Dr. Anne Schuckman @USC_Urology highlighted critical NMIBC questions:
❓ Are IO + BCG gains (+5–7%) enough given ↑toxicity?
❓ Does BCG-driven ↑PD-L1 support adding IO?
❓ Can IO meaningfully address the BCG shortage?
❓ Do benefits outweigh cost + risk?
#DAVAGU
Our review “ Circulating tumour DNA and circulating tumour cells in bladder cancer — from discovery to clinical implementation” is now out in @NatRevUrol
A tour de force by @SiaLindskrog and Trine Strandgaard - kudos 🏆and thanks to all co authors for your contributions 🙏 Catherine Alix-Panabières, @MattGalsky , @tompowles1 Mads Agerbæk, Jørgen Bjerggaard Jensen, Iver Nordentoft.
You can access the full text here: https://t.co/nIHCqiOjSF
In the review, we discuss:
*The biology and detection of ctDNA and CTCs in bladder cancer
* How liquid biopsy enables:
Early detection of recurrence
Monitoring of treatment response
Detection of minimal residual disease (MRD)
* Personalized adjuvant treatment guidance
* The pros and cons of tumour-informed vs. tumour-agnostic strategies
* Insights from pivotal clinical trials (TOMBOLA, IMvigor011, MODERN) and their potential impact
* The road to clinical implementation: technical, logistical, and regulatory considerations
* The combined value of ctDNA, utDNA, and CTCs in reshaping the bladder cancer care pathway
Why it matters:
Liquid biopsy is moving from promise to practice — with real potential to personalize and improve bladder cancer treatment.
https://t.co/2dLXL5dq8D
"Savage! Oh my God!!! 🙌 SEE YA!!! 🔥 What a game! Walk-off grand slam from Freddie Freeman electrifies a sold-out Dodger Stadium, sealing an improbable 6-3 victory over the Yankees! We love LA and we love it! LET’S GO DODGERS! 💙⚾️
A 10-year-old kid caught Freddie Freeman's walk-off grand slam in Game 1 of the World Series - his parents told him he was going to the orthodontist then they surprised him with Dodgers Stadium 🥺 🥺🥺 How can you not be romantic about baseball? https://t.co/CQQXaMv4z1
The 10-year-old kid who caught Freeman’s walk-off grand-slam ball didn’t know he was going to the game until he got to Dodgers Stadium. His parents told him he was going to the dentist. https://t.co/9czToaicgm
In a moment to remember, 10-year-old Zac from Venice scored the ultimate souvenir at Dodger Stadium – Freddie Freeman’s game-winning, walk-off grand slam ball from Game 1 of the World Series! #Dodgers#WorldSeries#FreddieFreeman#WalkOff
https://t.co/1KelJU6FPL
Improving access to trials across communities is critical: @ctleeuro's brilliant #GU24 keynote outlines the problem and some solutions
✅ Bring trials to pts, open at sites that care for diverse communities
✅Design trials inclusively with community input
✅Support pt navigation
🙏Thank you @ncidirec
and @NIHDirector for making this a national priority
So grateful to the AUA and the Spanish Association of urologists for the chance to present the Best of Bladder and Kidney in beautiful la coruna, spain!
Highlights of this week: assisting @AnneSchuckmanMD in creating a neobladder and @DrAsanad walking me through a radical orch. An amazing last two weeks back on my Uro Onc rotation with amazing seniors like Kian, Twitter-less Jeff Lin and Jullet Han, and of course @uro_nima
Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study - The Lancet Public Health https://t.co/LPz8dqVee5