Ryan Clark

[BowTied Biohacker @BowTiedUM]

12 Years of Peptide Research and Insane Self-Experimentation Boiled Down to a 2-Minute Cheat Sheet:

BPC-157 Oral

- Mood stabilization, cognition, anti-addiction, gut health, skin quality, 🍆 size & hardness, minor injuries & pain, hair growth w/ micro needling
- Partial sequence of the body protection compound (BPC) isolated from the human gastric juice

BPC-157 Injectable

- Healing major injuries, chronic pain, weaker but still notable gut & cognitive benefits, mega 🍆 gains, excellent hair growth w/ micro needling
- Partial sequence of the body protection compound (BPC) isolated from the human gastric juice

TB-500 / TB4

- Powerful anti-inflammatory + rapid wound healing
- Produced endogenously (Thymosin Beta 4)
- Synergizes well with BPC

KPV
- Powerful anti-inflammatory, especially for gut when taken orally
- Derivative of a-MSH which you get for free from the sun.

PT-141
- Another a-MSH derivative 🌞
- Men: increased size and hardness, spontaneous b0ners, takes 2-6 hours to kick in, full caveman-smash mode. lasts a full day, residual effects for another 1-2 days
- Females: FDA approved for female sexual dysfunction. Induces nymphomania.

Melanotan I

- Yet another a-MSH derivative 🌞
- Extremely useful, one of my favorites if not my favorite
- Increases melanin production: yes that means faster tans but also enhances energy production, less inflammation, and better mood, cognition, and libido

Retatrutide
- Anabolic Ozempic without the Nausea
- 6 Pack on EZ mode
- Best fat loss peptide I've tried by far, and I've tried them all
- Should MICROdose IMO at .5 to 1mg per week, less is more
- Enhanced mood, cognition, energy, muscle fullness, and fat loss while appetite and all cravings, not just food, are suppressed

GHK-Cu

- Ultimate anti-aging, cosmetic enhancement, wound healing, collagen & elastin synthesis promoter

Thymosin Alpha 1

- Hardcore immune system enhancement
- Fight off infections more effectively
- Reduces autoimmune activity

Thymalin
- Immunomodulatory and anti-inflammatory peptide
- Studies show a significant concentration of C-reactive protein, IL-6, D-dimer, and lactate dehydrogenase in the blood
- have not personally tried

NA Semax
- Enhanced, mood, focus, motivation, mental clarity, learning, recollection, problem-solving, and LIBIDO
- Derivative of the adrenal peptide ACTH

Adamax
- NA Semax on steroids
- Adamantane group added for increased blood-brain-barrier absorption and half-life

NA Selank
- Anxiolytic peptide that enhances, verbal acuity, mental clarity, learning & memory
- Derivative of the endogenous immunomodulatory peptide Tuftsin

CJC & Ipamorelin

- Increases HGH & igf-1
- Equivalent to about ~1.5iu pharmaceutical hgh if ran high enough

Tesamorelin

- Most potent HGH secretagogue
- Equivalent to 2iu+ pharmaceutical hgh

[BowTied Biohacker @BowTiedUM]

The sun is nature's Ozempic, Retatrutide, Adderall, Morphine, Antibiotic, Anti-Inflammatory, and pretty much every pharmaceutical drug you could need

Here's a breakdown of each wavelength of interest to biohackers, and why Big Pharma has to rig the science so you think the sun is harmful:

UVB (280–315 nm)

Peptide factory + Vitamin D

UVA (315 nm to 400 nm)

Neurotransmitter factory, Nitric Oxide, Opsin regeneration

All UV = 5AR/DHT Upregulation, POMC Activation

405nm Violet

Antimicrobial, Microbiome reset

485nm Cyan

Circadian signal/Wakefulness + Drive/Melanopsin activation

630nm Red

Surface repair, CCO activation, collagen synthesis

670nm Deep Red

Mitochondrial boost, Peak CCO absorption, subcellular melatonin

760nm NIR

Transition depth, Opsin regeneration, deeper tissue engagement

810nm NIR

The Brain wavelength, Transcranial PBM, cerebral blood flow

850nm NIR

Deep tissue Joint/muscle/bone, water chromophore

935nm NIR

Extended depth, Water layer interaction, organ support

1050nm NIR

Heat-gated channels, lymphatic support

The POMC Cascade - This Is Where the Real Magic Happens:

UVB light stimulates the POMC gene in your skin AND in your brain (specifically the arcuate nucleus of the hypothalamus).

