andrew

[andrew @Andrewhlwx]

wow

[Gina Milan @ginamilan_]

🚨 THIS is why the midterms matter.

In under 5 minutes, this guy explains why voting RED is critical and how Democrats and global forces are trying to kill Trump’s America First agenda.

You’re either Team America or you’re not. 🇺🇸

[Midnight Leaks @MidnightLeaksHQ]

🚨MAJOR BREAKING: The Surgeon General of Florida just announced ALL VACCINE MANDATES IN FLORIDA will be ENDED, and the room erupted.

All. Not just COVID. ALL.

JOSEPH LADAPO: "Every last one is wrong and DRIPS with disdain and slavery! Who am I, or anyone else, to tell YOU what you should put in your body? Who am I to tell you what your CHILD should put in their body? I don't have that right. Your body is a gift from God. What you put into your body is because of your relationship with your Body and God."

"Pretty much every state has them. It's WRONG."

Do you firmly support this decision?

A. Huge Yes
B. No

IF Yes, Give me a THUMBS-UP👍!!

MAKE THIS GO VIRAL ON 𝕏. LET’S GO 👏

[Tickled Orange @TickledOrange]

Thank God I Live In America | 250th Anniversary Song

"Thank God I Live In America & America Lives In Me"

Credit: Mystic Song Writer

[andrew @Andrewhlwx]

wow

[Elon Musk @elonmusk]

SPLC is guilty of incitement to murder Charlie Kirk

[andrew @Andrewhlwx]

MAAA 👏🏼👏🏼👏🏼

[Glenn Beck @glennbeck]

.@jsolomonReports predicts that the SPLC case is only the beginning of what's to come from this DOJ:

“I think we’re about to enter into a period of MAAA. Make America Accountable Again. I think with Pam Bondi moved aside, the speed at which the Justice Department will move on things that have been working in the system for months is picking up.

I think in the summer and fall, we are going to talk a lot more about a case called "Operation Round River. Its goal was to neutralize anyone who would dare suggest there was a corrupt relationship between Joe Biden, Hunter Biden, and the Ukrainian Government or the Ukrainian company Burisma.

All the people I’ve talked to in government think that Round River may be the most JAW-DROPPING of the four codename investigations that targeted Donald Trump and his followers.”

[andrew @Andrewhlwx]

Wow 😱😱

[DataRepublican (small r) @DataRepublican]

🧵 THREAD: The true reason Pete Hegseth is being targeted is because he's standing between President Trump and a coup

@PeteHegseth named the institutions... CFR, Brookings, the general class... in 37 seconds in a video by @Liz_Wheeler . Within 72 hours of his nomination, a color revolution planning document cited him as an insider threat.

They didn't go after him because of drinking. They didn't go after him because of women. They went after him because every color revolution manual ever written says the same thing: you cannot topple a government unless the security forces defect. And a loyal Secretary of Defense is the one person who makes sure they don't.

I have the receipts. Their own documents. Their own training sessions. Their own words on camera.

As always, patience as I pull together the thread. 👇

[andrew @Andrewhlwx]

@MarioNawfal No irony here — it's a masterful case of tit-for-tat : using the opponent's own methods against them.

[andrew @Andrewhlwx]

sigh

[Brian Eastwood @BrianEastwoodx]

I will vote in the midterms.

But I’ll tell you this, the excitement is gone.

The GOP has failed miserably with the power they’ve been given.

Others won’t show up at all in the midterms, promises made, promises broken.

This isn’t about Trump. It’s about spineless leadership in Congress.

FFS…..

[Lara Logan @laralogan]

I cannot imagine that Pres Trump does not know that if he failed to hold those people accountable for the crimes of “treason & sedition”, this country is gone. And so is he & everyone/everything he loves. They will show no mercy, no regard for the law, no quarter given. It will be vindictive & irreversible this time & they will not stop until every person they believe is standing in their way is annihilated.

[andrew @Andrewhlwx]

@MargoMartin47 @realDonaldTrump @Cristiano

[Matt Gaetz @mattgaetz]

I love Trump, MTG, Massie, Tucker….and even those I feel are too accommodating to the worst decisions made by Israel’s government.

I won’t be baited into attacking friends and leaders in our movement because some people disagree on some things.

