Armando Cuesta, MD, MBA 🇺🇸

Physician-entrepreneur | MD/MBA @Cornell · Previously Postdoc @IcahnMountSinai | Husband & Father

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

@MrBeast 5,600,000 #promotion

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

@MrBeast 5,600,000

[Dr Jordan B Peterson @jordanbpeterson]

To the Americans:

I've travelled all over the world. I've familiarized myself with many places, and met many people. And I'm a Canadian, although I’m privileged to reside once again in the States.

And here's something I've noticed, and it’s a key element of America's continuing greatness:

You bloody Americans value success, and you believe in its existence.

This is something that doesn't really happen anywhere else in the world. Even in other free democracies—the United Kingdom; Finland, Sweden, and Norway; Australia, New Zealand and Canada; Germany, France, and the Netherlands (great countries all)—a counterproductive cynicism too often reigns.

Success is equated with exploitation.
Ambition is looked upon with contempt.

This happens sometimes in the United States too—particularly among the miserable progressives, who confuse their resentment, ingratitude and unearned skepticism with wisdom.

But in your great country, by and large, striving is admired and success celebrated.

This means that more people strive and succeed in the US than anywhere else. And it's increasingly obvious. You remain stunningly more innovative and productive than any people anywhere else on the planet.

And so I say, as all should who are fortunate enough to live in the western world, let alone America:

Thank God for the United States.

Thank God for the wisdom of its founders.
Thank God for its faith in the free market and in the natural rights of man.
Happy birthday, you damn Yankees and Southerners.

Long may your admirable country dominate the world.

Long may your freedom and hope provide an example to those suffering everywhere at the hands of their malevolent states.

May your two and a half centuries of unparallelled success be just the beginning.

Your country is the light of the world, and the city on the hill.

Thank God for the USA.

Happy 250th.

Dr. Jordan B. Peterson

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

America should stand for America. Period.

[Nick Sortor @nicksortor]

🚨 JD Vance is TORCHING Israeli government officials who are going after Trump

“What is your exact proposal?! You're a country of 9 MILLION people. You can't just KlLL your way out of solving every single national security problem that you have”

Wow!

[Martín Dandach @MartinDandach]

El Vicepresidente de Estados Unidos J.D. Vance se hartó de Netanyahu y empezó a atacarlo.

“Si yo estuviera en el gabinete israelí no atacaría al único aliado poderoso que me queda. Ya nadie los quiere. El Presidente Trump es el único que fue comprensivo con Israel. 2/3 de las armas que protegen su país fueron fabricadas por manos americanas y pagadas con los dólares de los impuestos de los contribuyentes estadounidenses. Si alguien piensa que el problema de Israel es Donald Trump necesita despertar”.

La relación entre Estados Unidos e Israel está peor que nunca.

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

Nobody does it like America🇺🇸. This is what the best country on earth looks like, and everyone else isn't even close.

[Mostly Peaceful Memes @MostlyPeaceful]

Dana White’s reaction watching the flyover is absolutely priceless

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

This is what Spain is capable of. A greatness it forgot it had. Great country, great men, extraordinary things.

[Trung Phan @TrungTPhan]

Entire fireworks and lightshow at the end of Pope Leo XIV’s La Sagrada Familia mass ceremony is incredible.

The final tribute to Antoni Gaudi includes part of one of the legendary architect’s most famous quotes: “To do things right, first you need love, then technique.”

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

@ArthurMacwaters The difference is the Shire’s evil came from outside. Ours is already in the walls.

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

For those that still think there’s a J curve that justifies it.

[Eric Topol @EricTopol]

The suppressed report that concluded there is no protective or safe level of alcohol consumption, now published. It was commissioned by US Congress
Report https://t.co/XmmsSo9q3q
Editorial https://t.co/8NuqBwkugM
"Despite the study’s adherence to its mandate, its findings were sidelined.”

[ABC.es @abc_es]

Increíble espectáculo lumínico y musical para despedir al Papa en la Basílica de la Sagrada Familia

Sigue la visita de León XIV a España en https://t.co/TUQ8FzYZO7

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

Interesting

[Peter Kuperman @p_kuperman]

Alpha School is building 4 types of high schools: Service, Division 1 Athletics, Entrepreneurship and "get into a Top 20 university" high schools:

Service high schools will be where you do things like spend a year in Africa building an Alpha School and doing your top 1% academics 3 hours a day, but on site on a different continent.

