Dario Tagliaferri

Biomedical Sciences Graduate Student @UCSF | Gene Fien | Certified Masshole | Formerly AbuGoot Lab @Harvardmed |

[Dario Tagliaferri @_Dariomics_]

Happy National GF day to the NextSeq 2000

[Chris Fell @ChrisWFell]

🚨 Today we report cryo-EM structures of Bxb1 integrase complexed with its attB/attP DNA substrates before, during and after recombination.

We engineer Bxb1 mutants with improved recombination and altered sequence recognition properties.

Out today @MolecularCell ⬇️

[Mark Lewis, MD, FASCO @marklewismd]

Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer

Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived

#ASCO26

[Dario Tagliaferri @_Dariomics_]

@trader1sz Alexander the Great meeting Diogenes

[Dario Tagliaferri @_Dariomics_]

DEMOLISH TD GARDEN

[Jarrid Rector-Brooks @jarridrb]

What if AI could invent enzymes that nature hasn’t seen? 👩‍🔬🧑‍🔬

Introducing 🪩 DISCO: Diffusion for Sequence-structure CO-design

14 rounds of directed evolution and over a year of wet lab work. That's what it took to engineer an enzyme for selective C(sp³)–H insertion, one of the most challenging transformations in organic chemistry.

DISCO surpasses this with a single plate. No pre-specified catalytic residues, no template, no theozyme, no inverse folding, just joint diffusion over protein sequence and structure.

📝 Blog: https://t.co/j9Za0JigfO
📄 Paper: https://t.co/ficrYNBBrM
💻 Code: https://t.co/p81sSwoaPH

[Dario Tagliaferri @_Dariomics_]

@NHL @NHLBruins How bout them Bs khed?

[Dario Tagliaferri @_Dariomics_]

I love that dirty water

[Dario Tagliaferri @_Dariomics_]

@BR_OpenIce @ConorRyan_93 He better be

[Only In Boston @OnlyInBOS]

Northeastern University's acceptance rate dropped to 5.2% for the Class of 2028.

[Dario Tagliaferri @_Dariomics_]

@BreeceH You gonna be an RB1 this season champ?

[Dario Tagliaferri @_Dariomics_]

BM63🥹

[Jared Carrabis @Jared_Carrabis]

The Red Sox really said to themselves, “I know it’s been five years and everyone already hates us for it and thinks we’re complete idiots, but how do we make the Mookie Betts trade look even worse? I got it. Let’s trade Rafael Devers a year and a half into his 10-year deal.”

[Dario Tagliaferri @_Dariomics_]

@Jiankui_He Blasphemy

[TatumsWrld @wrldoftatum]

@OrlandoMagic THOUGHT YALL WANTED BOSTON?!?!

HAVE FUN IN CANCUN LMFAOOOOOOO
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[Nature Biotechnology @NatureBiotech]

By combining high-throughput protein engineering with machine learning, bespoke SpCas9 enzymes are identified that outperform evolution-based and engineered nucleases and base editors in human cells. https://t.co/49qlqDxfDA #NBTHighlight

[Dario Tagliaferri @_Dariomics_]

@JuliaBauman2 @jgooten @omarabudayyeh @ChrisWFell Let’s gooooooooo

[Julia Bauman @JuliaBauman2]

I've been waiting for the day I could make this video!

Retrotransposons are reprogrammed for pretty efficient gene insertion up to 12.7kb in user-defined genomic targets. Small deletion + insertion possible too.

Awesome work from @jgooten @omarabudayyeh @ChrisWFell @lukas_villiger in @Nature

[Jiankui He @Jiankui_He]

Get in luddite, we're going gene editing

[Dario Tagliaferri @_Dariomics_]

@NHLBruins YESSSSSSS

[Dario Tagliaferri @_Dariomics_]

@TerrierHockey BTA sucks to BU 😂