Human BioMolecular Atlas Program (HuBMAP)

an NIH-funded consortium of scientists developing an open, global framework for comprehensively mapping the human body at a cellular resolution.

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

FOXJ1 - orange in epithelium, motile ciliated cells SCGB3A2 - pink - lung epithelial cells and submucosal glands SFTPB - pulmonary surfactant protein MUC5AC - bright blue - gel-forming glycoprotein in the lungs MUC5B - turquoise - gel-forming mucin protein

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Once again, the certified #_HuBMAP air-tists/researchers in Dr. Gloria Pryhuber's lab at @UR_Med hope to take your breath away with this multimodal image of airway epithelium, submucosal gland, and duct from the lung. We hope it respires you to live lung and prosper.

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Lung - Airway Epithelium and Submucosal Gland and Duct PTPRC - CD45 - Orange - immune cells PECAM1 - CD31 - Green - endothelial cells KRT5 - Yellow - basal epithelial cells ACTA2 - White - smooth muscle cells

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

follicles - red and blue, luteinizing cells - pink, extracellular matrix - purple, green, white, vessels - yellow and orange

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Does this CODEX image of an ovary send you ova the moon? This egg-citing image was made by NIH funded #_HuBMAP scientists @UPenn & @LurieChildren's, using antibodies specific to cell types found in the ovary to show the spatial relationships within. Ova it? Never!!!!

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Photo credit - UPenn & Lurie Children’s (O’Neill, Kim, Laronda)

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Not to be an ovary-achiever, but this CODEX image of oocytes in a healthy human ovary made by scientists at @UPenn & @LurieChildren’s is egg-straordinary! Images like this prove researchers aren’t just follicle-ing around! 😉

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Green – oocytes, Pink – extracellular matrix, Cyan – vessels, Blue and Yellow – epithelial cells

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Do you have the intestinal fortitude to check out your viscera? Then follow your gut instincts and digest this CODEX image of a healthy colon from John Hickey when he was at the of the Nolan Lab Stanford. We hope it bowels you over as much as us!

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Red - podocytes, green - endothelial cells, yellow - smooth muscle cels and arterioles, cyan - thick ascending limb tubules, blue - proximal tubules, brown - distal convoluted tubules

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Pi day just passed, so you know what that means! It's time for a slice of kidney pi(e), and that's a renal treat! This CODEX image of a kidney pi slice was made by #hubmap researchers Drs. Tarek Ashkar & Sanjay Jain @wustl, and we're not being irrational!

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Stroma and ECM - green and blue; Endothelium - red, white, magenta, and cyan; Macrophages - yellow

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Not to be ovary-serious, but this CODEX image of an ovary made by HuBMAP researchers Elizabeth Tsui, Hannah McDowell (Laronda lab at @NUFeinbergMed) & Alex Cabrera, Jean Rosario (O'Neill lab @PennMedicine) is egg-squiste! Hopefully, it fertilizes and catalyzesyour imagination!

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

https://t.co/bXV4XgjEuf

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

DYK that bone marrow makes your blood cells? To get to the meat of the matter, come see this MIBI-TOF image visualized in CellTune, a software that classified the cells across the tissue section. Not to be too bloody marrow-minded, but this CellTune software sings! 😊

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Yellow – lipid droplets, green – natural killer cells, light blue – endothelial cells, magenta – smooth muscle cells, orange – erythroid cell precursors, white – type I collagen, dark blue – hematopoietic stem cells

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Decided to see this mass spec image of the decidua from MikeAngeloLab @stanford? Excellent choice! The decidua lines the uterus during pregnancy & forms the placenta. This image also captures fetal cells within & around maternal spiral arteries because we always deliver for you!

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

Nuclei - blue, Immune cells - green, basement membrane - red, cardiomyocyte membranes - yellow, smooth muscle cells - cyan, endothelial cells - magenta

[Human BioMolecular Atlas Program (HuBMAP) @_hubmap]

To beat or not to beat that is the question
Whether 'tis nobler in the mind to skip a beat
Or pulsate with joy over the heartistry
Of an image made by @GEHealthCare
Using CellDIVE to see inner workings
Of the heart is work not done in vein
Tis a consummation devoutly to be wish'd

[Common Fund Data Ecosystem Knowledge Center @CFDEKC]

Mark your calendars for the @_hubmap Workshop on Jan 29th!
💻Hands-on intro to the HuBMAP Data Portal: ASCT+B tables, spatial & single-cell data, visualizations, downloads, and in-place analysis with Workspaces.
Apply by Jan 22 👉 https://t.co/JyEerr7E5D