D1 Athletics high schools will be where you spend 5+ hours a day building yourself into an elite college athlete, maybe with professional aspirations. Again, you'll do your top 1% academics in only 3 hours a day, opening up most of your day to be an incredible athlete.

Entrepreneurship high schools like Founders School run by @nateliason will be where you learn how to earn a million dollars in profits during high school, starting at 12 pm, and only after doing your top 1% academics in only 3 hours a day.

"Get into a top 20 college" high schools will have a focus on giving you 40+ hours a week to build a portfolio of Olympic-level (academic) extracurriculars to go along side top 1% academics in only 3 hours a day.

The common theme here is that when it is possible to get a 1560+ SAT and 10+ APs during high school in only 3 hours a day, teenagers can open up their schedule to spend their years doing the stuff they want to at the highest levels.

This is much different than the best private high schools where classes and homework take up so much time that students only have at most ~20 hours a week to work on their passion projects and leadership activities.

Alpha School gives teenagers 2X+ the time, which makes for much more interesting people at the age of 18. That's why I'm building Toronto into the first 1,000+ student Alpha School city. Reach out if you are interested.

[Peter Kuperman @p_kuperman]

Alpha School is building 4 types of high schools: Service, Division 1 Athletics, Entrepreneurship and "get into a Top 20 university" high schools:

Service high schools will be where you do things like spend a year in Africa building an Alpha School and doing your top 1% academics 3 hours a day, but on site on a different continent.

D1 Athletics high schools will be where you spend 5+ hours a day building yourself into an elite college athlete, maybe with professional aspirations. Again, you'll do your top 1% academics in only 3 hours a day, opening up most of your day to be an incredible athlete.

Entrepreneurship high schools like Founders School run by @nateliason will be where you learn how to earn a million dollars in profits during high school, starting at 12 pm, and only after doing your top 1% academics in only 3 hours a day.

"Get into a top 20 college" high schools will have a focus on giving you 40+ hours a week to build a portfolio of Olympic-level (academic) extracurriculars to go along side top 1% academics in only 3 hours a day.

The common theme here is that when it is possible to get a 1560+ SAT and 10+ APs during high school in only 3 hours a day, teenagers can open up their schedule to spend their years doing the stuff they want to at the highest levels.

This is much different than the best private high schools where classes and homework take up so much time that students only have at most ~20 hours a week to work on their passion projects and leadership activities.

Alpha School gives teenagers 2X+ the time, which makes for much more interesting people at the age of 18. That's why I'm building Toronto into the first 1,000+ student Alpha School city. Reach out if you are interested.

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

If the twentieth century was the century of Mercy, this might be the century of the Eucharist.

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

Medicine trained me to never be wrong. Building trained me to be wrong fast. The hardest unlearning of my career: in the clinic, a wrong call hurts a patient. In a startup, refusing to make the call until you're sure IS the wrong call. Certainty is a luxury speed can't afford.

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

Drugs with human genetic support for the target are roughly 2x more likely to clear development. Yet capital still floods targets validated mostly in mice. The contrarian edge isn't a better molecule. It's refusing to drug a target nature never implicated.

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

"AI will replace doctors" gets the unit of work wrong. The bottleneck in medicine was never pattern recognition. It's accountability, ambiguity, and the 3am judgment call with missing data. AI eats the easy 80%. The hard 20% is the entire job.

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

@ILYA_babay Source-linking helps, but it's not a panacea. The harder failure mode: a perfectly cited claim that subtly misreads the paper. PubMed link to a phase 2 underpowered trial still "checks out." Provenance ≠ validity. The audit you can't outsource is appraisal.

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

Model size is the most overrated variable in clinical AI. Nobody at the bedside cares about parameter count. They care: does it fire at the right moment, in the existing workflow, with a reason I can act on? Most deployments die on integration, not intelligence.

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

Co-CEO of a biotech, CMO of an AI company, and most days I feel like a tourist in both. The credential that opened the door is not the competence that keeps me in the room. Impostor syndrome isn't a bug of switching fields. It's the receipt that you actually switched.

[Armando Cuesta, MD, MBA 🇺🇸 @acuestaMD]

Doctors optimize for not being sued. Founders optimize for not being forgotten. Those are opposite risk postures, and I've had to run both in the same skull. The lesson: defensive medicine keeps people alive; defensive building gets you killed. Know which game you're in.