[andrew @Andrewhlwx]

@BoyDragen @RealJohnnyYu 一查就有啊 👇🏼
流行病学家���古拉斯·胡舍尔去年三月列出了抗新冠病毒mRNA注射剂可能致癌的10种方式。我们认为，根据100多项（并非全部）研究，这份清单（来自2023年12月发表在Cureus杂志上的一项研究[2]）现在可以扩展到17项。

https://t.co/AFMJq1CUz6

[James Hsieh @JamesHsiehtw]

3小時，16支Charlie Kirk短影片．翻譯上字完畢

從辯論，短講，鼓勵，到談人生

介紹查理給大家認識，那群瘋左就集體對我做抹黑攻擊

我就給大家更多，周末要瘋大家來瘋

還沒追蹤的快追

晚點上菜

[andrew @Andrewhlwx]

RIP Charlie 🙏🏼🙏🏼🙏🏼

[John Basham @JohnBasham]

A Radical Leftist Ended This Innocent Babies Father Today!

[Johnny Yu 強尼大哥 @RealJohnnyYu]

Ivermectin mechanisms against Covid
為什麼 伊維 防 新冠的 解釋

[andrew @Andrewhlwx]

@RealJohnnyYu 🤣🤣🤣

[Johnny Yu 強尼大哥 @RealJohnnyYu]

mRNA 基因治療癌症
在這邊只是轉述 這個技術
並不代表 個人 贊成這個技術

mRNA技术最初为COVID-19疫苗开发，现被应用于治疗癌症，通过利用人体免疫系统和细胞机制靶向并摧毁癌细胞。以下是其工作原理的简要说明，基于当前研究和应用：

### 1. **mRNA癌症疫苗**
- **机制**：mRNA疫苗编码生成特定癌症相关抗原的指令，这些抗原是癌细胞表面或特有的蛋白（如肿瘤特异性新抗原）。注射后，mRNA进入细胞，翻译成这些抗原。免疫系统将这些抗原识别为外来物，触发强烈的免疫反应，包括T细胞激活，攻击表达这些抗原的癌细胞。
- **个性化疫苗**：许多mRNA癌症疫苗针对个体肿瘤定制。通过肿瘤活检进行基因测序，识别独特突变（新抗原），然后设计编码这���特定靶点的定制mRNA疫苗。例如，Moderna和BioNTech正在为黑色素瘤、肺癌和胰腺癌等开发个性化疫苗。
- **示例**：
- **黑色素瘤**：BioNTech的BNT111与cemiplimab联合使用，在II期试验中对晚期黑色素瘤显示出良好效果，增强了针对肿瘤特异性抗原的免疫反应。
- **胰腺癌**：纪念斯隆凯特琳癌症中心与BioNTech合作的mRNA疫苗（autogene cevumeran）用于胰腺导管腺癌，试验显示一半患者产生免疫反应，部分患者无复发生存期延长。

### 2. **mRNA用于蛋白质替换或增强**
- **机制**：mRNA可编码治疗性蛋白，替换缺陷蛋白或增强抗癌活性。例如，mRNA可指导细胞产生细胞因子（如IL-2）以增强免疫反应，或产生直接靶向癌细胞的单克隆抗体。
- **应用**：Moderna的mRNA-4359在I/II期试验中编码免疫调节蛋白，增强实体瘤的T细胞活性。另一个例子是编码双特异性抗体的mRNA，连接癌细胞和免疫细胞，促进靶向杀伤。

### 3. **CAR-T细胞疗法增强**
- **机制**：mRNA可��时修改T细胞，使其表达识别癌细胞���记的嵌合抗原受体（CAR）。与传统CAR-T疗法通过病毒载体永久改变T细胞不同，mRNA-based CAR-T疗法引入临时CAR表达，降低细胞因子释放综合征等风险。
- **示例**：BioNTech的BNT211结合靶向claudin-6的mRNA-based CAR-T疗法与mRNA疫苗（CARVac），在I/II期试验中对睾丸癌和卵巢癌等实体瘤显示疗效。

### 4. **直接靶向肿瘤**
- **机制**：mRNA可编码诱导癌细胞凋亡或抑制肿瘤生长的蛋白。通过纳米颗粒传递，mRNA可靶向肿瘤部位，局部产生治疗性蛋白，减少系统性副作用。
- **示例**：编码肿瘤抑制蛋白或促凋亡分子的mRNA正在研究中，以直接破坏癌细胞存活。

