We quantified mRNA abundance, translation, protein abundance, protein degradation and cell growth across thousands of single cells from a mammalian tissue.
The results revealed 𝐜𝐨𝐦𝐩𝐥𝐞𝐱 regulation & 𝐬𝐢𝐦𝐩𝐥𝐞 organizing principles:
https://t.co/KbhYkJDKPt
🧵
Very pleased to see our chapter on Muscle Proteome Dynamics published in The Skeletal Muscle: Plasticity, Degeneration and Epigenetics - A collection of brilliant chapters from leading researchers on muscle biology.
https://t.co/kBhjDu1osR
- People with obesity exhibit losses in muscle proteostasis that are partly improved by exercise training -
Cool new article by @ExercProteomics, @mackinprof
& Co.
https://t.co/jHLEg5HdV1
People with obesity exhibit losses in muscle proteostasis that are partly improved by exercise training
https://t.co/DF6L8u3Y7B
Obesity and insulin resistance are associated with compromised muscle proteostasis, which may be partially restored by endurance exercise.
Interested in muscle ageing?
Join us at the Healthy Muscle Aging Conference in Liverpool on September 15th
Registration is open now and you can be in with a chance to win FREE REGISTRATION
Full details: https://t.co/bpaLlahSKg
#HMAC2023
Healthy Muscle Ageing Conference @LJMU https://t.co/urWSV84gMO
The first Healthy Muscle Ageing Conference (HMAC), here at Liverpool John Moores University (LJMU).
IN PRESS
THP:
- RT ⬆️ strength, hypertrophy & physical function VS no exercise
- Load, volume, frequency, exercise order impact strength gains
- Volume and contraction type impact hypertrophy
Nice work team! @mackinprof@MACleod_JC
https://t.co/leDMc558nT
SAVE THE DATE - Healthy Muscle Ageing Conference
15 September 2023 - more details coming soon
From one of our pump-priming projects led by
@ExercProteomics#TranslationalStudies
Our latest study on the effects of training following a low carbohydrate high-fat diet on skeletal muscle epigenetic regulation is now out in @AJPEndoMetab. (w/@DrAdamSharples @pete_gorski@dcturner93, @JamesyMorton)
https://t.co/yIXAUWgYvW
Results are not what we expected!🧵 1
Muscle of obese insulin-resistant humans exhibits losses in proteostasis and attenuated proteome dynamics that are improved by exercise training. https://t.co/v3GkgxWLfX #bioRxiv
We are recruiting participants to study how protein supplements with/without Urolithin A impact muscle health during single-leg immobilization. Please share and contact me (see image) if interested!