The Center for Antibiotic Discovery and Resistance discovers principles that govern antibiotic permeation into bacterial cells and develops new antibiotics.
Recognition of quinolone antibiotics by the multidrug efflux transporter MexB of Pseudomonas aeruginosa - now published in Physical Chemistry Chemical Physics https://t.co/4Dvy2iDjCy
The Center just published the application of our technology to a designed library of oxazolidinones: Structure–Uptake Relationship Studies of Oxazolidinones in Gram-Negative ESKAPE Pathogens https://t.co/VTchXaXpcZ
@APermeation Analysis of Orthogonal Efflux and Permeation Properties of Compounds Leads to the Discovery of New Efflux Pump Inhi… https://t.co/2q7PYPE2IR
We developed and validated a method to analyze compounds accumulation in difficult bacteria: Property space mapping of Pseudomonas aeruginosa permeability to small molecules https://t.co/7bAy3lYycF
A new database for antibiotics - AB-DB: Force-Field parameters, MD trajectories, QM-based data, and Descriptors of Antimicrobials. Sci Data 9, 148 (2022). https://t.co/DteZjnruuw
During World Antimicrobial Awareness Week (Nov 18-24, 2021), we congratulate Dr. Helen I Zgurskaya of the University of Oklahoma -- Recognized as an Expertscape World Expert in Multiple Drug Resistance.
https://t.co/C4ZgJLEcd9
Peptidoglycan is an additional player in the assembly of efflux pumps: Lpp positions peptidoglycan at the AcrA-TolC interface in the AcrAB-To... https://t.co/dG1hlUdhuv
Digging deeper into functions of efflux pumps: Loss of RND-type multidrug efflux pumps triggers iron starvation and lipid A modifications in Pseudomonas aeruginosa | Antimicrobial Agents and Chemotherapy https://t.co/2ojs68qvBJ
ACS Infectious Diseases Zoom Pop-Up featuring graduate students from the Nathaniel Martin lab (one of our EAB members) as speakers will take place on Monday, May 10, at 10 am EST. The link to the registration page is here: https://t.co/w63kfdLRN7