α-MSH (Alpha-Melanocyte Stimulating Hormone) - Creates melanin (your solar panel semiconductor), suppresses appetite through MC4R receptors in the brain, increases energy expenditure, has potent antimicrobial and antifungal activity, modulates immunity, influences eNOS/nitric oxide, and regulates cholesterol/bile acid metabolism. Low α-MSH = obesity, metabolic syndrome, immune dysfunction, poor skin pigmentation. This is the anorexigenic peptide - it decreases food desire in the brain

β-Endorphin - Your endogenous opioid. A landmark 2014 Cell paper proved that UV exposure causes p53-mediated POMC transcription in keratinocytes, producing β-endorphin that enters systemic circulation and activates mu-opioid receptors. They showed that chronic UV exposure produced opioid tolerance and that blocking opioid receptors caused measurable withdrawal symptoms. Nature addicted you to sunlight on purpose. As someone who spent a decade on exogenous opioids, I can tell you - nothing replaces the feeling of genuine endogenous β-endorphin production from UV exposure. The mechanism matters.

ACTH - Stimulates cortisol production (gluconeogenic - makes glucose from sunlight)

CLIP - Insulin secretagogue (raises insulin without food intake)

β-MSH - Controls B cells (humoral immunity)

γ-MSH - Controls T cells (cellular immunity) - this is why skin breakouts often indicate problems with beta/gamma MSH processing

When you expose your skin to UVB, you're activating an entire neuroendocrine cascade that:

Lowers leptin by improving leptin sensitivity through the melanocortin pathway.

Leptin resides in subcutaneous fat and its activation is directly controlled by light on skin and eyes. When this pathway works correctly, you get appropriate satiety signaling.

Increases GLP-1 signaling in the brain - the same pathway that drugs like semaglutide (Ozempic) artificially activate. UV exposure does it physiologically. Think about that.

Produces antimicrobial peptides - NB-UVB has been shown to alter antimicrobial peptide expression in the skin, enhancing your innate immune defense

Stimulates serotonin production - UVB stimulates serotonin in keratinocytes while inhibiting dopamine production locally, allowing serotonin accumulation

Generates beta-endorphin systemically - not just locally in the skin, but at levels that cross into plasma and affect the entire body

Upregulates melanogenesis - building melanin, your body's semiconductor solar panel that converts light energy into DC electrical current

[BowTied Biohacker @BowTiedUM]

Epstein knew the pineal gland makes a lot more than DMT

Harmine, Harmaline, Harmane (& Pinoline)

SAME ALKALOIDS AS AYAHUASCA

IN YOUR BRAIN

Every ancient tradition knew this

The Eye of Horus is anatomically mapped to a sagittal cross-section of the brain with the pineal at center

The pinecone symbolism in the Vatican, in Sumerian art, in Hindu iconography

The "pine" in pineal literally means pinecone

They were telling us what this organ does for thousands of years, & we calcified it with municipal water additives & called it a "vestigial organ"

The gland contains piezoelectric microcrystals

That means they generate an electrical charge in response to mechanical pressure (and vice versa)

This is the same property that makes quartz watches work, the same property that makes certain transducers function

Every ancient tradition on the planet identified this as the "third eye" / the seat of higher consciousness

Modern quantum biology is finally catching up

You have a piezoelectric consciousness antenna sitting in the geometric center of your skull

Let that sink in for a second

These crystals detect and transduce electromagnetic fields and act as an interface for consciousness to interact with biological material

You could even look it as "the motherboard of the soul"

Nobody's talking about this, but you can connect the dots and verify EVERYTHING

But, wait THERE'S MORE

While N, N-DMT and Harmala Alkaloids are known to produce the Ayahuasca Experience, AKA a Guided tour to the spirit realms, the pineal has also been found to produce 5-MeO-DMT

