

The actions of substance P reduce the flow of visual information, measured in bits, ∼3-fold. So while dopamine “pushes” the retina to transmit information at higher rates in the afternoon, substance P acts in antiphase to “pull down” information transmission in the morning.

😀

[Leon Lagnado @neonsynapse]

Modulation of retinal gain is accompanied by changes in patterns of vesicle release at the synapses of bipolar cells: increased gain shifts coding of stimulus strength from the rate of release events to their amplitude generated by a process of multivesicular release (MVR).

4/

[Leon Lagnado @neonsynapse]

@LewesArboretum 🙏😊

[Leon Lagnado @neonsynapse]

@IShainer @BiologyTechnion That's great. Enjoy!

[Leon Lagnado @neonsynapse]

@ZebrafishRock @yaksi_emre @iam_AhmedJ @KISNeuro @FENSorg Aah! Didnt know about alt text but do now. Thanks!

[Leon Lagnado @neonsynapse]

@ZebrafishRock @yaksi_emre @iam_AhmedJ @KISNeuro @FENSorg Love this inage. Who made it? Would they mind if I used it (with appropriate credit)?

[Leon Lagnado @neonsynapse]

Neuroscience postdoc. Flow of information controlling visually-driven behavior. Fluorescent reporters//imaging/behaviour/modelling/zebrafish. Focus on synaptic coding + factors modulating visual circuits to impact behavior.

Interested? https://t.co/wpgVtAKhRr

@ZebrafishRock