Yi Lab

Studying skin biology, gene expression regulation at the genomic scale, stem cells and more in magnificent Chicago

[Yi Lab @Yi_Lab_NU]

Congrats to @arpandas71 to successfully defend his thesis! Arpan’s study has addressed an important question of sebaceous gland fate specification. His beautiful work creatively connects miRNA, WNT signaling and SOX9 TF together. A true tour de force and amazing accomplishment!

[Yi Lab @Yi_Lab_NU]

https://t.co/PJgXkp24zC
Very happy to share the thesis work of our great @arpandas71 . Starting from an observation of miR200 induction strongly inhibiting sebaceous gland fate, Arpan used all tools at his disposal to reveal the new biological insights. A true tour de force!

[Yi Lab @Yi_Lab_NU]

Congrats to @cadyyuheng to graduate from the DGP in 4 years after joining our lab in 2021. Cady is our first ever graduate student at Northwestern, and she has heralded a new era of single cell spatial transcriptomics in the lab. We wish her the best and continued success at SF!

[Yi Lab @Yi_Lab_NU]

@CAM_NUChicago cannot do it w/o the help from CAM, our world class imaging center at Northwestern!

[Yi Lab @Yi_Lab_NU]

The surprising findings are 1) the force of 20pN through Ecad is sufficient to activate PIEOZ1; 2) AP1 factors control numerous ECM and actin genes in stem cells. How to leverage force to control hair growth is our next focus!

[Yi Lab @Yi_Lab_NU]

Excited to share our new work in collaboration with @JieYan_NUS and @KathyGreenLab We 1) determined 20pN force through E-cad is sufficient to activate PIEZO1; 2) quantified Ca dynamics and identified their downstream targets in hair follicle stem cells.
https://t.co/cscXwKOxYn

[Yi Lab @Yi_Lab_NU]

Congrats to our exceptional graduate student, Chris Stephens, to receive a prestigious NIH F31 predoctoral fellowship to study metabolism in the skin!

[Yi Lab @Yi_Lab_NU]

Congrats to our fantastic dermatology fellows, Ed and Steve, to receive prestigious Dermatology Foundation Career Development Award and Research Fellowship. Steve also won a Skin of Color Society research award.

[Yi Lab @Yi_Lab_NU]

Congrats to @cadyyuheng to successfully defend her beautiful thesis work of single cell genomics of the skin. Thanks @kjgreen47 @yogeshgoyallab and @Rosemary_Braun. Due to @dgpnorthwestern procedures, Cady will publicly present her work next Wednesday. Let celebration begins!

[Yi Lab @Yi_Lab_NU]

Very excited to share our newest tool: scHolography for reconstruction and quantitative analysis of spatial neighborhoods. Fantastic work by @cadyyuheng and collaboration with @Rosemary_Braun. Visit https://t.co/zhMSk0uVof for tutorials.

https://t.co/R2Z1DK0cpA

[Yi Lab @Yi_Lab_NU]

Also we have @cadyyuheng’s spatial transcriptomics paper accepted by @GenomeBiology today, 11 years after Jie published his thesis work there. Very proud of our fantastic students.

[Yi Lab @Yi_Lab_NU]

A full-circle day for the Yi lab! Our very first graduate student, Zhaojie, visited the lab during ASCO. Jie is now data science director at Moderna, and he discussed his exciting clinical oncology work while our newest student, @carolynng0, presented her very first lab meeting.

[Yi Lab @Yi_Lab_NU]

It’s the time of the year. Let’s first congratulate our two Harvard-bound students. Ayasa is our research assistant and she will join the graduate program at Harvard biology. Anisha is an IMSA student ,and will join Harvard college as undergraduate student this fall.

[Yi Lab @Yi_Lab_NU]

The results, from both studies, suggest oxidative phosphorylation (mitochondria), cell adhesion and robust differentiation are key to hair growth and aging.

[Yi Lab @Yi_Lab_NU]

In our analysis of single cell transcriptome and open chromatin during aging, @_Chi_Zhang found the transcriptome of hair follicle stem cells is influenced by the hair cycle whereas their niche is less sensitive. https://t.co/Jp7oGdeg4p

[Yi Lab @Yi_Lab_NU]

Happy to share two of our newest studies. In the study of MOF and H4K16ac, we found essential functions of MOF in controlling mitochondria and primary cilia in the skin. The regulation is prominently mediated at gene promoters. https://t.co/VZuprgy1VW

[Yi Lab @Yi_Lab_NU]

There’s no better feeling to send off our first research assistant, Michael Sande, to embark on his new journey at graduate school! Wishing him all the best at UW Madison. Go conquer, Michael!

[Yi Lab @Yi_Lab_NU]

@JieYan_NUS @srikalaraghava1 @kjgreen47 Thanks , Jie. May the force be with us :)

[Yi Lab @Yi_Lab_NU]

Super excited to share our newest study of mechanical properties of hair follicle stem cells and manipulate mechanical forces to activate hair growth by using a microRNA in collaboration with @srikalaraghava1 @JieYan_NUS @kjgreen47 https://t.co/RDQGhRQ8tK

[Yi Lab @Yi_Lab_NU]

Congratulations to Michael Sande, our first research assistant at Northwestern, on securing admission to the Cellular & Molecular Pathology graduate program at University of Wisconsin!