🤯 JUST IN: INCREDIBLE PHASE 3 DATA ON RETATRUTIDE PRESENTED AT ADA
At ADA this weekend, Eli Lilly ($LLY ) presented new Phase 3 data from TRIUMPH-1 and TRANSCEND-T2D-1. BLUF: 28% (70 pounds) weight loss. Unreal.
In TRIUMPH-1, participants receiving 12 mg of retatrutide lost an average of 70.3 pounds (28.3%) over 80 weeks. Nearly half achieved at least 30% weight loss, and 65.3% were no longer classified as obese (BMI <30) by the end of the study. Among participants who started with BMI ≥35 and continued treatment to 104 weeks, average weight loss reached 85 pounds (30.3%), with no evidence that weight loss had fully plateaued.
What stood out more was the breadth of effect across obesity-related conditions:
Knee osteoarthritis pain improved by 73.1%
Obstructive sleep apnea severity improved by 60.6%
Triglycerides fell by as much as 41.0%
Non-HDL cholesterol declined by 24.2%
Systolic blood pressure dropped by 12.3 mmHg
Waist circumference decreased by 9.5 inches
Meanwhile, in TRANSCEND-T2D-1, retatrutide produced A1C reductions of up to 2.0% from a baseline of 7.9%.
90% of patients achieved A1C <7%
85% achieved A1C ≤6.5%
46% reached A1C <5.7%, which is below the threshold used to define prediabetes
Patients lost 36.6 pounds (16.8%) at 40 weeks, and weight loss was still ongoing at study end.
Obesity medicine is increasingly becoming outcomes medicine.
Historically, we have evaluated obesity drugs primarily on percent weight loss... but payers ultimately care about sleep apnea, osteoarthritis, diabetes, cardiovascular risk, and healthcare costs.
The significance of TRIUMPH-1 and TRANSCEND-T2D-1 is that Lilly is beginning to show a coherent story across those endpoints, not just body weight. I expect this to expand coverage dramatically.
Eli Lilly is the Nvidia of healthcare.
A new study of more than 111,000 women ages 45 to 80 found those on GLP-1 medications had a reduced risk of developing breast cancer by about 30%. https://t.co/d88z6D6YBQ
City vibes are hard to explain right now. There’s a guy smoking a cigar and holding a broom and everyone is shaking his hand as if he’s an essential worker during the pandemic.
Right now, there are several toddlers in New York City who don’t know it yet, but they’re not going to be going to college because their parents just decided they need to be at Game 4 no matter what.
🔴 D’après nos sources, la FECAFOOT aurait fixé à plus de 95 millions de FCFA le montant requis pour la tenue d’un match amical hors du Cameroun, en plus d’exiger la prise en charge intégrale de l’effectif et de son hébergement. 🇨🇲🦁 #Lequipe237
🚨 BREAKING! 🤯
Florentino Pérez: “I will send a €150m bid on Tuesday for a top player from a Champions League team.”
“He is NOT Erling Haaland.”
“He is a superstar of the level of Cristiano Ronaldo.”
🔥 Real Madrid's presidential election debate has been brilliant tonight:
• Enrique Riquelme announces an interview where he will name his superstar.
• Just as the interview starts, Florentino Perez officially announces Jose Mourinho as his coach.
• Riquelme finds out during the interview that Mourinho is announced, and says his coach is someone different - a manager according to him, that is a superstar.
• Enrique Riquelme announces Erling Haaland as his superstar signings & Rodri too.
• Riquelme says he will pay 100% of the membership fees for Real Madrid members if he doesn't keep his promise of bringing Haaland and Rodri.
• Just as the interview of Riquelme ends, an interview of Florentino Perez drops on Diario AS.
• Florentino Perez announces Mourinho & Ibrahima Konate as his first signings.
• He says he will bring another top defenders & strengthen the team in every position - promising an incredible team for next season.
On Sunday, we find out the winner. 👀