### mRNA技术治疗癌症的主要优势
- **精准性**：个性化mRNA疫苗靶向独特肿瘤突变，减少脱靶效应。
- **速度**：一旦识别肿瘤突变，mRNA可快速设计和合成。
- **灵活性**：mRNA可编码多种蛋白，从抗原到抗体，支持多样化治��方法。
- **联合潜力**：mRNA疗法常与检查点抑制剂（如pembrolizumab）结合，增强���疫反应，如头颈部鳞状细胞癌试验所示。

### 挑战
- **传递**：mRNA需要脂质纳米颗粒到达靶细胞并避免降解，实体瘤血管分布差可能增加复杂性。
- **免疫抑制**：肿瘤常创造免疫抑制环境，可能限制mRNA疫苗疗效，除非与其他疗法结合。
- **持久性**：mRNA的短暂表达可能需要重复给药，不像传统CAR-T疗法的永久基因编辑。
- **成本与可扩展性**：个性化疫苗资源密集，但制造进步正在降低成本。

### 当前状态
- **临床试验**：超过25种mRNA-based癌症疗法正在进行临床试验，针对黑色素瘤、肺癌、胰腺癌和结直肠癌等。Moderna的mRNA-4157（与pembrolizumab联合）在IIb期试验中使黑色素瘤患者术后复发风险降低44%。
- **FDA认证**：多种mRNA疗法获得FDA快速通道或突破性疗法认证，表明可能加速批准。
- **商业前景**：专家预测mRNA癌症疫苗可能在1-2年内获批用于特定癌症，到2030年���广泛应用。

### 实际案例
对于胰腺癌，患者肿瘤活检后通过基因测序识别新抗原。合成编码这些新抗原的mRNA疫苗，通常肌内注射。患者细胞产生新抗原，促使T细胞识别并攻击癌细胞。2023年一项研究显示，16名患者中有8人产生免疫反应，部分患者无复发生存期延长。

[andrew @Andrewhlwx]

官宣: 美国卫生与公众服务部罗伯特·F·肯尼迪部长刚刚彻底摧毁了世界卫生组织和全球疫苗免疫联盟，称他们每年“给超过1亿黑人和棕色人种婴儿注射硫柳汞”！🚨

硫柳汞是剧毒——绝不应出现在疫苗中！Geier 等人的一项全面综述发现：

⚠️ 微量硫柳汞会破坏人体神经元，损伤线粒体，并削弱抗氧化防御系统。

⚠️ 人体研究显示，硫柳汞与胎儿死亡、出生缺陷、��闭症、多动症、抽动症和发育迟缓有关。

⚠️ 对脑细胞的毒性比铅或甲基汞更大。

这就是他们声称小剂量“安全”的含汞神经毒性防腐剂？

关于硫柳汞对人体影响的研究表明，即使浓度达到目前疫苗中施用的水平，微量硫柳汞也具有毒性，并可能造成诸多有害后果。

在世界卫生组织面临灾难性时刻之际，罗伯特·肯尼迪和特朗普政府刚刚彻底禁止所有疫苗中使用汞，并要求世界各地的监管机构也采取同样的措施来保护儿童。

这是一个巨大的转变，必将使整个被利益集团操控的“全球卫生事业”陷入危机。👏

https://t.co/pHnQ6TUGFb

[Nicolas Hulscher, MPH @NicHulscher]

Thimerosal Is EXTREMELY Poisonous — Should NEVER Have Been in Vaccines

A comprehensive review by Geier et al found:

⚠️ Tiny doses destroy human neurons, damage mitochondria, and cripple antioxidant defenses.

⚠️ Linked in human studies to fetal death, birth defects, autism, ADHD, tics, & developmental delays.

⚠️ More toxic to brain cells than lead or methylmercury.

[andrew @Andrewhlwx]

@RealJohnnyYu https://t.co/E12if02SXF

[Donald J. Trump @realDonaldTrump]

When I was 18, people called me Donald Trump. When he was 18, @BarackObama was Barry Soweto. Weird.

[andrew @Andrewhlwx]

@RealJohnnyYu 请教大鸽，像这样心脏骤停的猝死是不是可视为myocarditis?