The last version of our work is now out!
We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration.
https://t.co/njyyWm3oAB
Work done in @slvfre lab at @institut_curie
Online now: Conserved signals control self-organization and symmetry breaking of murine bilayered epithelia during development and regeneration https://t.co/APZkNsVdU7
Congratulations to @ChenJiang919 @yura__song and @Alessia100nze the first authors for their amazing work. A big thank to our collaborators @TheLutolfLab and Alejandro Sifrim for their precious help. https://t.co/8XLjcSRc7u
Do you want to grow 3D epithelia ex vivo long-term (~1 year) without passaging them? Check out epitheliods! https://t.co/JggRv6wRoV
Excited to have shared the journey with two great scientists @AlbertHerms and @AntoranLab and the Phil Jones' team. Image credit to @MTBejar.
It was a great pleasure to share with you these three years @JakubSumbal! A brilliant defense like the rest of your work. Wishing you all the best for your future adventures 🇩🇪
You rock 👍
Excited to share our new bioRxiv preprint: Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo.
https://t.co/kmukxrmpeA
Promising science and great discussion condensed into an intense journey! Huge thanks to @kim_bak_jensen, @martt1m, Phil Seymour at @reNEW_Global for their time, @slvfre for the support, and @EMBO for the exchange fellowship. Excited for what’s next!
Ever wondered how stem cells ensure a balance between cell fates in the gut?⚖️Turns out, they’ve got rhythm!🎶Our latest research reveals that NOTCH-driven oscillations regulate stem/progenitor cell abundance and specify secretory subtypes. Check it out: https://t.co/qvEsbAbx5O
New preprint: We have developed an integrated pipeline to i) image gastruloids in toto with dual-view 2-photon🔬, ii) quantitatify cell and tissue-scale patterns of gene expression and morphometric features, iii) interact with the data in @napari_imaging. https://t.co/NvexmiWnHY
⏰ Last days to register to the Developmental Biology international course at @institut_curie! Discover full program, proposed in 2 versions long/short, and dive into a comprehensive coverage of the paradigms of modern Developmental Biology.
➡️ https://t.co/U1SlkFsZxQ
Happy to see enthusiasm for our work! 🎊
Last part of our communication:
#YAP, #Notch and #p63 regulate the self-organization of 4 different bilayer epithelia.
💭But, what did we learn conceptually? 💭
https://t.co/aqGAsPHMaz
Work by @slvfre team at @institut_curie
I would like to thank all the @slvfre team, particularly my bench mate @JakubSumbal for the great discussions, but also @EdouardHannezo, @bellaiche_y and Prof. Michel Labouesse for their advice as member of my PhD committee.