Silas E Busch

Postdoc @Rockefeller University, UChicago PhD Works on: Dendrites, mouse cerebellum, fly learning+memory Dabbles in: Philosophy, writing, poetry, plants

[Silas E Busch @SI_plasticity]

New in @ScienceMagazine
In mice, we explore a non-canonical circuit in a sub-population of cerebellar Purkinje cells with dendrite structure motifs that are nearly universal in humans

https://t.co/qrOHRds7nU

#ScienceResearch 🔬🐭🧠🧑‍🦱@UChicago_Brains @UChicagoBSD @UChicago
🧵⬇️

[Silas E Busch @SI_plasticity]

Huge thanks goes to my mentor Christian Hansel, the UChicago neuro institute @UChicago_Brains, and to many for their ideas and feedback along the way: @TingFengLin1, Abby Silbaugh, @auroraferrell_ , Donald Huang, @EatockLab, Wei Wei, @Sheffield_Lab, @neuroMOOC

[Silas E Busch @SI_plasticity]

Inspired by Cajal, the Hansel lab's new work in @eLife provides a comparative histological analysis of human and mouse Purkinje cell morphology. Following our 2023 study, we detail differences of scale and kind between the neurons of the two species 🧵👇
https://t.co/8wp7g6Ds3a

[Silas E Busch @SI_plasticity]

Purkinje cells of similar morphologies also tended to cluster near each other. If morphology dictates some features of PC function, then this cell-cell clustering may generate patches of functional similarity in the cortex

[Silas E Busch @SI_plasticity]

I was very excited to speak at the @wusmsl journal club. Great community ! Got some really interesting questions and insights from within and outside the cerebellar field! Check out the recording here

[Andrew Pruszynski @andpru]

See our first @wusmsl journal club of the academic year! We hosted @SI_plasticity, who told us about this fascinating work, recently published in Science, showing the innervation of purkinje dendrites by multiple climbing fibers. https://t.co/5umUFujk3r

[Silas E Busch @SI_plasticity]

@AmandaLeBel3 Thanks! As you’ll see, some of the analysis and discussion is inspired by your insightful (functional!) work in human 😁

[Silas E Busch @SI_plasticity]

Human neurons are incredibly complex and Purkinje cells are, by far, the largest in our brain. We give a detailed characterization of their dendrite and spine morphology and distribution across cerebellar regions compared with mouse. Check it out!

[bioRxiv Neuroscience @biorxiv_neursci]

Non-allometric expansion and enhanced compartmentalization of Purkinje cell dendrites in the human cerebellum https://t.co/zZbEQZRmo2 #biorxiv_neursci

[Silas E Busch @SI_plasticity]

@carobellum What’s more, parts of this would absolutely not exist if not for your studies!! I’m so grateful for your work and insight!

[Silas E Busch @SI_plasticity]

@neurodevKathy @aniladmello Thank you! Do let me know if you have thoughts you’d like to share; I’d love to get your perspective on it!

[Silas E Busch @SI_plasticity]

@carobellum @UniofOxford @wellcometrust @MKFlugge Incredible news! Congratulations Caro!! I’m glad they recognized how awesome you are!! 🤩🥳

[Silas E Busch @SI_plasticity]

@HeatherDSnell I’m dying 🤣

[Silas E Busch @SI_plasticity]

@thejenjay Oh sweet! Nice way to spread out the thesis writing process. Best of luck!!

[Silas E Busch @SI_plasticity]

@thejenjay Incredible (scientifically and artistically)!!

[Silas E Busch @SI_plasticity]

@neurodevKathy Thank you!

[Silas E Busch @SI_plasticity]

Check out this wonderful write-up by #NIH Director's Blog on my image and our recent work in mouse and human cerebellum!

[NIH @NIH]

Learn how this winning image in the NIH #BRAINInitiative’s annual photo/video contest is changing conventional wisdom on #brain anatomy. Details on the #NIH Director’s Blog. #studyBRAIN https://t.co/3NZVxpWCwa

[Silas E Busch @SI_plasticity]

The photo is now part of the 2024 BRAIN Initiative calendar, which you may have picked up from the #NINDS booth at SfN or can order.
https://t.co/4lukv2gFed

[Silas E Busch @SI_plasticity]

The #NIH Director's Blog wrote an awesome piece about my submission to the @USBrainAlliance photo contest and how it encapsulates my recent work comparing mouse and human cerebellar anatomy. #studyBRAIN
https://t.co/nU7vbHEDyE