Dr. Paola Marignani

Scientist discovering something new about signalling networks, metabolic processes, scRNAseq, cancers & neuro-diseases. #MarignaniLab
Founder: @CDNWomenSTEM

[Dr. Paola Marignani @pmarignani]

Overall, LKB1 deficiency rewires breast cancer in a subtype- and cell-type-specific way, thus reshaping hormone, immune, and metabolic programs.

Read our preprint https://t.co/xs5DClUaUk

#BreastCancer #LKB1 #STK11 #scRNAseq #TNBC #ScienceIsFun #ScienceSaves

[Dr. Paola Marignani @pmarignani]

New pre-print from the https://t.co/AWI3JHMrjr!

We profiled LKB1/STK11 loss across breast cancer using 4 complementary approaches and found it does far more than flip the AMPK–mTOR switch.
A thread on what we found 🧵👇
📄 https://t.co/xs5DClUaUk

[Dr. Paola Marignani @pmarignani]

Finding 3: STK11 mutations in TNBC cluster in the kinase domain and associate with immune evasion.

Finding 4: Mammary Lkb1 deletion alone drives DCIS → invasive carcinoma with 81% penetrance, + mTOR↑, HIF1α↑, Cyclin D1↑, ER↓.
Causality confirmed in vivo. 🐭

[Dr. Paola Marignani @pmarignani]

Finding 1: LKB1 loss suppresses oestrogen, progesterone, and androgen receptor signalling.
LKB1 is not just a metabolic kinase, it actively supports hormone-responsive transcriptional programs. Losing it reshapes the hormone landscape of the tumour cell.

[Dr. Paola Marignani @pmarignani]

We combined:
🔬 CRISPR-Cas9 STK11 KO + scRNA-seq in ER+/HER2+ & TNBC cell lines
🧬 Patient tumour single-cell RNA-seq
📊 METABRIC bulk genomics (n=1,734)
🐭 Mammary-specific Lkb1^fl/fl^/WAP-Cre mouse model

[Dr. Paola Marignani @pmarignani]

@EricTopol Spectacular!

[Nathalie Grandvaux 🇨🇦 @NGrandvaux]

👇 Joignez-vous à moi demain 22 mai - 14h pour en savoir plus sur #Hantavirus. Une discussion en language accessible à tous, organisée par les réseaux @precrisa et Réseau AIRS des Fonds de Recherche du Québec - Santé.
Gratuit, mais inscription obligatoire
https://t.co/PgtsmdVDf3

[Dr. Paola Marignani @pmarignani]

@drdeannasanter @UM_Immu @umanitoba @UM_RadyFHS @DrHArmstrong @getgutsycanada @CIHR_IRSC @NSERC_CRSNG @SSHRC_CRSH @Research_MB @CHRIManitoba @InnovationCA 🎉 Congratulations

[Montse Sanchez-Cespedes Lab @CespedesMontse]

Not all mutations tell the same story. In our latest work, we distinguish pathogenic from benign variants to better predict benefit from immunotherapy in cancer treatment. https://t.co/bDWZbzepUN

[Dr. Paola Marignani @pmarignani]

@OdedRechavi Exactly. It is important that we make discoveries available to the greater scientific community, so that they can build/innovate on the work. Having discoveries spend 8-24> months undergoing reviews/revisions, serves very little other than to satisfy the reviewer's power ego.

[Dr. Paola Marignani @pmarignani]

🌞☕👩🏻‍💻 Canadian Sovereignty include Healthcare

[Avis Favaro @Avis_Favaro]

Healing Ourselves: Why Healthcare Is a True Test of Canadian Sovereignty by Eric Hoskins https://t.co/cJaDIckEqF

[Dr. Paola Marignani @pmarignani]

💨☕👩‍💻Excited to share our recent discovery. Tumour suppressors LKB1 and SMARCA4 working together to regulate gene expression, acting as a nexus between metabolism and chromatin remodelling. https://t.co/1u7asELKjE

[DalMedSchool @DalMedSchool]

From Marconi’s first wireless signal to today’s agentic AI—join us March 11 at Dalhousie for Evolution of Communication, featuring the Ambassador of Italy and leading voices in science, medicine, and artificial intelligence.

[David S. Wishart @WishartLab]

Join The Metabolomics Innovation Centre (TMIC) in a one-day symposium on the latest advancements in metabolomics, featuring 10 presentations, poster sessions and valuable networking opportunities.

Don’t miss this opportunity to connect, collaborate, and explore cutting-edge research with the metabolomics community.

Date: February 17, 2026
Location: Centennial Centre for Interdisciplinary Science (1-440) & PCL Lounge, University of Alberta

Learn more: https://t.co/boxZEQN4iV

[ɐʎɐ @ayaLAN]

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@scarcedotcity

[ɐʎɐ @ayaLAN]

Starts tomorrow on @scarcedotcity. All proceeds going to cancer research.
https://t.co/MUsyBOIZoX

Not endorsed by @MagicalTux 😇

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