The line came as an answer to a direct question: Chamath Palihapitiya, one of the All-In hosts, asked Vance near the end of the episode what message needed to be delivered before November, and the closing pitch was what came back.
Why endure decades of tooth decay, pain, sleepless nights, headaches, nauseated stomach, crying your eyes, out, etc., when you can just end all the suffering once and for all!