Also known as "The God Molecule"

Though this is never talked about

5-MeO is called the "God Molecule" because it produces an experience that is typically described as Omnipresence

"Being in every place, at every time in the past present and future- All At Once"

A conscious experience of exactly what physics models make the 7th dimension out to be

It's what mystics and monks refer to as "Unity Consciousness"

The entrance to the spirit world and encounters with "guides" followed by unity consciousness is EXACTLY the same phenomenon reported by survivors of Near Death Experiences (NDEs)

Here's where it gets ugly

The modern human pineal gland looks like a calcified pebble on brain scans by age 17 in most Western populations

In traditional cultures with clean water and natural light cycles? Minimal calcification even into old age

From a service-to-self orientation, you want two things simultaneously:

First, you want to DEGRADE the antenna in the general population.

Fluoride calcification, artificial light destroying melatonin cycles, EMF bombardment disrupting the piezoelectric signaling

A population with bricked pineal glands can't access higher density awareness.

They're trapped in pure 3rd density materialist consciousness

Reactive, fearful, easily manipulated, disconnected from intuition and inner knowing

This is the mass control mechanism happening in front of your very eyes (YES THIS SCREEN, U.S. patent US6506148B2, titled Nervous System Manipulation by Electromagnetic Fields from Monitors) through:

-Municipal water fluoridation
-Ubiquitous blue light
-A lack of UV and Red Light (less melatonin substrate + Tryptophan absorbs UV)
-Extreme nnEMF exposure

The elite interest in consciousness manipulation is historically documented through MK-Ultra, ARTICHOKE, and related programs

Second, you want to CONCENTRATE and HARVEST the biochemical outputs for your own use or experimentation

If HIOMT and related methyltransferases can generate novel tryptamine compounds from melatonin, then controlling the supply of those enzymes gives you the ability to manufacture keys to perception that the general population doesn't even know exist.

Penguin pineal glands are rich in this enzymatic machinery because of their extreme light/dark cycles

The Vedic rishis described prana.

We call it biophoton emission and mitochondrial electron transport.

The Taoists mapped meridians.

We're now measuring them as fascial conductance pathways.

The Egyptians encoded the pineal as the Eye of Horus.

We finally figured out it contains piezoelectric crystals and Psychedelic biosynthetic enzymes.

Every single time, the mystical framework was there first, and science shows up centuries later going "oh wow, we discovered something

In our own experience (and across hundreds of followers), when you start addressing pineal health, people report changes that go way beyond better sleep:

-Vivid dreams come back
-Intuition sharpens
-Creativity unlocks
-Emotional processing deepens

It's like life going from a Super Nintendo game to an 8k hyper-immersive VR with all the cheatcodes on and levels maxxed

The decalcification protocol

1) Eliminate the inputs:

Fluoride-free water (reverse osmosis or spring), fluoride-free toothpaste, organic food to reduce glyphosate exposure. 100% ZERO TOLERANCE for fluoride. This is non-negotiable.

2) Restore the cofactors

Magnesium saturation + additional Acetyl Taurate for the brain, Iodine and DHA from fresh seafood, boron, vitamin K2 MK-7 (100-200mcg to redirect calcium out of soft tissue)

3) Optimize light environment and avoid nnEMF

Sunrise viewing every morning, 30-60 minutes minimum. Mid day sun. Sunset viewing.

COMPLETE darkness during sleep

Blue light elimination after sundown

Your pineal gland needs the correct light signals to produce melatonin at the right time and in the right amounts

4) Bioregulators (Essential)

Epitalon: the actual pineal gland peptide

Pinealon: ironically just a general brain-mitochondria function peptide that's

5) Targeted support

Shilajit (contains fulvic acid which crosses the blood-brain barrier and helps chelate heavy metals),

Raw cacao (theobromine stimulates pineal function)

Chaga mushroom (melanin content supports pineal melanogenesis)

Tamarind fruit has actual research showing it increases fluoride excretion through urine

6) Redacted, but discussed on substack (link in bio/below)

Start low and slow with everything.

