Stefan Mereiter

Principal Investigator @ Medical University of Vienna | Research at the interface of glycobiology and breast & gynecological cancers

[Stefan Mereiter @SMereiter]

So thrilled to receive this grant, which allows me to push my #glycotime projects forward! Rolling up my sleeves and getting to work – there is still so much to be uncovered. Huge shout-out 🙏 to my brilliant & kind reviewers, wherever you are, and to @FWF_at for funding! ♦️

[IMBA imbavienna.bsky.social @IMBA_Vienna]

Stefan Mereiter, postdoc and member of the @penningerlab, was awarded the ESPRIT grant for the next three years. In this time, he will continue his research on glycosylation interference in breast cancer. We wish him success. @FWF_at @SMereiter #CancerResearch

[Stefan Mereiter @SMereiter]

how it feels to publish a paper these days

[Stefan Mereiter @SMereiter]

Overall, removing sialylation from mammary epithelium was well tolerated, yet it rendered breast cancer cells vulnerable to immunotherapy.

A compelling therapeutic window and a strong rationale for targeting tumor hypersialylation in breast cancer.

[Stefan Mereiter @SMereiter]

🚨 Our newest manuscript is out in Nature Communications:
Hypersialylation in breast cancer immunoregulation: uncovering novel mechanisms and highlighting major therapeutic potential.
+6 years in the making.
Dive into: https://t.co/dssVRe3ZGV

[Stefan Mereiter @SMereiter]

6. In the autochthonous MPA/DMBA model, a model of luminal B breast cancer, removing sialylation from the equation broke the cancer's hardwired resistance to immunotherapy.
To our knowledge, that's unprecedented in this model.

[Stefan Mereiter @SMereiter]

Setting up my new lab. Exciting times! 🧪🔬

[Stefan Mereiter @SMereiter]

🚨 PhD position open! 🚨
Join our team at the Medical University of Vienna to study glycan regulation in mammary organoids, milk, and breast cancer.
Details in the image – please share! 🧬✨

[Stefan Mereiter @SMereiter]

Feeling honored to work in a lab with two (!) of 2024’s most cited scientists: mentor Josef Penninger🧠and lab colleague Max Kellner 📚 (@clarivate). Max (spot him sitting behind me in yesterday’s lab meeting) is a PhD student 🤯 @penningerlab

[The Knoblich Lab @Knoblich_lab]

Excited to share our latest preprint (@biorxivpreprint) on brain organoid development. Lead by Julia Naas and Meritxell Balmaña (@txellbalmana) with Arndt von Haeseler, Christopher Esk (@christopher_esk) and colleagues across Vienna. @MaxPerutzLabs, @IMBA_Vienna, @CeMM_News.

[MedUni Wien @MedUni_Wien]

A team from @BOKUvienna, #MedUniVienna & @IMBA_Vienna presented a scalable method that provides insights into #glycobiology. The aim was to investigate structural differences in glycan chains in various organs & to determine their extent. ➡ https://t.co/JXMIAE8UQF

@NatureComms

[Stefan Mereiter @SMereiter]

@mryanshi @NatureComms @penningerlab @dynamic_epitope Yes, very impressive study from @dynamic_epitope which we cite and highlight in our introduction. Our work - using PGC-LC- is a complement to it and adds an important degree of structural information to the mouse N-glycome! For more info delve into our📖

[Stefan Mereiter @SMereiter]

@chrashwood @BOKUvienna @IMBA_Vienna @MedUni_Wien @UMich @JohStadlmann Many thanks!
1 We were surprised too! Wouldn’t have looked for it if it wasn’t for the described approach. Good agreement with literature & organs affected by MHV gave confidence.
2 During paper prep we colored it gray for no reason and didn’t recall changing it to blue later.

[Stefan Mereiter @SMereiter]

1/
Did you know? Glycans—complex sugar structures—decorate almost every protein processed by the ER/Golgi. These N-glycans coat our cells, playing critical roles in cell interactions and immune processes. 🍬

Curious about how they vary?

Let’s dive in!