Benji Woolf

Perplexed sceptic & genetic epidemiologist @mrc_ieu @MRC_BSU @BristolUniPsych. Tutor @LSHTM & @StEdmundsCam.

[Stephen Burgess @stevesphd]

New pre-print "Mendelian randomization in a multi-ancestry world: reflections and practical advice" led by @amymariemason - https://t.co/DGW2DdmFym

[Mark Toshner @mark_toshner]

@stevesphd @BarWoolf @ERSpublications Really important work (and delighted to help) using pulmonary hypertension as a disease exemplar. Applicable across all rare disease I expect.

[Stephen Burgess @stevesphd]

New manuscript led by @BarWoolf "A cautionary note on the naive use of general-population biobanks to study pulmonary arterial hypertension" is now published at Euro Respiratory Journal @ERSpublications: https://t.co/f67T79vQ5N. Summary follows:

[Benji Woolf @BarWoolf]

One of my students @StEdmundsCam has a really remarkable story of overcoming adversity to study @Cambridge_Uni. Sadly his scholarship can't fund the rest of his degree so he is trying crowdfunding. Any help would be really appreciated, thank you very much! https://t.co/B3irpVstL3

[Stephen Burgess @stevesphd]

New pre-print online: "Context-stratified Mendelian randomization: exploiting regional exposure variation to explore causal effect heterogeneity and non-linearity", https://t.co/1QssGzqrsB. We propose an alternative approach to assess non-linearity in Mendelian randomization.

[Stephen Burgess @stevesphd]

@BarWoolf Forgot to add the link to the manuscript: https://t.co/MFxr7jVhAK.

[Stephen Burgess @stevesphd]

New paper published at AJE Advances: "The role of estimation in Mendelian randomization: should Mendelian randomization investigations provide estimates?" led by @BarWoolf and myself. Brief thread:

[Benji Woolf @BarWoolf]

Posting a tad late, but @jamesyrmsk and @dpsg108 and I have a new research letter in @intjepidemiol where we use negative controls to illustrate why drug use phenotypes should not be used as exposures in MR studies https://t.co/yIOJ8Ce9ya

[Danielle Newby @Danielle_Newby]

🚨 New preprint awaiting feedback! 🚨 led by the lovely and talented @martaalcalde18 looking at the relationship between PDE5 inhibition and Alzheimer's disease using #mendelianrandomization (spolier: we found nada) https://t.co/jd1XETKNzw

[Benji Woolf @BarWoolf]

And the accepted m/s is now out in the AJE! https://t.co/fEGFHmzfW8 Thank you to @htcronje @dpsg108 @stevesphd @LoukasZagkos @LarssonSC Summary can be found https://t.co/9gVqpPkX1d

[Benji Woolf @BarWoolf]

Had a lot of fun presenting our work (accepted this week at the AJE) on exposure miss-identification in MR, and how it results in directionally incorrect conclusions for studies of caffeine consumption at #mrconf24.

[Benji Woolf @BarWoolf]

Had a lot of fun presenting our work (accepted this week at the AJE) on exposure miss-identification in MR, and how it results in directionally incorrect conclusions for studies of caffeine consumption at #mrconf24.

[Benji Woolf @BarWoolf]

https://t.co/mqszCT3rqY really enjoyed watching this seminar by @HarvardEpi on measurement error. Lots of food for thought.

[Benji Woolf @BarWoolf]

@gushamilton Thank you Gus :)

[Benji Woolf @BarWoolf]

Our new study https://t.co/28nuS6EJy9 with James Perry, Charles Hong @mark_toshner, @stevesphd, @dpsg108, Martin Wilkins, and Chris Rhodes failed to find evidence supporting the use of IL6R inhibitors on pulmonary arterial hypertension.

[BMC Medicine @BMCMedicine]

New Mendelian Randomization from @LoukasZagkos @htcronje @BarWoolf @stevesphd @Yuan_AS @LarssonSC @jotzou @dpsg108 et al.: Long-term increases in circulating #caffeine may reduce bodyweight and the risk of osteoarthrosis and osteoarthritis. https://t.co/cPM49r3u6A

[Molecular Epidemiology Group UK (MEG-UK) @megukepi]

**Flash Talks Event** Benjamin Woolf @BarWoolf shares his research "Comparison of caffeine consumption behavior with plasma caffeine levels as exposure measures in drug-target Mendelian randomization studies" Vote for your favourite talk: https://t.co/SOqVzKV9Ww

[Stephen Burgess @stevesphd]

New paper: "A frequentist test of proportional colocalization after selecting relevant genetic variants": https://t.co/v8EgM37Ouq led by Ash Patel. We introduce a new test for colocalization in a frequentist paradigm. Thread follows!

[Benji Woolf @BarWoolf]

@stevesphd Is the latter 'prop-coloc-cond' meant to be 'prop-coloc-full' or should I have gone to bed a few hours ago?

[Benji Woolf @BarWoolf]

Really nice review by @htcronje and @stevesphd on the importance of sensible variant selection in MR

[Stephen Burgess @stevesphd]

Our review "Incorporating biological and clinical insights into variant choice for Mendelian randomisation: examples and principles" written together with @htcronje and published at @eGastro_BMJ is now available at https://t.co/b6i9wnJgBJ. Brief thread:

[Benji Woolf @BarWoolf]

@AlexTISYoung @stevesphd Interesting. My expectation would be that PDE5 inhib. has some other negative consequences e.g. (not sure if any one else has written about this or if it is only me) I've found it much harder to stay warm since being prescribed them. Betas size is due to scaling to a large dose