If your body has been accumulating halides (fluoride, bromide, chlorine) for decades, mobilizing them too fast will make you feel like garbage

References:

Key studies on trace harmine/harmaline/harmane in human brain hidden in plain sight via precursors & pathways

"Pharmacological and therapeutic effects of Peganum harmala..." Moloudizargari et al. (2013) PMC3841998

"Dynamic Changes of Endogenic or Exogenic β-Carboline" Cao et al. (2022) PMC8794950

"β-Carboline alkaloids in Peganum harmala and inhibition..." Herraiz (2010) DOI:10.1016/j.fct.2009.12.002

"Effects of psychedelics on neurogenesis..." da Cruz et al. (2023) bioRxiv:2023.07.19.549676

"Neurobiological Research: DMT and MAO Inhibition" Egger et al. (2024) DOI:10.1007/s00018-024-05353-6

"Role of Plant Derived Alkaloids..." Hussain et al. (2018) DOI:10.7150/ijbs.20802

"Cerebroprotective effect of isolated harmine..." Biradar et al. (2013) PMID:24506035

"Effects and mechanisms of harmine on ameliorating..." Xie et al. (2025) DOI:10.1016/j.jep.2024.118616

"Harmine stimulates proliferation..." Dakic et al. (2016) PMC5144684

More on endogenous β-carbolines in mammals/humans.

"The alkaloids of Banisteriopsis caapi..." Morales-García et al. (2017) DOI:10.1038/s41598-017-05407-9

"Ayahuasca as a Decoction..." Nižnanský et al. (2022) DOI:10.3390/jcm11041147

"Alkaloids of Peganum harmala L...." (2021) DOI:10.3889/oamjms.2021.6654

Studies confirming trace 5-MeO-DMT in pineal/brain - biosynthesis via INMT/ASMT

"Implications of Indolethylamine N-Methyltransferase (INMT) in Health and Disease..."
(2025) PMCID: PMC12467775  PMID: 41008295

Shen et al. 2010 – Detection of 5‑MeO‑DMT in human blood/urine/CSF

"N,N-dimethyltryptamine and the pineal gland..." Nichols (2018) DOI:10.1177/0269881117736919

"N,N-Dimethyltryptamine (DMT), an Endogenous..." Barker (2018) DOI:10.3389/fnins.2018.00536

"The clinical pharmacology... of 5-MeO-DMT" Reckweg et al. (2022) DOI:10.1111/jnc.15587

"5-methoxy-N,N-dimethyltryptamine: An ego-dissolving..." (2019) bioRxiv:578435

"Why N,N-dimethyltryptamine matters..." Chaves et al. (2024) PMC11576444

"'Mystical' Psychedelic Compound..." Michigan Medicine (2019)

"Psychedelics promote neuroplasticity..." Vargas et al. (2023) DOI:10.1126/science.adf0435

"Dark Classics in Chemical Neuroscience: DMT" (2018) DOI:10.1021/acschemneuro.8b00101

[Women Being Awful @WomenBeingAwful]

Feminism is the biggest scam in the world

[BowTied Biohacker @BowTiedUM]

Testosterone is power and drive

DHT adds direction, calm, calculated, resilience

E2 protects, regenerates, sustains, and lets you feel something

Balance is key

Convert your lab values to ng/dl

(Test+DHT)/E2 > 350, < 500

While Test:DHT < 10:1

And E2 2.5ng/dl or greater

[Caitlin Johnstone @caitoz]

People like me take great pains to avoid coming across as antisemitic in our criticisms of Israel, and then Jewish Zionists go to these events all “Yes we Jews need to be actively manipulating western institutions in order to deceive everyone and control society.”

[Abud Bakri MD @AbudBakri]

This is why I am concerned about using a 5 alpha reductase inhibitor like finasteride

Yes, DHT is a powerful androgen

But more importantly, it is converted in metabolites in the brain, neurosteroids like 3α-Androstanediol that are anti-anxiety and important for mental health

hypothesis: low DHT levels are a contributor for male mental health issues, independently from low T, especially when the ratio of T/DHT is off

[Dr. Insensitive Jerk @DrInsensitive]

Now that India has flooded the world with FFMGs (Fake Foreign Medical Grads) we must rely on other means to exclude impostor doctors.

