Bare

Hey there, I’m Bare/kinda YouTuber/16/obsess over bands with dead vocalists/politics suck/scream inside(not only)about tech bloggers and sometimes on cam/pascal

[Bare @BareGamer]

If you (re)post sexual content and follow me thinking I will be another free advertisement for you-then get fucked, you are blocked. You'll get blocked even if you aren't really advertising because I have no way of knowing your intentions, so sorry if you legit wanted to follow

[Otto Hans Wolf (Infantryman: Days Gone 🪖🐺🇺🇦) @OttoHansWolf]

Волинська різанина очима Навроцького та його підлабузників: 1943 рік, Бандера сидить в німецькому готелі "Заксенгаузен" на Лазурному узбережжі Ніци.Бандері скучно і він думає чим би розважитися.І тут йому дзвонить Ерік Кох та каже: "А чому би тобі не порізати поляків на Волині?"

[ᗺɹɐʞ Sóʍ, 𝚝𝚑𝚎 ᵣ𝚞𝚜𝚜𝚘𝚖ï𝚜ï𝚌 𝚙𝚘𝚕𝚎𝚌𝚊𝚝. @exileoftza]

jako Polka, pozwolę sobie nadmienić, że w sytuacji, kiedy mamy największą wojnę w Europie od czasu drugiej wojny światowej - również zaczętej przez ᵣuskich, stoimy u progu zbrojnej konfrontacji z ᵣuskimi, kiedy Stany Zjednoczone przejęli faszyści, kiedy ważą się losy Europy i świata, kiedy Ukraina to jedyne co oddziela polskie dzieci od masowych grobów i daje wam, pachoły, czas przygotować się na wojnę, potencjalnie światową - chwilowo pierdolę Wołyń i każdą inną historyczną zaszłość. mam wyjebane. mam głęboko w dupie kto ma rację i kto kogo mordował i dlaczego 100 lat temu. z resztą pierwsza odpowiedź Polaka na to pytanie brzmi zawsze i bezwzględnie: ᵣuscy.

wyście wszyscy doszczętnie ochujeli. dajcie się ᵣuskim szczuć na naród, któremu zawdzięczacie 5 lat odroczenia wojny na terytorium Polski. siedzicie na dupach i wydaje wam się, że jesteście bezpieczni - nie jesteście. ᵣuscy przetestowali naszą obronę przeciwpowietrzną dronami we wrześniu w zeszłym roku. orzesznik który uderzył we Lwowie potrzebowałby dodatkowe 1.5 minuty żeby przyjebać w centrum Warszawy.

ogarnijcie się, pojeby.

[Stop Killing Games Official @StopKilingGames]

Digital ownership is the only way to truly own your games, it aint that hard. @DoesItPlay1 is part of the movement for exactly that (and cause we like our discs).
Love or hate @Asmongold, but he’s completely right here: you can lose access to your game even if it’s on disc.

[Prism @fwprism]

Asmongold defends himself after facing backlash for his opinion on Sony's PlayStation decision to move away from physical media 👀😳

“People are getting a false sense of security about owning the piece of plastic, as if that actually gives them any privilege. You can still be software locked. Please do not miss the forest from the trees. The holy grail is consumer protections laws and regulations. Please stop thinking that because you own a disc, you have any sort of immutable right over the copyrighted content that you own. You can dog on me and shit on me and try to discredit me with everything else, but please do not lose sight of the end goal, which is better consumer protections, because nothing else will solve this problem”

[tern @1goodtern]

Russia: threatens to do something bad, does something bad, films itself doing something bad, then is accused of doing something bad.

Russian stooges: Why are you people so obsessed with Russia?

[tern @1goodtern]

Ok.
I've read "The Painful Truth About Long Covid" six times through, and I'm ready.

Here are ten clues in the article that point to the writer's bad faith.

[Harry Spoelstra @HarrySpoelstra]

Long COVID as a network disorder: a mechanism-anchored framework for biological stratification and therapeutic targeting

🚨Interesting new paper that strongly reinforces my own view on LC.

Long COVID is a syndrome, not a single disease, driven by a vicious network of broken systems post SarsCoV2. We’ve been treating too many “shadows” instead of the actual mechanisms.

➡️The paper’s core thesis:
- Long COVID is not one uniform disease but a heterogeneous “network disorder” (= syndrome) where interacting physiological systems create self-reinforcing loops.
- Symptom overlap masks completely different upstream mechanisms, which is why grouping patients only by complaints dilutes trial results.
- That’s why so many trials fail.
- Long COVID is a network disorder built on 6 measurable biological domains (often called endotypes/phenotypes) that constantly interact and amplify each other.

