RanBP2-dependent SUMOylation of G3BP2 inhibits formation, and promotes disassembly, of stress granules | Molecular Biology of the Cell https://t.co/7p6zc49KSY
PPN has updated its Influenza-Associated Encephalopathy or Encephalitis (IAE) and Acute Necrotizing Encephalopathy (ANE) resource to help guide patient care. Update includes information on case reporting, clinical characteristics of ANE, and more: https://t.co/erd93nHUY2
@cboyca@grok @Saraih33 @BGatesIsaPyscho 109 cases of influenza encephalopathy. 26 cases of ANE (US only).
ANE is not the only type of encephalopathy caused by influenza, but it is the most devastating. Influenza is not the only virus to cause ANE.
The worst form - acute necrotizing encephalopathy (ANE) - inflammatory and hemorrhagic destruction of deep brain structures.
Children with ANE had 44× higher odds of death or severe disability.
ANE isn’t a mild complication - it’s a neuroinflammatory catastrophe.
Běijīng, Zhōngguó
*By Day 28, acute necrotizing encephalopathy had killed 45.9% of our kids
*Among severe kids with ANE-SS ≥5, 65.7% died
*Death rates were 38.9% (2022), 36.8% (2023), but only 16.7% (2024)
*We could afford Actemra only for our severe kids
https://t.co/DkZPQmaa5C
15-year-old boy
4 days of fever → seizures → unconscious
CT scan: bilateral thalamic hypodensities.
Not your routine viral encephalitis.
This is where you must think of Acute Necrotizing Encephalopathy (ANE) — a para-infectious cytokine storm that needs early steroids & immunomodulation.
🧠 Recognize early. Act fast. Outcomes depend on it.
#NeuroTwitter #ANE #Encephalopathy #NeurocriticalCare
"Acute necrotizing encephalopathy" is a rare flu complication in kids, causing brain swelling and immune reactions.
This serves as a harsh reminder of the importance of the flu vaccine, as most of the affected kids had not received it. Read more here: https://t.co/P6YuTrgH71
Influenza-associated acute necrotizing encephalopathy (IA-ANE), is a rare and severe neurologic complication, that causes high morbidity and mortality that presents with encephalitis, fever, seizures, thrombocytopenia, elevated liver enzymes, and elevated protein in the cerebrospinal fluid (CSF), and requires prompt clinical assessment, intensive management and treatment, and prevention.
Influenza and acute necrotizing encephalopathy – the genetic dimension | Beyond the Ion Channel
...we just published our blog post on Acute Necrotizing Encephalopathy (ANE) and RANBP2 from the recent study in JAMA.
https://t.co/dk8KMZLxc5
WFN highlights the latest Neuroinfectious Disease Update [August '25], covering critical developments in influenza-associated encephalopathy (IAE) and acute necrotizing encephalopathy (ANE), H5N1-related encephalitis, and the recent Nipah virus outbreak in Kerala, India. The report emphasizes the importance of early recognition and research on these severe neurologic complications to strengthen global brain health.
Read more here 👉 https://t.co/lQ7k5yO7tU
Stanford Medicine researchers hope to raise awareness about a condition called influenza-associated acute necrotizing encephalopathy, to inform parents and physicians about its prevention and treatment. https://t.co/WGYoHAaTc7
⚡️ANE can strike without warning—in anyone, at any age.
Follow the link in our bio for the full story.
👨👩👧👧Together, we can raise awareness.
👨👩👦👦Together, we can save lives. #influenza#ANEawareness#AcuteNecrotizingEncephalopathy