The US has two main defenses against impostors:

1. US doctors must complete a supervised US residency. Unfortunately, this residency requirement has been eliminated in 19 states, including mine.

2. Our second and final safeguard is the licensing exam. Almost all US doctors must eventually pass the three parts of the USMLE (US Medical Licensing Exam.)

Unfortunately, exam fraud is as simple as hiring a ringer to take the test for you (he needs to look vaguely like the picture on your driver's license) and avoiding the test centers that check fingerprints. (Grok summary attached.)

Or, impostors could obtain the questions in advance, from insiders or from earlier test takers.

If this sounds like a conspiracy theory, well, it already happened, and you will never guess where.

In 2024, hundreds of scores were invalidated due to leaked questions in Nepal (an Indian suburb) and to anomalous high scores at international centers in India, Pakistan, Nepal, and Jordan.

The statistically-unlikely scores were eventually blamed on early exam takers sharing the questions in WhatsApp groups.

In other news, you can take the first 2 parts of the US medical licensing exam in India. Then you can start practicing medicine in the USA.

Your Indian doctor might be a resident who purchased his Indian medical diploma then purchased the US licensing exam questions and took the test in India.

Fortunately, Part 3 of the exam, which must be passed at some point during residency, can only be taken inside the USA. So we can breathe easy, right?

Well, not exactly.

The US medical licensing exam is written and scored by two organizations. The first is the FSMB (Federation of State Medical Boards) whose president and CEO is....

wait for it....

Dr. Humayun Chaudhry.

The other organization that writes and scores the US medical licensing exam is the NBME (National Board of Medical Examiners.) NBME's Chairman of the Board is....

wait for it...

Dr. Reena Karani. That's her picture below, and why yes, she does happen to be Indian.

The physical testing centers are managed by a company called Prometric, whose Chief Products and Technology officer is....

wait for it....

Jay Chakrapani

Are you seeing the problem with our safeguards against fake doctors?

https://t.co/C3Eh2btRss

[Elon Musk @elonmusk]

Interesting

[Hans Amato @HansAmato]

Myrrh might be the most potent natural aromatase inhibitor on the planet.

Which is why I'm testing the CO2 myrrh extract from Nootropics depot next. 3 caps a day. Results in 2 weeks.

[MAZE @mazemoore]

This is one of the more important videos I’ve made.

Never forget this evil.

[Woz @accordingtowoz]

Looks like someone was a little giddy and accidentally let the cat out of the bag...not surprisingly AIPAC ended up deleteting this post...

[gaezv @gaezpeat]

Prolactin Lowering Tools

- Lisuride, Terguride, Metergoline
- Bromantane
- Gingko Biloba
- Vit E, Aspirin,
- LD. T.Progesterone
- LD. DHT
- LD. Exesmestane
- HD. Salt
- P5P, Zinc, T3, Sun, Calcium, Sugar, Apigenin, RJ, ttfd
- LD. Rasagiline
- 9mebc, modafinil, prl 8 53, mucuna

[Georgi D. @haidut]

Prolactin receptor antagonist cures baldness and reverses hair graying [https://t.co/1kpwWg3ADL] #ABS-201 #balding #baldness #estrogen #graying #hair #prolactin #stress #raypeat #idealabs #idealabsdc

[Jamal Dinkoui @BerbarianWizard]

🧵 Most POTENT ways I’ve boosted DHT (PERSONAL EXPERIENCE) – ranked 🔥

What worked like magic ⚡ What was meh 😐 What flopped 👎
Let’s go 🧠💪

[Parody Jeff @Parodyjeffx]

Israeli diplomat brags about turning European cities into criminal ghettos by flooding them with Black immigrants.

They don’t even hide it anymore.

[🅰️SIADecoded @asia_decode2]

🇮🇳Father of the Year :

A Hindu man married his own daughter and said, "The person who plants a plant has the first right to have the fruit. Likewise, I have brought her on earth and I must have full right at first to enjoy with her."

When the interviewer asked him, "Have you done everything with her?" the man replied, "What's wrong in that? It's normal in our Hindu culture and it's the only justice."

