𧬠Fascinating translational work from @BraunMDPhD lab by Dr. Rout at #AACRkidney2026
Single-cell transcriptomics of tumor-infiltrating CD8+ T cells in ICI-resistant RCC π¬
Key findings:
β‘οΈ Insufficient T cell infiltration is a core feature of ICI resistance in RCC
β‘οΈ TGFB1 emerges as a potential driver of the exhausted resident memory T cell phenotype
β‘οΈ This Tex-rm phenotype correlates with resistance to immune checkpoint inhibition
Why this matters: π‘ TGFB1 has long been implicated in immune exclusion, but pinpointing its role in shaping a specific exhausted T cell state in RCC gives us a more precise therapeutic target
If TGFB1 is locking CD8+ T cells into an exhausted resident memory fate or excluding CD8 T cells from TME, anti-TGFb strategies combined with ICI may deserve a closer look in biomarker-selected RCC patients π―
Single-cell resolution is revealing what bulk analyses miss. This is the kind of mechanistic work that drives the next generation of rational combinations. π
#KidneyCancer #RCC #Immunotherapy #ICIResistance #TGFbeta #SingleCell #Tcells #GUOnc #AACRkidney2026
Visit us at the Piscataway Library on March 28th from 11 AM to 3 PM for a hands-on biology experience! Step into the role of a forensic scientist, explore real lab techniques, and get a taste of what itβs like to work in a forensic lab. @NJSTEMPathways@MakersDay#STEM4All @4h
We are so proud that Reeti from our club participated in the National 4-H Roth Scholarship program. She was selected to take part in this national leadership program and presented her year-long project in DC to the national 4-H this past week!. Congrats!
@rrout_ @4H @wemake4h
We had an amazing time holding the #STEMSummit this past weekend! ππ¬ With 75+ youth attendees, hands-on STEM exhibits, and inspiring conversations, the energy was off the charts. We are grateful to everyone who helped make this event a success! @WeMake4h@NJSTEMPathways
π STEM SUMMIT 2025 π
Join us on April 6th @ 2:30 PM for an exciting dive into the future of AI, Robotics, Computer Science, and more!!
π€ Expert Panels
π Free Giveaways
π¬ Endless Innovation
Donβt miss out!!
@njstempathways @njsaacc @4h @wemake4h@ngcproject
Applications are now open to join the NGCP Youth Advisory Board for the 2023-2024 school year! High school students with a passion for #STEM from diverse backgrounds are encouraged to apply.
Application deadline is October 6, 2023. #YouthVoices https://t.co/LmfcT8zNhk
π€π We held an exciting showcase of Robots & Drones at the Middlesex County Fair! Attendees dived into a tech-forward tomorrow, experiencing with FTC bots to high-flying drones!
#MiddlesexFairTech#Robotics#DroneExpoπΈ@4H @rrout_
Congratulations to our 2023 STEM Civic Leader of the year, @rrout_! This award is given to an organization or individual who demonstrates extraordinary civic leadership in STEM in their community through volunteerism, training or mentoring others.