Mark

all the 🏈

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. I've held dying hearts in my hands in the cath lab at 3 AM. And I need to tell you something that changes everything about how we prevent heart attacks.

For decades, the entire field was built on one target: lower LDL cholesterol. Statins save lives — that's settled science. But too many of my patients did everything right — took their statins, hit their numbers, lived clean — and still ended up on my table with a ruptured artery.

We were treating the smoke while the fire kept burning.
The fire is inflammation. And the evidence is now overwhelming.

The CANTOS trial proved it first — lowering inflammation independent of cholesterol reduced cardiac events. But the newer data is what keeps me up at night.

AI-enhanced CT angiography can now detect inflamed arteries by measuring changes in the fat surrounding your coronary vessels — the perivascular fat attenuation index. Higher inflammation in the fat around even one artery independently predicts cardiac death. When multiple arteries show inflammation, the risk multiplies dramatically — even in patients whose cholesterol looks perfect.

This isn't theoretical. This is measurable. Right now. On a scan you can get this month.

Low-dose colchicine — a drug that's been around for centuries for gout — is now FDA-approved specifically for reducing cardiovascular events. It works by quieting the inflammatory cascade that destabilizes the plaque sitting in your arteries. A pill that costs pennies is saving lives the statins couldn't reach.

And the next wave is already in Phase 3 trials. Ziltivekimab — an IL-6 inhibitor — targets the central inflammatory pathway driving atherosclerosis. Phase 2 data showed a 90% reduction in hsCRP. The ZEUS cardiovascular outcomes trial is enrolling now, with results expected late 2026 into 2027. If positive, anti-inflammatory therapy will become standard in managing heart disease alongside lipid-lowering. The era of inflammation-targeted cardiology is arriving.
But it goes deeper than drugs. AI is now predicting heart failure and cardiac events 5+ years before symptoms — integrating CT imaging, electronic health records, and genetic data with accuracy that jumps far beyond traditional risk calculators.

And polygenic risk scores — a simple genetic test that flags inherited cardiovascular risk — are now formally recognized as a risk-enhancing factor in the 2026 ACC/AHA guidelines. A single blood draw can reveal risk that's been silently building since birth. Decades before the first chest pain.

Here's what this means for you right now — today:
Ask your doctor for a high-sensitivity CRP test. It's cheap, routine, and measures the systemic inflammation that standard cholesterol panels completely miss. You can have perfect LDL and inflamed arteries that are quietly preparing to rupture.
If your hsCRP is elevated, discuss low-dose colchicine with your physician. It's FDA-approved for exactly this.
Push for a coronary CT angiography with AI plaque and inflammation analysis if you have risk factors. This isn't the stress test your parents got. This is 3D visualization of your actual arteries — with AI quantifying not just how much plaque you have, but what kind it is and whether the surrounding tissue is inflamed.
Consider polygenic risk score testing — especially with a family history of early heart disease. It's now guideline-supported.

And the foundation that never changes: move daily, eat real food, sleep 7-9 hours, manage stress, and know your numbers — ApoB, Lp(a), hsCRP, fasting insulin.
I left Iran as a child with nothing. I rebuilt everything in a country that gave me the freedom to become a physician. I've spent twenty years watching patients get second chances.

The ones who haunt me aren't the ones who died on my table. They're the ones who survived but never acted on what the science was telling them — years before the event that didn't have to happen.

You can have perfect cholesterol and still have a heart attack. Inflammation plus genetics can drive plaque rupture in arteries that look "fine" on a standard panel.
The myth that normal cholesterol means you're safe has cost more lives than I can count.

We now have the tools to detect the fire — not just the smoke. AI to see it. Genetics to predict it. Drugs to quiet it. And the ancient basics — movement, real food, sleep, purpose — to prevent it from starting.

Prevention is the new cure. And the science to make it real is no longer coming.
It's here.

[One Bad Dude @OneBadDude_]

California has overplayed their hand.

The entire country is watching.

[Mark @alltheFF]

@Seattlecfgirl @AdamHoyer @BretWeinstein I’m honestly surprised you went back and forth that long. Good on you 👍

[Nick shirley @nickshirleyy]

🚨 Meet Doris, she lives in California and is registered as a 126 year old who has voted in 51 elections and has NO IDEA.

California’s voting system is so corrupt that by simply knocking on the door of the “126 year old” proves election fraud.

EXPOSE IT ALL.

[Jillian Michaels @JillianMichaels]

This is all bullsh*t. Prior to 2014 California took 48 hours to certify. The Democrats put this system into place deliberately and systematically - NONE of this is "incompetence" or "lack of funds". You can follow the exact legislation Newsom and Brown signed into law to make this happen:
SB 29 (2014): Enacted the "postmark rule" (allowing ballots to arrive 3 days late) and extended the county canvass to 30 days to handle the influx.
AB 187 (2014): Aligned state timelines, giving the Secretary of State until Day 38 to officially certify the results.
SB 589 (2015) & AB 1407 (2017): Established the "ballot curing" framework, forcing counties to notify voters of missing or mismatched signatures and giving them a statutory window to fix them during the canvass.
SB 759 (2018): Standardized the cure timeline, mandating that counties allow voters to cure signature issues up to 2 days before the final certification.
AB 860 / SB 29 (2020–2021): Permanently extended the postmark arrival window to 7 days, further expanding the processing and signature-curing buffer within the 38-day limit.
Proposition 71 (2018): Delayed the effective date of ballot measures until 5 days after the 38-day certification to account for these extended counting and curing windows.

