Thread au secours .
Lui c’est Rayen Fakhfakh il est étudiant en médecine, en 5e année. Tunisien il est arrivé en France à 12 ans, il est entré en médecine « je suis externe, je veux devenir médecin et servir ce pays »
Et il vient de recevoir une OQTF!
La préfecture, voix du gouvernement veut le foutre dehors! (1)
As requested by many, here is a post trying to explain the differences between Exercise-drived lactate and Cancer-derived lactate.
Exercise-Derived Lactate:
During high-intensity exercise, lactate is produced as skeletal muscles rely more heavily on glycolysis. However, lactate is eventually cleared and oxidized by mitochondria—both within active muscle fibers and in distant tissues like the heart, liver, and brain. This dynamic lactate shuttling fuels oxidative metabolism acting probably as the preferred fuel for cells. In addition to being a fuel, lactate functions as a signaling molecule and “exerkine”, activating beneficial pathways like PGC-1α, AMPK, and BDNF, which promote mitochondrial biogenesis, neuroplasticity, angiogenesis, and anti-inflammatory effects. Exercise-derived lactate communicates across organ systems to enhance metabolic flexibility, homeostasis and systemic health. Once exercise activity ceases, lactate is cleared by mitochondria in active muscle and the rest of the body.
Cancer-Derived Lactate: A key player in carcinogenesis
In contrast, cancer cells produce large amounts of lactate (Warburg effect), even in the presence of oxygen. Unlike during exercise, this lactate is not effectively cleared and although it is also used as a fuel, lactate accumulates chronically and as a signaling molecule, it elicits multiple deleterious effects key for carcinogenesis.
According to our “lactagenesis hypothesis” (https://t.co/yViJoMQniW), cancer-derived lactate functions as a central regulator of carcinogenesis. We and others have recently shown that lactate modulates cancer’s gene expression through transcriptional activation andepigenetic mechanisms like histone lactylation. Lactate promotes angiogenesis, immune escape, metastasis, and metabolic self-sufficiency, also responsible for the acidosis of tumor microenvironment which makes it a further niche for carcinogenesis.
A decreased mitochondrial function capacity (probably due to genetic mutations) along with increased glycolytic flux result in excessive lactate production which as we propose through our "lactagenesis hypothesis", is the purpose and the explanation of the Warburg Effect.
I suggest you watch the videos of aid packages being dropped into the sea in Gaza.
Hungry men, women and kids swim out to bring them in.
Bombs and munitions are fired, killing some of them.
NO amount of “tHeY aRe TrYiNg To DeFeAt HaMaS” cope works here.
Disgusting.
JO de Paris 2024: "On aurait pu en profiter pour faire des Jeux à la Française" en limitant "le nombre de spectateurs qui viennent en avion", explique Jean-Marc Jancovici
"How much training will it take me to reach xyz performance?"
is a wasted question to ask your genie. You ask it every year and get no closer to the answer.
Better questions...
1/ "What limited me from training more consistently this year? Injuries? Life interruptions? Races? Travel?"
2/ "Was I getting a good fitness return on the training I was doing? Was the training making me better?"
3/ "What changes can I make in my day to day schedule and yearly calendar to improve on the above?"
Assurément le joueur le plus gentil avec qui j’ai eu le plaisir et la chance de travailler. Quelle tristesse!!
Courage à la famille. Merci pour ta joie et ton énergie.
#sadday
Ancien international avec les A, champion d'Europe U16 et U18, Ludovic Vaty est décédé à l'âge de 34 ans. L'Équipe de France partage la douleur de sa famille et ses proches.
🇫🇷 FLASH | #Farès, 29 ans et père de famille d’un petit garçon d’un an, est entre la vie et la mort après avoir secouru une dame âgée dans un immeuble qui prenait feu suites aux #émeutes.
👉 Les faits se sont déroulés dans la nuit du 28 au 29 juin dernier dans le 6ᵉ arrondissement de #Lyon.
Toutes nos pensées vont à sa famille. 🧡
On nous dit qu’il n’y a plus assez d’eau pourtant on lésine pas sur les lavages de cerveau.
Ca doit etre des lavages à sec, comme la sodomie.
#politics#climatchange#hoax
Nouveau Kollok à Strasbourg : tout sur la syndesmose -
Une soirée sur le thème de l'échange entre vous, notre expert et un chirurgienhttps://mailchi.mp/da5f636de120/calendrier-de-formations-12633994
✍🏻 Comme je le craignais, la Commission autorise la mise sur le marché d'insectes sans avoir étudié leur allergénicité et indique qu'aucune image ne sera apposée sur les produits !
Retrouvez ma question écrite à la Commission européenne et sa réponse.
➡️ https://t.co/yiJNhdZm77
Nestlé Waters privatise l'eau des sous-sols, ici cet éleveur Vosgien a interdiction de puiser l'eau de son terrain pour abreuver ses bêtes, les puits ont été condamnés.
Extrait de pièce à conviction avril 2020. France 3.