How pathetic, savage and subhuman demon are these people!

[🇨🇭🏴󠁧󠁢󠁥󠁮󠁧󠁿InLucysHead🏴󠁧󠁢󠁥󠁮󠁧󠁿🇨🇭© @InsideLucysHead]

You better believe it...

1. IN the 1400s, a law was set forth in England that a man was allowed to beat his wife with a stick no thicker than his thumb, hence we have 'The rule of thumb'.

2. Many years ago, in Scotland, a new game was invented. It was ruled 'Gentlemen Only, Ladies Forbidden', and thus the word GOLF entered the English language.

3 Each King in a deck of playing cards, represents a great 'King' in history;

Spades - King David

Hearts, Charlemagne

Clubs, Alexander the Great

Diamonds, Julius Caesar

4. In Shakespeare's time, mattresses were secured on bedframes by ropes. When you pulled on the ropes the mattress support tightened, making the bed firmer to sleep on, hence, the phrase 'Goodnight, sleep tight'.

5. It was accepted practice in Babylon 4000 years ago that for a month after the wedding, the bride's father would supply his son in law with all the mead he could drink. Mead is a honey beer, and because their calendar was lunar based, this period was called the 'Honey month', which we know of today as the 'Honeymoon'.

6. Since 1966, English fans have said they are going to win the cup at the start of every football competition, hence the phrase, 'Deluded twats'.

[Jesse Morse, M.D. @DrJesseMorse]

I practice what I preach.

Here is the current peptide stack I’m currently on for health optimization, cutting, energy optimization and healing:

Monday

Reta - 1 mg AM
NAD+ - 25 mg AM
CJC/Ipa (no DAC) - 250 mcg QPM
GHK-Cu / BPC-157 / TB-500 - 1.5 mg / 500 mcg / 500 mcg AM

Tuesday

Thymosin Alpha 1 - 1.5 mg AM
CJC/Ipa (no DAC) - 250 mcg QPM

Wednesday

NAD+ - 25 mg AM
CJC/Ipa (no DAC) - 250 mcg QPM
GHK-Cu / BPC-157 / TB-500 - 1.5 mg / 500 mcg / 500 mcg AM

Thursday

Reta - 1 mg AM
CJC/Ipa (no DAC) - 250 mcg QPM

Friday

NAD+ - 25 mg AM
CJC/Ipa (no DAC) - 250 mcg QPM
GHK-Cu / BPC-157 / TB-500 - 1.5 mg / 500 mcg / 500 mcg AM

I recently completed my annual cycles of Epithalon (sleep), and mitochondrial rejuvenation (MOTS-c, SS-31).

Up next anti-aging: FOXO4-DRI

Mind you this is only the injectables, I have about 30-40 oral supplements that I take daily to complement the injectables.

THIS IS NOT MEDICAL ADVICE. THIS IS ME BEING TRANSPARENT.

[9th Life @_9th_Life_]

Okay, update so far. I went through this whole list and manually compiled all the responses. I will do another update tomorrow.

Spreadsheet attached.

Positive mentions:

1. Peptide Supply Co : 9 (@PeptideSupplyCo)
2. Elite Research: 8 (@freedooksX)
3. Peptide Partners: 6 (@PeptidePartners)
4. Crush Research: 6 (@rorynotsorry)
5. Peptide Plugs: 3 (@PeptidePlugs, @tonymission)
5. Kimera Chems: 3 (@KimeraChems)
6. Peptide Crafters: 2, Lab Rats: 2, Skye Peptides: 2, Peptira: 2, Aavant Research: 2, Apex: 2, Premier Bio Labs: 2, NG Peptides: 2, OmegAmino: 2, Wolverine: 2, Orbitrex: 2, Disclosed Labs: 2

Negative:

- Peptaura: 2, Vida Labz: 1, Nura Peptide: 1, Barn: 1, Bluewell Peptides: 1, Kits4less: 1, Vandl: 1, Iron Peptides: 1, Swiss Chems: 1, Onyx Research: 1, Apex (negative): 1

Disclaimer: This information is for educational and research purposes only.