AntibioticPermeation

The Center for Antibiotic Discovery and Resistance discovers principles that govern antibiotic permeation into bacterial cells and develops new antibiotics.

[AntibioticPermeation @APermeation]

Our new study of P. aeruginosa drug permeability is now published: https://t.co/ytmSZGEOf9

[AntibioticPermeation @APermeation]

Recognition of quinolone antibiotics by the multidrug efflux transporter MexB of Pseudomonas aeruginosa - now published in Physical Chemistry Chemical Physics https://t.co/4Dvy2iDjCy

[AntibioticPermeation @APermeation]

Antibiotic accumulation optimization: Structure–Uptake Relationship Studies of Oxazolidinones in Gram-Negative ESKAPE Pathogens https://t.co/rVNUN5lnFS

[AntibioticPermeation @APermeation]

A review article from the Center focused on recent quantitative advances in drug efflux and permeation: https://t.co/BriUE7NqEk

[AntibioticPermeation @APermeation]

The Center just published the application of our technology to a designed library of oxazolidinones: Structure–Uptake Relationship Studies of Oxazolidinones in Gram-Negative ESKAPE Pathogens https://t.co/VTchXaXpcZ

[Helen Zgurskaya @MultidrugEfflux]

@APermeation

[Helen Zgurskaya @MultidrugEfflux]

@APermeation Analysis of Orthogonal Efflux and Permeation Properties of Compounds Leads to the Discovery of New Efflux Pump Inhi… https://t.co/2q7PYPE2IR

[AntibioticPermeation @APermeation]

Making sense of drug-efflux transporters in the physiological environm... https://t.co/yeYzu5GeAu

[AntibioticPermeation @APermeation]

We developed and validated a method to analyze compounds accumulation in difficult bacteria: Property space mapping of Pseudomonas aeruginosa permeability to small molecules https://t.co/7bAy3lYycF

[AntibioticPermeation @APermeation]

A new database for antibiotics - AB-DB: Force-Field parameters, MD trajectories, QM-based data, and Descriptors of Antimicrobials. Sci Data 9, 148 (2022). https://t.co/DteZjnruuw

[AntibioticPermeation @APermeation]

Vote for reviews in Issue 9, 2021!

[Chemical Reviews @ACSChemRev]

Vote for #YourFavoriteReview in Issue #17: https://t.co/mfFP8mGj3w

[Chemical Reviews @ACSChemRev]

Vote for #YourFavoriteReview in Issue #17: https://t.co/mfFP8mGj3w

[Expertscape: Your Source For Medical Experts @Daily_Experts]

During World Antimicrobial Awareness Week (Nov 18-24, 2021), we congratulate Dr. Helen I Zgurskaya of the University of Oklahoma -- Recognized as an Expertscape World Expert in Multiple Drug Resistance.
https://t.co/C4ZgJLEcd9

[AntibioticPermeation @APermeation]

Excited to contribute to a discovery of "A selective antibiotic for Lyme disease" https://t.co/lsUKzcs2dG

[AntibioticPermeation @APermeation]

Peptidoglycan is an additional player in the assembly of efflux pumps: Lpp positions peptidoglycan at the AcrA-TolC interface in the AcrAB-To... https://t.co/dG1hlUdhuv

[AntibioticPermeation @APermeation]

Mechanistic Duality of Bacterial Efflux Substrates and Inhibitors: Example of Simple Substituted Cinnamoyl and Naphthyl Amides https://t.co/nSyZ4ZyMzr

[AntibioticPermeation @APermeation]

Digging deeper into functions of efflux pumps: Loss of RND-type multidrug efflux pumps triggers iron starvation and lipid A modifications in Pseudomonas aeruginosa | Antimicrobial Agents and Chemotherapy https://t.co/2ojs68qvBJ

[AntibioticPermeation @APermeation]

The Thematic Issue on Transporters, Porins and Efflux Pumps is published: Chemical Reviews | Vol 121, No 9 https://t.co/tJsSZjGX7W

[AntibioticPermeation @APermeation]

Bacterial efflux transporters’ polyspecificity – a gift and a curse? https://t.co/1yLPiXELF7

[AntibioticPermeation @APermeation]

ACS Infectious Diseases Zoom Pop-Up featuring graduate students from the Nathaniel Martin lab (one of our EAB members) as speakers will take place on Monday, May 10, at 10 am EST. The link to the registration page is here: https://t.co/w63kfdLRN7