[Steve Hilton @SteveHiltonx]

Nearly a week into California's election shambles. The world is laughing at our inability to count votes in a timely manner. Where is Gavin Newsom?

No comment except to reject my plan to speed things up. We deserve better than a do-nothing, checked-out governor. Time for change!

[Mark @alltheFF]

If you don’t think CA Dems are cheating, you’re are fooling yourself

[Clandestine @WarClandestine]

What’s happening in California is nothing new. It’s the same playbook they used to steal 2020.

First they send out mass mail-in ballots, to everyone, even those who didn’t request them, and dead people still on the voter rolls.

Then they harvest all these floating ballots.

Then they delay counting for day/weeks, in deep blue counties they control, so they can continue to ship all these fraudulent mail-in ballots to the tabulation center, until they have enough to steal the election.

And that’s how it’s done. Completely untraceable election fraud.

This is why the Dems don’t want voter ID. It’s why they don’t want paper ballots. It’s why they don’t want same-day elections. It’s why they don’t want to clean up voter rolls.

This is how just a few deep blue counties in swing states, are able to overturn entire state and federal elections.

This is why securing elections is so important, whether that be via the SAVE America Act, or some sort of executive action. Until this problem is solved, we do not have a nation.

[🇺🇸RealRobert🇺🇸 @Real_RobN]

Here it is:

U.S. Press Secretary Karoline Leavitt:

“I’m happy to provide you all of the evidence.”

Gov. Gavin Newscum is under criminal review for signing up illegal aliens to vote through his criminal conspiracy—AB 37, universal mail-in ballots.

@PressSec: “I’m happy to provide you all of the evidence for it. I’d be glad to send that to you after this briefing. Fraudulent ballots are being mailed in in the names of other people, in the names of illegal aliens who shouldn’t be voting in American elections. There are countless examples, and we’d be happy to provide them…”

📝 PASS THE SAVE ACT:

How many fraudulent mail in ballots are being counted during the California rigged 2026 primary election?

The Democrats have banned voter ID across the country, but issues driver’s licenses to 20 million illegal aliens they’ve imported.

[Cernovich @Cernovich]

Universal mail in ballots, can’t ask for voter ID, and can’t audit ballots. Calling this election legitimate is Soviet era slop. Truly embarrassing to be pushing it. Would be better to say nothing than to degrade one’s self in this way.

[Mark @alltheFF]

@RichardCisneroe @brianeskow Illegal non-citizens voted en masse this primary. Thats why they don’t w the rolls audited

[Mark @alltheFF]

@AdamHoyer @BretWeinstein Use your eyes

[Bret Weinstein @BretWeinstein]

The rigging of the LA Mayoral primary is obvious. Outrage should be independent of party, and that’s not what I’m seeing. What’s wrong with you Blue Team people? Do you not understand what it means? Snap out of it and stand up for your neighbors, your country and the West!

[PeterSweden @PeterSweden7]

"White privilege" is a racist lie.

DEI is blatant systemic racism.

Woke is a form of social Marxism.

Reject it all.

No more discrimination.

[Mark @alltheFF]

@DecisionDeskHQ This is the beginning of the end of this…

[Lauren Chen @TheLaurenChen]

Mail-in ballots favor Democrats.

OK, fine.

Spencer Pratt was never going to lead in mail-in ballots.

But what is the justification for mail-in ballots received BEFORE the election vastly favoring Karen Bass, and the ones received AFTER the election favoring Nithya Raman?

[End Wokeness @EndWokeness]

In-person votes, for comparison:
🔴 Pratt: 34.5%
🔵 Bass: 29.4%
🔵 Raman: 26%

[Lee Kuan Yimby @LeeKuanYimby]

I do not ever want to become an election truther but how on earth does Raman completely annihilate Bass in these drops while her election day support was a very solid third place well behind both of them.

[Eric Daugherty @EricLDaugh]

🚨 HOLY SMOKES. President Trump just went berserk on the ELECTION FRAUD in California to Kristen Welker's face, and she melted down

"They're CROOKED just like YOU'RE CROOKED! You're either CROOKED or you're STUPID. You KNOW these elections are rigged." 🔥

"They're dropping fast because it's a RIGGED ELECTION! It's DAYS and they aren't even CLOSE. They're CHEATING on the election!"

WELKER: Do you have evidence?!

TRUMP: You just have to look! Do YOU think it's appropriate they have an election, five days+ they're nowhere CLOSE!

WELKER: They're slow

TRUMP: "No THEY'RE CROOKED! Just like you're crooked, the press is crooked and Meet the Press is crooked!"

"You play right into their hands with this crap. You know that these elections are rigged. Your network knows that they're rigged. You know that I won an election in a landslide. And I got 94% bad press. You know why I got that? Because you have no credibility."

BOOM!!!

[Mark @alltheFF]

@Keir_Starmer You are a modern day Neville Chamberlain