The Secretome

The secretome news! All about paracrine soluble factors produced by cells and used for communication:exosomes, vesicles, small proteins… Host:@martagarciacon2

[Ali Ghoochani @ali_ghoochani]

Excited to share our new paper, in collaboration with @AOri_lab, @blue_ceil is out at Cell!
Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder: Cell https://t.co/eyIirVZIpl
@abu_remaileh, @Stanford, @Stanford_ChEMH, @ASAP_Research, @BrainResilience, @czi
#Neuroscience , #Cellbiology, #biology

[Luke McIlvenna @LukeMcIlvenna]

Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma
https://t.co/IOZza3HIFV

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

State-dependent release of extracellular particles with distinct α2,6-sialylation patterns and small RNA cargo related to neuroinflammation https://t.co/Dggd84SKSJ

[2048 Ventures 🧬 🤖 ⚙️ @2048vc]

🗞️ 2048 Ventures Portfolio Company News:

nELISA: a high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome

https://t.co/XcnSWmIYBB

@nomicbio // @2048vc // #startups // #VC

[The Secretome @TheSecretome]

The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan | ⁦@NatureAging⁩ https://t.co/mltraLeMu4

[The Secretome @TheSecretome]

p21 produces a bioactive #secretome that places stressed cells under immunosurveillance ⁦@ScienceMagazine⁩ https://t.co/Hriw8wfVnu

[Exodus Bio @exodus_bio]

Just days away—#EXODUSSymposium2025 starts this Friday!
✨ Experts from Harvard, MGH, Capricor, Aruna Bio & Versatope Therapeutics
⚡ Registration closes Sept 23, 6PM EST
Don’t miss top insights in EVs research, clinical translation & biotech innovation!
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[Dan Lark @ERM_Lab]

An awesome new discovery from @VanderbiltU. Blebbisomes - extracellular vesicles (EVs) that transport functional mitochondria and can traffic their own exosomes. Pretty fascinating addition to the list of "cell-like" particles found in the circulation...
https://t.co/ipJskZyut2

[GEIVEX @GEIVEX]

Convocatoria extraordinaria por la DANA - https://t.co/oW0eJxFaAG -
La junta directiva y entendemos que tod@s l@s soci@s de GEIVEX estamos sobrecogid@s por las consecuencias que ha tenido en el levante la última DANA, y esperamos que tod@s nuestr@s soci@s y sus allegad@s se...

[Marta Vilademunt @MartaVilademunt]

Excited to share our lab preprint with the work of Charline Carron. I am happy to be a listed author!

The main findings highlight astrocyte secreted peptide PEA116 as a regulator of the early steps of adult neurogenesis and mood disorders. Check it!

https://t.co/zUuDBhoRzz

[The Secretome @TheSecretome]

#SARS -CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (#CKAP4) https://t.co/MQhD8Uq174

[Ali Ghoochani @ali_ghoochani]

I am thrilled to announce that our work in collaboration with Alessandro Ori’s lab @AOri_lab, @Blue_ceil is out!

We made a significant breakthrough in understanding the role of lysosomes in the brain with the development of the first cell-type-resolved lysosomal protein atlas. This comprehensive map details the lysosomal proteome across major brain cell types—neurons, astrocytes, microglia, and oligodendrocytes.
@abu_remaileh @Stanford_ChEMH, @ASAP_research, @BrainResilience, @CZI @cziscience
Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder https://t.co/LNJxjuR3Vb

[The Secretome @TheSecretome]

Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome ⁦@NatureAging⁩ https://t.co/aC1ecN3wPQ

[The Secretome @TheSecretome]

Insulin-Independent Regulation of #Type1Diabetes via Brown Adipocyte-Secreted Proteins and the Novel Glucagon Regulator #Nidogen -2 |⁦@biorxivpreprint⁩ https://t.co/wxfIXxhgWw

[The Secretome @TheSecretome]

Self-Referenced Au Nanoparticles-Coated Glass Wafers for In Situ SERS Monitoring of Cell Secretion https://t.co/XLi2CEUEw6

[The Secretome @TheSecretome]

Schwann cell-secreted PGE2 promotes sensory neuron excitability during development ⁦@CellCellPress⁩ https://t.co/TnM3TxsUv0

[The Secretome @TheSecretome]

Guidelines for minimal information on cellular #senescence experimentation in vivo ⁦@CellCellPress⁩ https://t.co/0WIMWn5uHq

[The Secretome @TheSecretome]

#Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis | ⁦@NatureComms⁩ https://t.co/hyOTIGFkn8

[The Secretome @TheSecretome]

Control of cholesterol-induced #adipocyte #inflammation by the Nfe2l1-Atf3 pathway | ⁦@biorxivpreprint⁩ ⁦@BarteltLab⁩ https://t.co/7bozJ5ZUYG

[bioRxiv Neuroscience @biorxiv_neursci]

Secretome analysis of oligodendrocytes and precursors reveals their roles as contributors to the extracellular matrix and potential ... https://t.co/K8WzFu1Xi6 #biorxiv_neursci