Ubigene Bioscience

Specialists in CRISPR-based gene editing and screening.
We deliver high-quality gene editing services and products to researchers worldwide.

[Ubigene Bioscience @ubigene]

A new look for UBIGENE!

Inspired by gene editing, our new logo brings together three key elements: a delivery arrow, a cell, and a DNA-inspired molecular scissors symbol.

Our visual identity is evolving, but our commitment to making gene editing easier for researchers remains unchanged.

#UBIGENE #GeneEditing #CRISPR

[Ubigene Bioscience @ubigene]

Recovering a CRISPR library cell pool: why does cell number matter?

The basic thawing procedure is similar to that used for conventional cell lines. However, recovering a CRISPR library requires one additional consideration: maintaining sufficient sgRNA coverage.
In this video, we demonstrate the recovery of hGeCKO Library A#2 in THP-1 and walk through the key steps, including:
• Calculating the required cell number based on sgRNA coverage
• Processing multiple cryovials as a group
• Minimizing DMSO exposure during thawing
• Pooling and evenly distributing the recovered cells
• Evaluating cell morphology 24 hours post-thaw
For a CRISPR library, the goal is not simply to recover viable cells, but to recover enough cells to maintain adequate library representation.

#CRISPR #CRISPRLibrary #CRISPRScreening #FunctionalGenomics #GeneEditing #CellCulture

[Ubigene Bioscience @ubigene]

Save months of lab work! 🧬 Get WB-Validated KO Cell Lines for only $2,380!

Ubigene’s upgraded bank features 10,000+ KO lines covering top research targets—fully validated by PCR, Sanger, and Western Blot.

🚚 Delivery in 1-2 weeks! 🎓 Academic exclusive. ⏰ Ends July 31, 2026.
Check your target now 👇
https://t.co/uZC58yaIzA
#CRISPR #GeneEditing #CellBiology #KnockoutCellLine #AcademicResearch #WesternBlot #AcademicTwitter #PhDlife #Biotech

[Ubigene Bioscience @ubigene]

CRISPR screening is revolutionizing how we find the next blockbuster drug. 💊✨

From identifying novel targets to decoding drug resistance, the trends are clear: high-throughput functional genomics is the future of R&D.

Check out the latest insights on CRISPR Screening in Drug Discovery and see how it's accelerating the therapeutic pipeline.

Full article here: 👇 https://t.co/KukvJPuedn
#Biotech #Pharma #CRISPR #DrugDevelopment #Ubigene

[Ubigene Bioscience @ubigene]

Raw sequencing data ≠ Validated hits. 📊
Are you accounting for "Algorithm Bias" in your CRISPR screens? Learn how to filter out the noise and achieve high-confidence results for CRISPR Knockout, CRISPRi, and CRISPRa for Cell pools.

Precision in analysis is just as vital as precision in editing. 🧬

Explore our technical guide: 👇 https://t.co/TGmU0KI1zD

#CRISPR #Biotech #DataScience #Genomics #Ubigene

[Ubigene Bioscience @ubigene]

Leveling up #CRISPR precision! 🧬 A new study on AcrIIA27 and sgRNA-PTP shows that RNA truncation can significantly enhance editing efficiency.

By refining the "on-switch" for CRISPR systems, we're getting closer to safer, more controllable gene therapies.

The technical breakdown: 🔗 https://t.co/WTbE9XX98G
#GeneEditing #BioTech #CRISPRcas9 #MolecularBiology

[Ubigene Bioscience @ubigene]

The future of #PrecisionMedicine is being rewritten. 🧬 The Nature Outlook 2026 highlights how gene editing is moving from "niche" to "standard of care."

Key shifts: 🔹 In vivo delivery breakthroughs 🔹 AI-driven tool design 🔹 Regulatory clarity
Read the full deep dive: 🔗 https://t.co/Z4jg2GASN4
#GeneEditing #CRISPR #Biotech #NatureOutlook

[Ubigene Bioscience @ubigene]

How does m6A methylation drive Colorectal Cancer? 🧬

The m6A-YTHDF1-Notch1 axis is a major driver of CRC stemness. Understanding this "reader" mechanism opens new doors for targeted therapy.

🔗 Molecular details here: https://t.co/qjTxAsXy7i
#CancerResearch #Epigenetics #CRC #Biotech

[Ubigene Bioscience @ubigene]

Struggling with HTR-8/SVneo transfection? 🧪 High efficiency in trophoblast gene editing is possible!

Check our latest technical breakdown on culture optimization and CRISPR tips for the HTR-8/SVneo line.

