Sun | ia

General Surgery PGY1
Artist at night ✨ age 25+ ♀ NYC

[Sun | ia @SunKefi]

@fuqekgs My attending’s office is filled with very expensive Lego sets!

[Nicholas Hornstein @GIMedOnc]

#ASCO26

This one is special.

This is the hottest paper of 2026 and potentially in the history of pancreatic cancer.

Let’s dive in.

RASolute 302: Daraxonrasib vs investigator’s choice chemotherapy in previously treated metastatic pancreatic cancer
Abstract LBA5 (soon!)
Presentation: May 31, 2026, 3:21-3:33 PM CDT

For decades, pancreatic cancer has been where good ideas go to die.

We have optimized chemotherapy. We have sequenced chemotherapy. We have celebrated modest gains.

But the central driver of PDAC has always been sitting there in plain sight:

RAS.

More than 90% of pancreatic cancers have oncogenic RAS mutations, and until recently, we had essentially nothing direct to do about it.

Daraxonrasib is an oral RAS(ON) multiselective inhibitor targeting the active GTP-bound state of mutant and wild-type RAS.

And in RASolute 302, it delivered.

Quick hits:

📌 Phase 3 international randomized trial 500 patients with previously treated mPDAC Daraxonrasib vs investigator’s choice chemotherapy

🧬 RAS G12 population
91.8% of patients had RAS G12 mutations

📈 OS in RAS G12 population
13.2 vs 6.6 months
HR 0.40
P<0.001

📈 OS in overall population
13.2 vs 6.7 months
HR 0.40
P<0.001

📊 PFS in RAS G12 population
7.3 vs 3.5 months
HR 0.45
P<0.001

📊 PFS in overall population
7.2 vs 3.6 months
HR 0.49
P<0.001

🔥 12-month OS
Overall population: 53.2% vs 17.3%

⚠️ Toxicity matters, but this was not just more efficacy for more toxicity
Grade ≥3 AEs: 61.8% vs 69.6%
TRAEs leading to discontinuation: 1.2% vs 11.2%

This is the kind of survival curve we almost never get to see in pancreatic cancer.

This validates RAS(ON) inhibition in the most RAS-addicted major cancer. It takes a target we have talked about for decades and turns it into a clinically meaningful survival benefit in a randomized phase 3 trial.

The next questions come fast: 1L combinations, maintenance, perioperative disease, sequencing, resistance, toxicity management, and whether this becomes a new backbone.

RAS is here, and it couldn’t have come sooner.

https://t.co/Y4WJRlRRTk

@TheGutonclab @UGrewalMD @TimothyJBrownMD @OncoAlert @Onco_Nexus @ASCO
@NazliDizman @LauraAlderMD @DVAraujoMD @DrBarbiOnc @LauraEsfeller @FunchainMD @YGaritaonaindia @DrSAHaddad @jgong15 @iandresmeraz @SakditadMD @RamilaShilpakar @RohitBanwar @lungoncdoc

[Mark Lewis, MD, FASCO @marklewismd]

Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer

Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived

#ASCO26

[ALUTHEDON @Mbakaza4L]

this should hurt to look at. this should make you feel sick. this is one of the worst tragedies in human history and you can see it from space.

[Zy0x @Zy0x_]

LOHEN LOOKS TOO GOOD BRO

[Sun | ia @SunKefi]

@MJippers I love this so much, oh my gosh! Wonderful interpretation!

[인삼 @gosamtti2]

이 일러가 진짜 좋은게 점점 안으로 갈수록 경계하면서 자신을 감싸는게 ㄹㅇ 키프리임… 비밀을 알려준듯 싶다가도 절대 끝까지 알려주지않아

[Stealth @Stealth40k]

Fire Emblem Awakening is 14 years old!

Awakening saved the series. If it didn't sell above 250,000 units, Nintendo was reportedly going to retire Fire Emblem.

It ended up selling ~2m units. Every Fire Emblem since has sold at least 1m with Three Houses selling ~5m.

[Sun | ia @SunKefi]

@ramyeon_ssi Good luck!!! 🩷🩷

[YEON 🌹 VGEN OPEN @ramyeon_ssi]

I cannot do graphics design to save my life but hear, hear! Skeb cms at VGen, last 8 slots priced at $50!

I'll have to raise my prices after this because of economy things going SUPER downhill, BUT I will open more non-skeb options once the slots cleared out.

RTs appreciated!

[хуба буба 🦐 @kirivetika]

Bonsai
#Δ帽子 #witchhatatelier

[Assad Bajwa @oyebajwey]

Being a doctor tops the list

[🕸クリスマスの枝豆2nd season🎃 @fooniD_Omame]

【 Welcome to my memorial space. 】

⚠️Cos spoiler / OMORl ⚠️

You have been living here as long as you can remember.

[AmazingArtistYellow @AAnimatorYellow]

Fly, Pit, FLY!
#KidIcarus

[Dr. Priyam Bordoloi @DocPriyamMD]

Medical horror level: 10/10. 🤯

Imagine dying not because you got cancer, but because your tapeworm did.

​A @NEJM case report documented a man whose Hymenolepis nana parasite developed malignant stem cells. These tapeworm cancer cells then metastasized into the human host's lungs and lymph nodes.

​It’s the first known case of a parasite "sharing" its cancer with a human. Medicine is officially stranger than fiction

[Sun | ia @SunKefi]

@saikenMD Nooo your work hours as an attending are still such ass 😔 sorry bro

[수리 @suri_701]

#TGCF #天官赐福 화성