Arturo Bujarrabal Dueso

PhD Student in Schumacher Lab @CECAD_
Before, studied @UAM_Madrid

Future PI in aging research, contact now to collab in 20...28?

[Zane Koch @zanehkoch]

long-lived species and humans living 100+ years are known to have increased DNA repair capacity

but how DNA repair could be boosted to extend human lifespan is largely unknown

our research in Nature Aging today proposes a target to enable such a boost: the DREAM complex

[Björn Schumacher @schumacherbj]

@NaturePortfolio @ArBujarrabal @George_Garinis @CECAD_ @UKKoeln Bujarrabal-Dueso, A., Garinis, G.A., Robbins, P.D. et al. Targeting DNA damage in ageing: towards supercharging DNA repair. Nat Rev Drug Discov (2025). https://t.co/oDs5wYGXvo

[Björn Schumacher @schumacherbj]

Targeting DNA damage in ageing: towards supercharging DNA repair, read now our latest article in @NaturePortfolio Nature Reviews in Drug Discovery. @ArBujarrabal @George_Garinis Paul Robbins Jan Vijg @CECAD_ @UKKoeln
Free access to the article here:
https://t.co/T2rX40orEC

[Matthias Rieckher @OMathioso]

Excited to announce our paper in @NAR_Open: "Distinct #DNARepair mechanisms prevent #Formaldehyde toxicity during development, reproduction, and aging." https://t.co/RE3P7XPgSZ

[David Meyer @Meyer_DH]

Read our new paper about different neuronal aging rates! 🧠
And discover how we identified new compounds that might be key for neuroprotection.
🔬 🫐
#Neuroscience #Aging #Biotech (1/5)

[David Meyer @Meyer_DH]

It's finally out!
Read our updated story about stochasticity and #aging clocks.
We restructured the paper, reworked the text, and included more validation. 👇 #bioinformatics

[David Meyer @Meyer_DH]

We updated our preprint and validated the stochastic clock on ~17k new samples, showing that also a variety of mammalian species, age acceleration (smoking) and deceleration (e.g. calorie-restriction), as well as reprogramming are predictable with just one biological sample+noise

[Björn Schumacher @schumacherbj]

Congratulations to ⁦⁦@ArBujarrabal⁩ receiving the Stefan-Jentsch-Award at the 6th German-French DNA Repair meeting 2023 in Mainz by Julian Stingele of the German Society for DNA Repair. ⁦@imbmainz⁩⁩ ⁦@CECAD_⁩ ⁦@UKKoeln⁩ @FOR5504 ⁦@UniCologne⁩

[Arturo Bujarrabal Dueso @ArBujarrabal]

Today I presented my thesis work about the DREAM complex at the 6th German-French meeting in #DNArepair and received the DGDR Stefan Jentsch award!! 🎉 A huge honour and a great conference!!

[Björn Schumacher @schumacherbj]

Congratulations @SiyaoWang1005 on the new group leader positions @imbmainz Looking forward to your next breakthrough discoveries on epigenetic regulation of genome stability, inheritance and aging.

[Arturo Bujarrabal Dueso @ArBujarrabal]

@TheVilchezLab @Nature Very interesting, congratulations!

[VitaDAO 💛 @vitadao]

📢Announcing the 2nd batch of speakers for the 3rd VitaDAO DeSci & Longevity Symposium!

🗣️Speakers: @Vinz_Sorrentino, Aldo de Pape, @ArBujarrabal, @EmmaTeeling1, @manveerbasra_
Sign up now!👇
https://t.co/bExISgF4zy

[Arturo Bujarrabal Dueso @ArBujarrabal]

@CeronLab @schumacherbj Thank you very much! You are right with the issues of inhibiting DREAM, and although the lin-52 mutant we used is already better than other mutants of DREAM on this, finding a way of isolating DNA repair from the equation is a must! Hopefully we can follow it up :)

[Arturo Bujarrabal Dueso @ArBujarrabal]

It is officially out! It has been a long time. Check the paper on how the DREAM complex represses DNA repair, and limiting its function can keep the genome healthy and without damage!
👇

[Björn Schumacher @schumacherbj]

Our DREAM paper is out: We found the first master regulator of DNA repair capacities! Read and re-tweet now: The DREAM complex functions as conserved master regulator of somatic DNA repair capacities, @CECAD_ @UKKoeln @UniCologne
https://t.co/rVMe4rAxaf

[Arturo Bujarrabal Dueso @ArBujarrabal]

@TWBredy @OdedRechavi @schumacherbj Yes, in these non-replicative cells the repair they have is enough to extend beyond the reproductive lifespan and most healthspan. Having even better repair would probably just have been a waste of energy evolutionary speaking. Only now with current lifespans it is an issue.

[Arturo Bujarrabal Dueso @ArBujarrabal]

@PetrovADmitri @OdedRechavi @schumacherbj Yes to the developing! But do not take anything yet. DREAM complex members are involved in other complexes to be wary of and inhibiting DREAM could promote cell division by itself in some cells. More research needs to be done!

[Arturo Bujarrabal Dueso @ArBujarrabal]

@TWBredy @OdedRechavi @schumacherbj Good difficult question. 1st possibility, DNA repair mechanisms might have evolved to be co-regulated with germline+cell cycle genes, so, deregulation of repair genes might hamper differentiated somatic cell function.

[Arturo Bujarrabal Dueso @ArBujarrabal]

@AlexanderMWolf7 @schumacherbj @CECAD_ @UKKoeln @UniCologne Focusing only on DNA repair, as many somatic cells are replaceable it might be more energy and function efficient to replace a cell as it gets damaged rather than keeping it spending resources on its repair. Just a possibility

[Arturo Bujarrabal Dueso @ArBujarrabal]

@AlexanderMWolf7 @schumacherbj @CECAD_ @UKKoeln @UniCologne DREAM regulates other things part of the same package; DNA repair+cell division and germline related genes. The effects on somatic cells are good in terms of DNA repair but could be detrimental in other cases. Hopefully we can limit this effect to DNA repair even more, we'll see!

[Arturo Bujarrabal Dueso @ArBujarrabal]

@DavidBahry @schumacherbj We have not looked into this but literature shows that there might be a connection. In the end, DREAM, mTOR, GH, all can regulate initiation of cell cycle, something to dig into!