👇 Full guide here: https://t.co/HwfkKHH2Ek
#Biotech #LabLife #CRISPR #CellBiology

[Ubigene Bioscience @ubigene]

🔬 New Insights in B-ALL Therapy!A recent @NatureCancer study reveals a unique vulnerability in B-cell acute lymphoblastic leukemia. Unlike solid tumors, B-ALL cells rely on efficient β-catenin degradation to survive.
Key Discovery via CRISPR Screens: 🎯 GSK3β inhibitors block β-catenin degradation. 🎯 Accumulation of β-catenin suppresses MYC via Ikaros/NuRD complexes. 🎯 A promising targeted strategy for refractory B-cell malignancies!

Read the full analysis:🔗 https://t.co/lsG1XKaeS7
#LeukemiaResearch #CRISPR #CancerGenomics #Biotech #B_ALL #Ubigene

[Ubigene Bioscience @ubigene]

🔬 New Breakthrough in Immunotherapy!Researchers from Southern Medical University reveal how #Uridine can be a "game changer" for ICB resistance.
The study identifies the SNX17-RUNX2-UPP1 axis: ✅ SNX17 promotes uridine depletion in TME. ✅ Uridine supplementation boosts CD8+ T cell activity via CD45 N-glycosylation. ✅ A low-cost strategy to synergize with anti-PD-1!

Read the full case study:🔗 https://t.co/VsRJRWm2dY
#CancerResearch #Immunology #CellMetabolism #Biotech #Ubigene

[Ubigene Bioscience @ubigene]

🚀 A new breakthrough in gene integration is here.

The LOTI strategy enables high-efficiency, precise in vivo knock-in of large DNA fragments, while minimizing off-target effects.

From basic research to gene therapy — this could change the game.

🔬 Learn how it works:
https://t.co/lRgVeW65tn
#CRISPR #GeneEditing #Knockin #GeneTherapy #GenomeEngineering

[Ubigene Bioscience @ubigene]

CRISPR library screens are powerful, but algorithm bias can skew your gene hits! 🧬 Standardizing analysis workflows ensures reliable results for your research.
👉 Read more: https://t.co/JeIBUEAwR8
#CRISPR #GeneEditing #DataAnalysis #BioTech #Ubigene

[Ubigene Bioscience @ubigene]

🚀 Accelerate your research with Ubigene’s Spring KO Cell Sale!

Get FREE parental cells with any catalog KO cell line purchase. ✅ 8,000+ In-stock products ✅ Starts from $1980 ✅ 1-2 week delivery
Limited time: Mar 16 - Apr 17. For academics only! 🎓
Check it out: https://t.co/AqGUakvPQc
#CRISPR #GeneEditing #Biotech #CellBiology #LifeScience #Ubigene

[Ubigene Bioscience @ubigene]

🧬 How do you build precise point mutation cell lines?

From RNP-HDR and base editing to prime editing, different strategies enable accurate SNP modeling for disease research and drug discovery.

📄 Practical construction guide:
https://t.co/EbOP6326EF
#CRISPR #PointMutation #GeneEditing #FunctionalGenomics

[Ubigene Bioscience @ubigene]

Precision is everything in Gene Editing. 🎯
Generating point mutation cell lines can be tricky. We’ve summarized the 4 core methods you need to know:
RNP, Base Editing, Prime Editing and Antibiotics KI
Full breakdown here: https://t.co/X92wuYfZhd
#CRISPR #GeneEditing

[Ubigene Bioscience @ubigene]

Building a CRISPR KO cell line? Avoid the common pitfalls of poor gRNA design and suboptimal delivery. 🧬

Our latest guide breaks down the full workflow for maximum success: https://t.co/n0uLXIFBY3

[Ubigene Bioscience @ubigene]

🚀 New Year, New Precision!
Achieve high-efficiency point mutation cell lines with Ubigene’s EZ‑HRex™ technology.

🔹 Verified monoclonal cells
🔹 Special New Year offer: $4,980
Boost your research today!
🔗 https://t.co/9i6NsEIRHA
#PointMutation #CellLine #CRISPR #Biotech

[Ubigene Bioscience @ubigene]

🧓 CRISPR screens reveal why senescent cells survive.
Senescent cells rely on cFLIP to block DR5-mediated apoptosis, exposing a state-specific senolytic vulnerability.
👉 https://t.co/CefzatLufQ
#Senescence #Senolytic #CRISPRScreen #FunctionalGenomics

[Ubigene Bioscience @ubigene]

🦠 GPNMB blocks autophagy to aid bacterial survival.
By disrupting STX17–SNAP29 SNARE assembly, GPNMB inhibits autophagosome–lysosome fusion.
👉 https://t.co/xScn1LGmai
#Autophagy #SNARE #Immunology #GeneKO