Leslie Sombers

Prof of Pharmacodynamics at U. Developing independent thinkers, building electrochem tools for monitoring molecules in the brain, and discovering new things

[Leslie Sombers @SombersLab]

#crushingit in Gainesville!!! The UF lab is renovated and ready, students have safely made the trip, and @JovicaTodorov1 's enkephalin paper is featured as a cover for Analytical Chemistry! Artwork credit goes to our own @OneMetricDylan .

[Leslie Sombers @SombersLab]

@nanopharmNC Same. You’re not alone. I haven’t spoken to either parent because my mother supports my father in his abuse and I’m a sinner for not ‘honoring my father’.

[Leslie Sombers @SombersLab]

Gracey McNair representing the NC contingent of the lab at the NCSU Chem undergraduate research poster sesh. Inspiring young minds !! 💪👍 Go Gracie!!

[Leslie Sombers @SombersLab]

@RossLabUC I usually just don’t attend if it’s after 3:30. I simply can’t make it

[Leslie Sombers @SombersLab]

Congratulations to Greg McCarty, Carl Meunier and the whole team!!! #cantstopwontstop, #electrochemists, #somuchpotential 👏💪

[Leslie Sombers @SombersLab]

#CRUSHINGIT at UF with another new paper out in ACS Sensors! We electrodeposited polymer films on the electrode that allow for the tunable, size-based exclusion of larger molecules.

https://t.co/77NW7GKgVR

[Leslie Sombers @SombersLab]

When using electrochemical detection strategies in live tissue, we are always worried about selectivity. Here, dioxythiophene monomers were mixed with Nafion and used to create a membrane with nanostructured pores of increasing size.

[Leslie Sombers @SombersLab]

The modified electrodes exhibited enhanced selectivity for smaller peptide species over larger peptides in a manner consistent with the size of the dioxythiophene monomer incorporated into the polymeric film, allowing for tunability in terms of size-based selective detection.

[Leslie Sombers @SombersLab]

The modified electrodes were characterized in the voltammetric detection of dopamine and a series of tyrosine containing neuropeptides of increasing size: met-enkephalin (M-ENK), oxytocin (OXY), neurotensin (NT), and neuropeptide Y (NPY).

[Leslie Sombers @SombersLab]

Thank you @Kalynn_mckenzie, @OneMetricDylan and the whole team for this awesome graphic!! You rock!

[Matthew Dominick @dominickmatthew]

Timelapse flying by Hurricane Milton about 2 hours ago.

1/6400 sec exposure, 14mm, ISO 500, 0.5 sec interval, 30fps

[Leslie Sombers @SombersLab]

This week was national postdoc appreciation week and we want to give a shoutout to our awesome postdoc, @JovicaTodorov1! Jovica studied voltammetry as a grad student at NCSU, and as a postdoc at UF he is learning electrochemical impedance spectroscopy 💪 #somuchpotential

[Leslie Sombers @SombersLab]

UF academic year kickoff - here's to new beginnings! Wish @JennaBerger4 was here too! 🧡

[Leslie Sombers @SombersLab]

THIS! This is the Sombers Lab!! These are the amazing people who have done the work since we began at NCSU in 2008, through the present at UF. Training these researchers is my most significant contribution to science and I am so proud. Go Team!!!

[Leslie Sombers @SombersLab]

@G_A_Rabah @JovicaTodorov1 @OneMetricDylan Thx Ghada!

[Leslie Sombers @SombersLab]

#crushingit in Gainesville!!! The UF lab is renovated and ready, students have safely made the trip, and @JovicaTodorov1 's enkephalin paper is featured as a cover for Analytical Chemistry! Artwork credit goes to our own @OneMetricDylan .

[Leslie Sombers @SombersLab]

See the paper here!👇 @ACS4Authors #MyACSCover
https://t.co/MY3eUwb4b6

[Leslie Sombers @SombersLab]

A factory is used to represent synthesis of custom peptides cleaved from pro-enkephalin. The illustration shows a team of scientists seeking to understand detection of these peptides using electroanalytical signatures dictated by chemical structure.

[Leslie Sombers @SombersLab]

@Vero_Augustyn Congratulations to Matthew!! Great defense talk - I love the cv work!!

[Leslie Sombers @SombersLab]

Jovica Todorov is crushing it!!!! #cantstopwontstop!!!! DM us if you'd like to see the whole article 💪

[Leslie Sombers @SombersLab]

New paper out - this one is🔥!! Congratulations to Dr. @JovicaTodorov1 and the whole team ! https://t.co/MY3eUwb4b6

[Leslie Sombers @SombersLab]

Overall, this study demonstrates how fast-scan cyclic voltammetry can be utilized to discriminate between peptides with small differences in the chemical structure, thus establishing a framework for reliable quantification of small peptides in a complex signal, broadly speaking.