➡️Primary Domains/Phenotypes (objectively measurable, targetable nodes capable of generating multisystem symptoms):
1. Autonomic dysfunction (e.g, tilt-table, HRV)
2. Mitochondrial/bioenergetic impairment (e.g, CPET, lactate)
3. Endothelial/microvascular dysfunction
4. Gut dysbiosis/barrier disruption
5. Mast cell activation (e.g, tryptase, mediators)
6. Neuroendocrine dysregulation (e.g, cortisol, thyroid, sex hormones).

➡️Secondary Amplifiers (sustaining loops):
Persistent immune activation, viral antigen persistence (no replication?), autoantibodies, neuroinflammation, sleep destabilization.

➡️Framework Innovation:
- Presents Long COVID as a “network disorder” of interconnected physiological nodes linked by self-reinforcing feedback loops.
- Includes practical tables that list:
• domain-specific objective tests,
• typical symptom triggers,
• cross-node interactions, and
• explicit, falsifiable hypotheses (e.g, patients selected for autonomic dysfunction will respond significantly better to targeted therapy than patients matched only by identical symptoms).

➡️The practical tools:
• Clear tables of objective tests, triggers & cross-interactions
• Explicit falsifiable predictions (e.g, autonomic patients will respond to targeted Rx while symptom-matched controls won’t)
• A ready-to-use prototype screening tool for real stratification

➡️Author calls for:
Prospective validation comparing biologically enriched vs. symptom-only cohorts to test whether mechanism-guided selection sharpens therapeutic signals and clarifies pathophysiology.

‼️So, Symptom-based medicine has hit its ceiling in Long COVID. Not NEW!

Until patients are stratified and treated according to their dominant biological driver/phenotype, rather than their overlapping complaints, most clinical trials will keep failing and millions will stay untreated.

The network model is deliberately falsifiable as the author states: "Enriched cohorts must now deliver superior outcomes, or the field must finally admit it is still chasing “shadows” instead of mechanisms!"

The field has known for years that we’re dealing with a messy interconnected network. This paper didn’t discover that, it just handed us a clear clinical roadmap to stop pretending it’s one disease.

LC It’s ONE syndrome with 6 major driving mechanisms(phenotypes).

It’s evolutionary, not revolutionary… but exactly the kind of evolution the field desperately needs right now.

One may want to discuss/criticize this framework proposal, no problem, but let it be already very clear, LC is NOT ONE DISEASE, it’s a SYNDROME for which I thank the author!
https://t.co/tentkAbfW2

[Give A Shit About Nature @giveashitnature]

Farmers have figured out that the cheapest pesticide is a strip of flowers.

When you plant wildflowers through a crop field, not just around the edge but in strips running through the middle, you get ladybugs, lacewings, hoverflies, and parasitic wasps living in the field instead of visiting it.

They eat the aphids, the caterpillars, and the mites for free, all summer long.

In controlled trials, fields with tailored flower strips had leaf-beetle numbers 40 to 50% lower and crop damage cut by around 60%, enough to drop below the threshold where spraying was even considered worth it.

The flowers attract a standing army to our fields.

We spent decades engineering chemicals to kill the insects eating the crop, when the insects that eat those insects would have worked for the price of seed.

[Bare @BareGamer]

@SebAaltonen This is so weird though, why did they turn off those features on another console with nearly identical hardware?

[Rimantas ‡ @DarRamesnis]

@MAGAVoice I dont think you did.

[USERGORE @usergore_]

commission

[Linyvka 🇺🇦 @Linyvets_chan]

Пробую повернутись до постингу в ТВі, бо я надто лінива срака виявилась 💅. Тому буду рада репостам 👉👈🙂‍↕️

Малювалось від нудьги

#арткозацтво
#УкрАртПідтримка
#украрт

[Doodly @doodly_sheery]

brazilian miku

[XWine1 @XWineOne]

Since it's April 2nd now, time to clarify some things, this is real but it won't release for *obvious* reasons, but yeah we really did port XWine1 to Xbox One dev mode, oh and while we are at it, here's another real thing

[ҐРУНТ @grntmedia]

Угорщина десятки разів намагалася втручатися у внутрішні справи України, заявив Зеленський в інтервʼю Válasz Online.

Тред⬇️

[Half-Life Alyx NoVR @HL_Alyx_NoVR]

Check out never before seen footage of Half-Life 2 Episode 3!

Looks like you would be able to make ice bridges to scale walls and more!

[Right Wing Cope @RightWingCope]

elon fans are the dumbest people alive

[Michael | AnimatedGalaxy @BeforeThatCold]

@endermanch Windows